2021
DOI: 10.3390/pathogens10101303
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Abstract: Over the last years, invasive infections caused by filamentous fungi have constituted a serious threat to public health worldwide. Aspergillus, Coccidioides, Mucorales (the most common filamentous fungi), and Candida auris (non-filamentous fungus) can cause infections in humans. They are able to cause critical life-threatening illnesses in immunosuppressed individuals, patients with HIV/AIDS, uncontrolled diabetes, hematological diseases, transplantation, and chemotherapy. In this review, we describe the avail… Show more

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Cited by 26 publications
(9 citation statements)
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“…Other formulations could be developed in the future using delivery systems, such as nanoparticles, in order to improve the antifungal effect of the antimicrobial peptides herein studied. Peptides immobilized in nanoparticles are a promising option in fungal infections' control since this could potentiate the effect of some conventional antimicrobial or antifungal molecules and present a synergistic or additive effect in the infection control [32,33]. It would be interesting to address, in subsequent studies, the possible synergistic or additive effects that the mentioned peptides may present if together they deliver antifungal drugs currently used in clinics.…”
Section: Discussionmentioning
confidence: 99%
“…Other formulations could be developed in the future using delivery systems, such as nanoparticles, in order to improve the antifungal effect of the antimicrobial peptides herein studied. Peptides immobilized in nanoparticles are a promising option in fungal infections' control since this could potentiate the effect of some conventional antimicrobial or antifungal molecules and present a synergistic or additive effect in the infection control [32,33]. It would be interesting to address, in subsequent studies, the possible synergistic or additive effects that the mentioned peptides may present if together they deliver antifungal drugs currently used in clinics.…”
Section: Discussionmentioning
confidence: 99%
“…Inclusion criteria: (1) bronchial asthma; (2) elevated IgE levels against Aspergillus fumigatus; (3) elevated total IgE levels (>1000 IU/mL); (4) total eosinophil count >500 cells/ μ L in steroid naïve patients (may be historical); (5) the chest radiographic features consistent with ABPA may be transient (i.e., consolidation, nodules, tram-track opacities, toothpaste/finger-in-glove opacities, and fleeting opacities) or permanent (i.e., parallel line and ring shadows, bronchiectasis, and pleuropulmonary fibrosis). If the patient has symptoms and signs of type I and III allergy and infection of bronchus and lungs by Aspergillus, and Aspergillus hyphae are found on the smear of deep bronchial secretion or Aspergillus grows for many times, it can be diagnosed as ABPA [ 15 ]. Exclusion criteria: (1) the patient already has severe pulmonary dysfunction and (2) possible lung malignancies.…”
Section: Methodsmentioning
confidence: 99%
“…Reports have also suggested the role of other delivery systems displaying antifungal activity, for instance magnetic nanoparticles (MNPs), carbon nanotubes, and silica NPs ( Voltan et al, 2016 ). As per latest research, silver nanoparticles (AgNPs), due to the presence of β-cyclodextrin ( George et al, 2011 ); Zirconium oxide nanoparticles (ZrO 2 NPs; León-Buitimea et al, 2021 ), and nano-emulsion NB-201, due to presence of benzalkonium chloride (BZK; Brunet and Rammaert, 2020 ; Kajfasz et al, 2020 ), exhibit antifungal properties with higher toxicity against Mucorales and relatively low toxicity in human cells. Detailed mechanism of incorporation of drugs in nanoparticles is provided in Figure 6 .…”
Section: Role Of Nanomedicinementioning
confidence: 99%