Nanohybrids of Dendrimers and Carbon Nanotubes: A Benefaction or Forfeit in Drug Delivery?

Abstract

Introduction: Nanomaterials are emerging as a fascinating delivery systems being explored for the delivery of different bioactives including drug, diagnostic agents and genetic materials etc. Among these nanomaterials dendrimers and Carbon Nanotubes (CNTs) are being investigated for various biomedical applications. Although both of these nanomaterials have shown great potential in drug delivery yet their promising clinical applications are still suspected due to problems like toxicity, dispersibility etc. Scientists have been investigating the potential of nanohybrids comprising of dendrimers and nanotubes for biomedical applications. Few reports are also available on the toxicological profile of CNTs and dendrimers nanohybrids. Conclusion: The results of these investigations suggest two possibilities, first, hybrids of CNTs and dendrimers could suppress each other’s demerits while synergizing the potentials; second, prospective toxicity of nanohybrids on which different reports have discrimination in results. Future biomedical applications of CNTs-dendrimers nanohybrids require a thorough investigation on their toxicity and biological interactions.

3D-printed nanomedicines for cancer therapy

“…Nanomedicine, involving the integration of nanotechnology in multiple medical domains like medication repurposing, theranostic instruments, and site-specific drug delivery, prompts researchers to explore innovative approaches like multimodal targeting, stimuli-responsive release and theranostic applications. This exploration involves combining nanomaterials to create hybrid materials [ 7 , 8 ]. Additionally, nanomedicines hold enormous potential for a variety of theranostic applications in infectious diseases.…”

3D Printing in Development of Nanomedicines

“…Nanomaterials are also being used in combination as a hybrid to explore new possibilities such as dual targeting, stimuli responsive release, and theranostic applications. [ 11 , 12 ]. Nanomedicines are a promising tool for various theranostic application in infectious diseases, noncommunicable fatal diseases such as brain tumors, multidrug resistance (MDR) tumors, infectious diseases, metastatic tumors and relapsed tumors that are highly challengeable for clinical studies, crossing of therapeutic agents to brain (BBB), dodging the MDR pathways, inhibiting migratory tumor cells, immunostimulation, antiangiogenic activity, and removal of the cancer stem cells.…”

Nanotechnology in Wastewater Management: A New Paradigm Towards Wastewater Treatment

“…Nanotechnology is basically a manipulation of matter at the molecular and atomic levels to craft a new structure, device and system with superior electronic, optical, magnetic, conductive and mechanical properties [ 11 , 12 , 13 , 14 , 15 ]. Nanotechnology is being explored as a promising technology, and has demonstrated remarkable accomplishments in various fields including wastewater treatment.…”