2021
DOI: 10.3389/fnins.2021.652608
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Abstract: Light-activated biointerfaces provide a non-genetic route for effective control of neural activity. InP quantum dots (QDs) have a high potential for such biomedical applications due to their uniquely tunable electronic properties, photostability, toxic-heavy-metal-free content, heterostructuring, and solution-processing ability. However, the effect of QD nanostructure and biointerface architecture on the photoelectrical cellular interfacing remained unexplored. Here, we unravel the control of the photoelectric… Show more

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Cited by 14 publications
(20 citation statements)
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“…Working electrode was connected to the ITO back electrode, while the counter and reference electrodes were floating in the ionic aCSF medium. [ 24 ] The intensity‐dependent photocurrent and photovoltage measurements in Figure 3b,c showed the maximum achievable current density of 6 mA cm –2 and 290 mV photovoltage for RuO 2 BI under 445 nm 85 mW cm –2 LED illumination, respectively. Integrating the area under the photocurrent–time traces corresponds to the injected charges for each illumination intensity (Figure 3d) and RuO 2 BI has a charge injection density of more than 10 µC cm –2 for intensities greater than 30 mW cm –2 .…”
Section: Resultsmentioning
confidence: 99%
“…Working electrode was connected to the ITO back electrode, while the counter and reference electrodes were floating in the ionic aCSF medium. [ 24 ] The intensity‐dependent photocurrent and photovoltage measurements in Figure 3b,c showed the maximum achievable current density of 6 mA cm –2 and 290 mV photovoltage for RuO 2 BI under 445 nm 85 mW cm –2 LED illumination, respectively. Integrating the area under the photocurrent–time traces corresponds to the injected charges for each illumination intensity (Figure 3d) and RuO 2 BI has a charge injection density of more than 10 µC cm –2 for intensities greater than 30 mW cm –2 .…”
Section: Resultsmentioning
confidence: 99%
“…Primary Hippocampal Neuron Isolation and Culture: Primary hippocampal neuron isolation and culture protocol made as described in previous studies. [24,71] In brief, pregnant rat between embryonic day 15 and day 17 euthanized and hippocampal regions of embryos extracted. The hippocampi of embryos trypsinized in 0.25% Trypsin-EDTA solution (Thermo Fisher Scientific, MA, USA) with 2% DNase-I supplement (Ne-oFroxx, Einhausen, Germany), triturated, and centrifuged for dissociation of the neural tissue.…”
Section: Methodsmentioning
confidence: 99%
“…Immunofluorescence Staining and Imaging: Immunofluorescence staining and imaging protocols made in a similar way of a previous article. [71] In short, primary hippocampal neurons (2 × 10 5 cells per sample) and primary cardiac myocytes (1 × 10 5 cells per sample) cultured as explained above and incubated for 24 h on ITO substrates and the biointerfaces at 37 °C in cell culture incubator. Then, samples fixated at same day (Day 0) or maintained in appropriate cell culture conditions for two weeks (Day 14).…”
Section: Methodsmentioning
confidence: 99%
“…Procedures were carried out by responsible veterinarian and certified researchers for animal experiments. Primary hippocampal neuron isolation and culture protocols were performed according to our previous studies. , Hippocampus of E15-E17 Wistar Albino rat embryos were isolated and placed immediately in ice-cold Hank’s Balanced Salt Solution (HBSS, Thermo Fisher Scientific, MA, USA). Enzymatic digestion of the hippocampus was performed with incubation in %0.25 Trypsin-EDTA solution (Thermo Fisher Scientific, MA, USA) with 2% DNase-I supplement (NeoFroxx, Einhausen, Germany) for 20 min in a 37 °C incubator.…”
Section: Methodsmentioning
confidence: 99%
“…In addition, they have high optical stability with minimal photobleaching or chemical degradation . So far, core or core/shell structures of different QDs like mercury telluride (HgTe), cadmium selenide (CdSe), indium phosphide (InP), and aluminum antimonide (AlSb) were successfully used in photovoltaic biointerface architectures for photostimulation of neurons, but their operation was limited within the visible range. Alternatively, lead sulfide (PbS), which has a Bohr exciton radius of 18 nm and bulk bandgap of 0.41 eV, enables sensitive tuning of the absorption edge within the NIR spectral range …”
Section: Introductionmentioning
confidence: 99%