Nanoclays for Biomedical Applications

Peña-Parás, Laura; Sánchez-Fernández, J.A.; Vidaltamayo, Román

doi:10.1007/978-3-319-48281-1_50-1

Cited by 27 publications

(23 citation statements)

References 96 publications

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“…Its chemical formula is (Ca, Na, H) (Al, Mg, Fe, Zn)2(Si, Al)4O10(OH)2-xH2O. There are both natural and synthetic, and their structures consist of alternating tetrahedral SiO2 and octahedral AlO6 sheets with varying ratios 80,81 .…”

Section: Bio-claysmentioning

confidence: 99%

See 1 more Smart Citation

RNAi Crop Protection Advances

Hernández-Soto¹,

Chacón-Cerdas²

2021

Preprint

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RNAi technology is a versatile, effective, safe, and eco-friendly alternative for crop protection. There is plenty of evidence of its use through Host-induced gene silencing (HIGS) and spray-induced gene silencing (SIGS) techniques to control viruses, bacteria, fungi, insects, and nematodes. As for SIGS, its most significant challenge is achieving stability and avoiding premature degradation of RNAi in the environment or during its absorption in the target organism. One alternative is the encapsulation in liposomes, virus-like particles, polyplex nanoparticles, and bio-clay, which can be obtained through the recombinant production of RNAi in vectors, transgenesis, and micro/nanoencapsulation. The materials must be safe, biodegradable, and stable in multiple chemical environments favoring the controlled release of RNAi. Most of the current research of encapsulated RNAi focuses primarily on oral delivery to control insects by silencing essential genes. The regulation of RNAi technology focuses on risk assessment from different approaches; however, this technology has positive characteristics for its use in agriculture from the economic, environmental, and human health implications. The emergence of alternatives combining RNAi gene silencing with the induction of resistance in crops by elicitation and metabolic control is expected, as well as multiple silencing and biotechnological optimization of its large-scale production.

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Section: Bio-claysmentioning

confidence: 99%

“…The most used raw materials are bentonite, hectorite, montmorillonite, kaolinite, laponite, halloysite, laponite, sepiolite, saponite, and vermiculite. They are low-cost, nontoxic, and charge versatile vehicles 81,82 .…”

Section: Bio-claysmentioning

confidence: 99%

RNAi Crop Protection Advances

Hernández-Soto¹,

Chacón-Cerdas²

2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Its chemical formula is (Ca, Na, H) (Al, Mg, Fe, Zn)2(Si, Al)4O10(OH)2-xH2O. There are both natural and synthetic materials, and their structures consist of alternating tetrahedral SiO2 and octahedral AlO6 sheets with varying ratios 80,81 .…”

Section: Bioclaysmentioning

confidence: 99%

RNAi Crop Protection Advances

Hernández-Soto

Chacón-Cerdas

2021

Preprint

View full text Add to dashboard Cite

RNAi technology is a versatile, effective, safe, and eco-friendly alternative for crop protection. There is plenty of evidence of its use through host-induced gene silencing (HIGS) and spray-induced gene silencing (SIGS) techniques to control viruses, bacteria, fungi, insects, and nematodes. For SIGS, its most significant challenge is achieving stability and avoiding premature degradation of RNAi in the environment or during its absorption by the target organism. One alternative is encapsulation in liposomes, virus-like particles, polyplex nanoparticles, and bioclay, which can be obtained through the recombinant production of RNAi in vectors, transgenesis, and micro/nanoencapsulation. The materials must be safe, biodegradable, and stable in multiple chemical environments, favoring the controlled release of RNAi. Most of the current research on encapsulated RNAi focuses primarily on oral delivery to control insects by silencing essential genes. The regulation of RNAi technology focuses on risk assessment using different approaches; however, this technology has positive economic, environmental, and human health implications for its use in agriculture. The emergence of alternatives combining RNAi gene silencing with the induction of resistance in crops by elicitation and metabolic control is expected, as well as multiple silencing and biotechnological optimization of its large-scale production.

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“…Recent advances in nanotechnology, in combination with an increased understanding of the pathophysiology of wounds, have resulted in the development of several inorganic materials and fillers to assist wound healing ( Figure 4 a) [ 53 , 54 , 55 ]. While fascinating results have been achieved by loading inorganic nanoparticles with organic molecules [ 56 , 57 ], the following sections are focused on purely inorganic nanosystems. To mitigate inflammation, for instance, the antioxidant properties of gold [ 58 ], titanium [ 59 ], palladium and platinum [ 60 ] oxide NPs have been harnessed.…”

Section: Emerging Skin Wound Care Materialsmentioning

confidence: 99%

Uniting Drug and Delivery: Metal Oxide Hybrid Nanotherapeutics for Skin Wound Care

2020

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Wound care and soft tissue repair have been a major human concern for millennia. Despite considerable advancements in standards of living and medical abilities, difficult-to-heal wounds remain a major burden for patients, clinicians and the healthcare system alike. Due to an aging population, the rise in chronic diseases such as vascular disease and diabetes, and the increased incidence of antibiotic resistance, the problem is set to worsen. The global wound care market is constantly evolving and expanding, and has yielded a plethora of potential solutions to treat poorly healing wounds. In ancient times, before such a market existed, metals and their ions were frequently used in wound care. In combination with plant extracts, they were used to accelerate the healing of burns, cuts and combat wounds. With the rise of organic chemistry and small molecule drugs and ointments, researchers lost their interest in inorganic materials. Only recently, the advent of nano-engineering has given us a toolbox to develop inorganic materials on a length-scale that is relevant to wound healing processes. The robustness of synthesis, as well as the stability and versatility of inorganic nanotherapeutics gives them potential advantages over small molecule drugs. Both bottom-up and top-down approaches have yielded functional inorganic nanomaterials, some of which unite the wound healing properties of two or more materials. Furthermore, these nanomaterials do not only serve as the active agent, but also as the delivery vehicle, and sometimes as a scaffold. This review article provides an overview of inorganic hybrid nanotherapeutics with promising properties for the wound care field. These therapeutics include combinations of different metals, metal oxides and metal ions. Their production, mechanism of action and applicability will be discussed in comparison to conventional wound healing products.

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Nanoclays for Biomedical Applications

Cited by 27 publications

References 96 publications

RNAi Crop Protection Advances

RNAi Crop Protection Advances

RNAi Crop Protection Advances

Uniting Drug and Delivery: Metal Oxide Hybrid Nanotherapeutics for Skin Wound Care

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