Nanoemulsions improve the efficacy of turmeric in palmitate- and high fat diet-induced cellular and animal models

Lee, Eun Ji; Hwang, Jae Joon; Kang, Eun Sil; Lee, Su Bi; Hur, Joon; Lee, Won Jin; Choi, Mi-Young; Kim, Jun Tae; Seo, Han Geuk

doi:10.1016/j.biopha.2018.11.006

Cited by 12 publications

(13 citation statements)

References 36 publications

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“…TE-NE treatment reduced the palmitate-induced lipid vacuole accumulation and ROS production, compared to curcumin treatment alone. In addition, SREBP-1, PPAR-γ2, cleaved caspase-3 and PARP levels were reduced with TE-NE treatment [95]. These data suggest that the use of nanoemulsions can improve curcumin's efficacy and results in significantly greater reduced cellular damage induced by palmitate ( Table 2).…”

Section: Effects Of Curcumin: In Vitro Hepatocyte Studiesmentioning

confidence: 78%

“…In a study by Lee et al (2019), treatment of HepG2 cells with curcumin loaded nanoemulsion (TE-NE; 10 µM) for 24 h resulted in significantly reduced palmitate-induced lipotoxicity [95]. TE-NE treatment reduced the palmitate-induced lipid vacuole accumulation and ROS production, compared to curcumin treatment alone.…”

Section: Effects Of Curcumin: In Vitro Hepatocyte Studiesmentioning

confidence: 99%

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Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies

2020

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Type 2 diabetes mellitus (T2DM) is a growing metabolic disease characterized by insulin resistance and hyperglycemia. Current preventative and treatment strategies for T2DM and insulin resistance lack in efficacy resulting in the need for new approaches to prevent and manage/treat the disease better. In recent years, epidemiological studies have suggested that diets rich in fruits and vegetables have beneficial health effects including protection against insulin resistance and T2DM. Curcumin, a polyphenol found in turmeric, and curcuminoids have been reported to have antioxidant, anti-inflammatory, hepatoprotective, nephroprotective, neuroprotective, immunomodulatory and antidiabetic properties. The current review (I of II) summarizes the existing in vitro studies examining the antidiabetic effects of curcumin, while a second (II of II) review summarizes evidence from existing in vivo animal studies and clinical trials focusing on curcumin’s antidiabetic properties.

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Section: Effects Of Curcumin: In Vitro Hepatocyte Studiesmentioning

confidence: 78%

Section: Effects Of Curcumin: In Vitro Hepatocyte Studiesmentioning

confidence: 99%

Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies

2020

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“…HepG2 cells obtained from the Korean Cell Line Bank (Seoul, Korea) were used in the present study. The cells were routinely maintained and cultured according to a previously described method (Lee et al, ).…”

Section: Methodsmentioning

confidence: 99%

Comparative effects of nanoemulsions loaded with duck oil and lard oil on palmitate‐induced lipotoxicity

Kang

Hur

et al. 2019

J Food Biochem

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The effects of duck oil and lard oil on lipotoxicity induced by saturated long‐chain fatty acids were evaluated in HepG2 cells. Lipotoxicity triggered by palmitate, a saturated fatty acid, was inhibited more by duck oil‐loaded nanoemulsion (DO‐NE) than by lard oil‐loaded nanoemulsion (LO‐NE) and control nanoemulsion (NE) in HepG2 cells. Accumulation of reactive oxygen species and lipid vacuoles in HepG2 cells induced by palmitate treatment was inhibited by DO‐NE but not by LO‐NE. Consistently, treatment of HepG2 cells with DO‐NE, but not with NE or LO‐NE, significantly reduced the expression levels of peroxisome proliferator‐activated receptor‐γ2 and sterol regulatory element‐binding protein‐1, which are key regulatory proteins in hepatic lipid accumulation. In addition, the cleavage of poly (ADP‐ribose) polymerase and caspase‐3 were reduced more by DO‐NE than by LO‐NE, indicating that DO‐NE directly attenuates cellular damage induced by palmitate. Collectively, these results imply that the biological activity of duck oil against palmitate‐induced cellular damage is more potent than that of lard oil. Practical applications Accumulated lipids in nonadipose tissues, especially the liver, cause lipotoxicity, a pathologic feature of hepatic disorders, by inducing oxidative stress. A nanoemulsion loaded with duck oil, which is a functional food widely consumed by Korean people, inhibited lipotoxicity by suppressing lipid accumulation in HepG2 cells exposed to palmitate, which mimic nonalcoholic fatty liver disease. Thus, we propose that duck oil can be used as a functional food to improve lipid‐induced hepatic disorders.

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“…Diterpenoids also showed lipase inhibitory effects as they inhibited the activity of pancreatic lipase and triglyceride accumulation. Carnosic acid (CA) (isolated from R. officinalis ) and carnasol (isolated from Salvia officinalis [ 71 ] showed lipase inhibitory activity and modulated body weight gain [ 3 ] and lipoprotein-lipase mRNA expression in mouse adipose tissue [ 72 ]. Diterpenoids showed anti-obesity effects by inhibiting adipocyte differentiation.…”

Section: Role Of Natural Products In Obesity: Regulation Of Metabolismmentioning

confidence: 99%

“…Diterpenoids showed anti-obesity effects by inhibiting adipocyte differentiation. Carnosic acid [ 72 , 73 ] and 14-deoxy-11,12- didehydroandrographolide isolated from Andrographis paniculata [ 74 ] are reported to interfere with mitotic clonal expansion, block the expression C/EBPα and PPAR-α, reduce lipoprotein mRNA expression via tumor necrosis factor (TNF-α) and interleukin-6, alter the ratio of different C/EBP-β proteins, and activate the mTOR pathways. In a study on the geranylgeraniol (alcoholic derivatives of diterpenoids), which are mostly found in some herbs and fruits, it was reported that they activate human PPARα and PPARγ in CV1 cells and regulate the expression of target genes mainly responsible for lipid metabolism in 3T3-L1 cells and Hep G2 [ 75 ].…”

Section: Role Of Natural Products In Obesity: Regulation Of Metabolismmentioning

confidence: 99%

A Review on Obesity Management through Natural Compounds and a Green Nanomedicine-Based Approach

et al. 2021

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Obesity is a serious health complication in almost every corner of the world. Excessive weight gain results in the onset of several other health issues such as type II diabetes, cancer, respiratory diseases, musculoskeletal disorders (especially osteoarthritis), and cardiovascular diseases. As allopathic medications and derived pharmaceuticals are partially successful in overcoming this health complication, there is an incessant need to develop new alternative anti-obesity strategies with long term efficacy and less side effects. Plants harbor secondary metabolites such as phenolics, flavonoids, terpenoids and other specific compounds that have been shown to have effective anti-obesity properties. Nanoencapsulation of these secondary metabolites enhances the anti-obesity efficacy of these natural compounds due to their speculated property of target specificity and enhanced efficiency. These nanoencapsulated and naive secondary metabolites show anti-obesity properties mainly by inhibiting the lipid and carbohydrate metabolizing enzymes, suppression of adipogenesis and appetite, and enhancing energy metabolism. This review focuses on the plants and their secondary metabolites, along with their nanoencapsulation, that have anti-obesity effects, with their possible acting mechanisms, for better human health.

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Nanoemulsions improve the efficacy of turmeric in palmitate- and high fat diet-induced cellular and animal models

Cited by 12 publications

References 36 publications

Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies

Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies

Comparative effects of nanoemulsions loaded with duck oil and lard oil on palmitate‐induced lipotoxicity

A Review on Obesity Management through Natural Compounds and a Green Nanomedicine-Based Approach

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