Nanoclay–Polyamine Composite Hydrogel for Topical Delivery of Nitric Oxide Gas via Innate Gelation Characteristics of Laponite

Park, Kyungtae; Dawson, Jonathan I.; Oreffo, Richard O.C.; Kim, Yang‐Hee; Hong, Jinkee

doi:10.1021/acs.biomac.0c00086

Cited by 24 publications

(24 citation statements)

References 35 publications

(48 reference statements)

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“…Journal Pre-proof of Na + ions and diffusion from the stacks. Due to the protonation of hydroxyl groups, the edge of the particles is slightly positively charged instead (Park et al, 2020;Šebenik et al, 2020). The mechanism of formation of the extended thixotropic LAP gel structure involves the reaction of LAP particles with hydroxide ions in water, which causes the dissolution of phosphate ions.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

“…Therefore, it is assumed that hydrogen and electrostatic interactions predominantly determine the viscoelastic properties of hydrogel structures even at low concentrations of ionic bonds. In the end, LAP mostly forms electrostatic interactions (Park et al, 2020) which is the main reason why it has important effect on crosslink density in mixtures with anionic polymers. In the end, the combined use of rheology and LF-NMR enables understanding the polymer-polymer interactions in hydrogel network, which were exploited to develop a new equation for calculation the crosslink density of complex hydrogel systems.…”

Section: Introductionmentioning

confidence: 99%

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Polysaccharide-based hydrogels crosslink density equation: A rheological and LF-NMR study of polymer-polymer interactions

Kopač

Abrami

Grassi

et al. 2022

Carbohydrate Polymers

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Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polysaccharide-based hydrogels crosslink density equation: A rheological and LF-NMR study of polymer-polymer interactions

Kopač

Abrami

Grassi

et al. 2022

Carbohydrate Polymers

View full text Add to dashboard Cite

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“…Laponite is inclined to form house of cards structure based on edge-face attractive interactions between nanosheets. [31] Thus, the poor dispersion weakened mechanical strength of organohydrogels. HA-CA chains intertwined with PAM chains to form a hybrid crosslinked polymer network by multiple hydrogen bond interactions, therefore improving the toughness and stretchability as well as endowing the organohydrogels with excellent self-healing ability.…”

Section: Mechanical Properties and Self-healing Capabilities Of The O...mentioning

confidence: 99%

Environment Adaptable Nanocomposite Organohydrogels for Multifunctional Epidermal Sensors

Xie

Gao

et al. 2022

Adv Materials Inter

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The new generations of wearable materials need to concurrently possess satisfactory biocompatibility and conformability with skin. Different from electronic conductors, ionic conductors report signals using ions like human skin. [3] Ionic conductors can perform many functions that are difficult for electronic conductors. Remarkably, high elastic deformation, high stretchability, and biocompatibility are important parameters for the new-generation ionic conductor applications. [2,4] A flexible device that uses ions as a carrier can be called ionic skin (i-skin). [5] Typical i-skin adopted hydrogel as elastic matrix and deliquescent salts to provide ions such as NaCl, [6] KCl, [7] FeCl 3 , [8] etc. Nonetheless, the water-based materials are particularly sensitive to humidity and temperature, which inevitably leads to dehydration or deliquescent, or even freezing and thus limits the long-term stability of ionic hydrogel conductors. Although the introduction of salts can improve the freezing tolerance of hydrogels, high concentration of ions tends to destroy the interaction inside the network such as hydrogen bonding and ionic bonding which resulting in the poor mechanical strength. [6,9] Ionogel conductors have emerged as another optional materials due to their nonvolatility, high thermal stability, and low temperature resistance. [10,11] However, the inherent toxicity of ionic liquids is a hidden danger for wearable devices which contact with living organism.Natural skin can maintain its flexibility and functionality in harsh environments like freezing and over-heating. For instance, rainbow smelt (Osmerus mordax) have the ability to adapt to very cold water temperatures. This is because their tissues express anti-freeze proteins and glycerol to prevent freezing at sub-zero temperatures. [12] Especially, glycerol (1,2,3-propanetriol or glycerin) as a transparent, odorless and nontoxic liquid, has been widely used in food, cosmetics and pharmaceuticals. After introducing glycerol into water, the hydrogen bonds between H 2 O molecules was disrupted and strong hydrogen bonds were formed between H 2 O molecules and glycerol molecules in the binary solution. [13] Benefitting from this interaction, the obtained organohydrogels can be stored in dry air or low temperature for a long time without losing their mass and flexibility. [14] For instance, anti-freezing conductive double-network organohydrogels were fabricated by soaking a poly(2-acrylamido-2-methylpropane sulfonic Electronic skins, as a revolution in artificial intelligence, have drawn intensive attention in smart prosthetic devices, wearable health monitors and intelligent robot manufacturing. Conductive hydrogels as building blocks have been highlighted in artificial skin research. Nevertheless, the main challenges of hydrogel-based electronics are poor temperature tolerance, weak mechanical robustness and limited stretchability. Herein, an organohydrogel is fabricated with "soft and hard" synergistic networks by combining "soft" polyacryl amide (PAM) and catec...

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“…It has been reported to provide desirable mechanical properties and degradation kinetics [41]. Finally, a novel Laponite nanoclay has been proposed as a NO-donor carrier because it can potentially prevent leaching and release controlled amounts of NO• [118]. The development and implementation of these carriers could eventually offset the current challenges of NO-releasing platforms.…”

Section: Future Perspectivesmentioning

confidence: 99%

Synthetic, Natural, and Semisynthetic Polymer Carriers for Controlled Nitric Oxide Release in Dermal Applications: A Review

2021

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Nitric oxide (NO•) is a free radical gas, produced in the human body to regulate physiological processes, such as inflammatory and immune responses. It is required for skin health; therefore, a lack of NO• is known to cause or worsen skin conditions related to three biomedical applications— infection treatment, injury healing, and blood circulation. Therefore, research on its topical release has been increasing for the last two decades. The storage and delivery of nitric oxide in physiological conditions to compensate for its deficiency is achieved through pharmacological compounds called NO-donors. These are further incorporated into scaffolds to enhance therapeutic treatment. A wide range of polymeric scaffolds has been developed and tested for this purpose. Hence, this review aims to give a detailed overview of the natural, synthetic, and semisynthetic polymeric matrices that have been evaluated for antimicrobial, wound healing, and circulatory dermal applications. These matrices have already set a solid foundation in nitric oxide release and their future perspective is headed toward an enhanced controlled release by novel functionalized semisynthetic polymer carriers and co-delivery synergetic platforms. Finally, further clinical tests on patients with the targeted condition will hopefully enable the eventual commercialization of these systems.

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Nanoclay–Polyamine Composite Hydrogel for Topical Delivery of Nitric Oxide Gas via Innate Gelation Characteristics of Laponite

Cited by 24 publications

References 35 publications

Polysaccharide-based hydrogels crosslink density equation: A rheological and LF-NMR study of polymer-polymer interactions

Polysaccharide-based hydrogels crosslink density equation: A rheological and LF-NMR study of polymer-polymer interactions

Environment Adaptable Nanocomposite Organohydrogels for Multifunctional Epidermal Sensors

Synthetic, Natural, and Semisynthetic Polymer Carriers for Controlled Nitric Oxide Release in Dermal Applications: A Review

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