Nano-delivery system targeting to cancer stem cell cluster of differentiation biomarkers

Mokhtarzadeh, Ahad; Hassanpour, Soodabeh; Vahid, Zahra Farajzadeh; Hejazi, Maryam; Hashemi, Maryam; Ranjbari, Javad; Tabarzad, Maryam; Noorolyai, Saeed; Guárdia, Miguel de la

doi:10.1016/j.jconrel.2017.09.028

Cited by 36 publications

(24 citation statements)

References 262 publications

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“…Also, surface functionalization of PS can be extensively modified and tailored using the high flexibility and customizability of BCP [23–25]. For example, the surface conjugation of various ligands can enable PS to function as targeted drug carriers that enhance the selective recognition of specific cells or tissues, thus optimizing their pharmacokinetics and biodistribution [26, 27].…”

Section: Introductionmentioning

confidence: 99%

Sequential intracellular release of water-soluble cargos from Shell-crosslinked polymersomes

Bobbala

et al. 2018

Journal of Controlled Release

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Polymer vesicles, i.e. polymersomes (PS), present unique nanostructures with an interior aqueous core that can encapsulate multiple independent cargos concurrently. However, the sequential release of such co-loaded actives remains a challenge. Here, we report the rational design and synthesis of oxidation-responsive shell-crosslinked PS with capability for the controlled, sequential release of encapsulated hydrophilic molecules and hydrogels. Amphiphilic brush block copolymers poly(oligo(ethylene glycol) methyl ether methacrylate)-b-poly(oligo(propylene sulfide) methacrylate) (POEGMA-POPSMA) were prepared to fabricate PS via self-assembly in aqueous solution. As a type of unique drug delivery vehicle, the interior of the PS was co-loaded with hydrophilic molecules and water-soluble poly(N-isopropylacrylamide) (PNIPAM) conjugates. Due to the thermosensitivity of PNIPAM, PNIPAM conjugates within the PS aqueous interior underwent a phase transition to form hydrogels in situ when the temperature was raised above the lower critical solution temperature (LCST) of PNIPAM. Via control of the overall shell permeability by oxidation, we realized the sequential release of two water-soluble payloads based on the assumption that hydrogels have much smaller membrane permeability than that of molecular cargos. The ability to control the timing of release of molecular dyes and PNIPAM-based hydrogels was also observed within live cells. Furthermore, leakage of hydrogels from the PS was effectively alleviated in comparison to molecular cargos, which would facilitate intracellular accumulation and prolonged retention of hydrogels within the cell cytoplasm. Thus, we demonstrate that the integration of responsive hydrogels into PS with crosslinkable membranes provides a facile and versatile technique to control the stability and release of water-soluble cargos for drug delivery purposes.

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Section: Introductionmentioning

confidence: 99%

Sequential intracellular release of water-soluble cargos from Shell-crosslinked polymersomes

Bobbala

et al. 2018

Journal of Controlled Release

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“…[17][18][19][20][21][22][23] Although the EPR-based passive targeting has been a pillar for the evolution of macromolecular anticancer therapy, it is applicable only for macromolecules larger than 40 kD [17] and, thereby, there is a need for alternative approaches for smaller drugs to gain long circulation, active targeting, and more efficient drug delivery. [24,25] To straighten out these drawbacks, the application of cell membrane coated nanoparticles (NPs) is a novel strategy for drug delivery in which NPs are coated and/or camouflaged with cell membranes for the effective delivery of therapeutic agents. Hence, most of the newly developed modalities are largely focus on active targeting to achieve more efficient delivery of drugs, genes, and theranostics to the sites of interest as well as elevated quantity of drug accumulation in the target cell(s).…”

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confidence: 99%

Immune Cell Membrane‐Coated Biomimetic Nanoparticles for Targeted Cancer Therapy

Oroojalian

Beygi

Baradaran

et al. 2021

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Cancer is one of the preeminent causes of morbidity and mortality across the world, with a remarkable burden and strain on individuals and communities. [1] Several conventional and novel modalities have been employed in recent decades to overcome therapeutic challenges of cancer, depending on the Nanotechnology has provided great opportunities for managing neoplastic conditions at various levels, from preventive and diagnostic to therapeutic fields. However, when it comes to clinical application, nanoparticles (NPs) have some limitations in terms of biological stability, poor targeting, and rapid clearance from the body. Therefore, biomimetic approaches, utilizing immune cell membranes, are proposed to solve these issues. For example, macrophage or neutrophil cell membrane coated NPs are developed with the ability to interact with tumor tissue to suppress cancer progression and metastasis. The functionality of these particles largely depends on the surface proteins of the immune cells and their preserved function during membrane extraction and coating process on the NPs. Proteins on the outer surface of immune cells can render a wide range of activities to the NPs, including prolonged blood circulation, remarkable competency in recognizing antigens for enhanced targeting, better cellular interactions, gradual drug release, and reduced toxicity in vivo. In this review, nano-based systems coated with immune cells-derived membranous layers, their detailed production process, and the applicability of these biomimetic systems in cancer treatment are discussed. In addition, future perspectives and challenges for their clinical translation are also presented.

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“…However, it is possible to differentiate CSCs from other common cancer cells and normal stem cells on the strength of their specific surface biomarkers 65 . There have been quite a lot of biomarkers described, such as CD44, CD133, and epithelial cell adhesion molecule (EpCAM) 66 . The strong binding between the existing biomarkers and their specific antibodies provides enhanced targeting based on the EPR effect, which is accompanied by a high cellular uptake and increased drug concentration in CSCs 13 , 38 , 67 .…”

Section: Ddss For Direct Targeting Of Cscs At the Cellular Levelmentioning

confidence: 99%

Recent advances in drug delivery systems for targeting cancer stem cells

Duan

Liu

Gao

et al. 2021

Acta Pharmaceutica Sinica B

161

107

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Cancer stem cells (CSCs) are a subpopulation of cancer cells with functions similar to those of normal stem cells. Although few in number, they are capable of self-renewal, unlimited proliferation, and multi-directional differentiation potential. In addition, CSCs have the ability to escape immune surveillance. Thus, they play an important role in the occurrence and development of tumors, and they are closely related to tumor invasion, metastasis, drug resistance, and recurrence after treatment. Therefore, specific targeting of CSCs may improve the efficiency of cancer therapy. A series of corresponding promising therapeutic strategies based on CSC targeting, such as the targeting of CSC niche, CSC signaling pathways, and CSC mitochondria, are currently under development. Given the rapid progression in this field and nanotechnology, drug delivery systems (DDSs) for CSC targeting are increasingly being developed. In this review, we summarize the advances in CSC-targeted DDSs. Furthermore, we highlight the latest developmental trends through the main line of CSC occurrence and development process; some considerations about the rationale, advantages, and limitations of different DDSs for CSC-targeted therapies were discussed.

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Nano-delivery system targeting to cancer stem cell cluster of differentiation biomarkers

Cited by 36 publications

References 262 publications

Sequential intracellular release of water-soluble cargos from Shell-crosslinked polymersomes

Sequential intracellular release of water-soluble cargos from Shell-crosslinked polymersomes

Immune Cell Membrane‐Coated Biomimetic Nanoparticles for Targeted Cancer Therapy

Recent advances in drug delivery systems for targeting cancer stem cells

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