Nano-bioactive glass incorporated polymeric apatite/tricalcium phosphate cement composite supports proliferation and osteogenic differentiation of human adipose-derived stem/stromal cells

Thaitalay, Paritat; Giannasi, Chiara; Niada, Stefania; Thongsri, Oranich; Dangviriyakul, Rawee; Srisuwan, Sawitri; Suksaweang, Sanong; Brini, A.T.; Rattanachan, Sirirat

doi:10.1016/j.mtcomm.2022.103590

Cited by 5 publications

(8 citation statements)

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“…Sonuç olarak hazırlanan Nano-BG modifiye PAA-apatit/β-TCP'nin, tıbbi uygulamalar ve ortopedi için umut verici bir biyomateryal olabileceği şeklinde yorumlanmıştır. 47,48 Sodyum diamin florür (SDF), anti-çürük özellik göstermekle birlikte diş üzerinde gümüş fosfat çökmesine bağlı olarak diş üzerinde lekelenmelere neden olmaktadır. Bu olumsuzluğu önlemek amacıyla nanogümüş florür [nano-silver fluoride (NSF)], diş çürüklerinde SDF'ye alternatif olarak geliştirilmiştir.…”

Section: Tri̇kalsi̇yum Si̇li̇katunclassified

“…NSF bir nanofarmasötik yaklaşımdır ve bileşimi SDF'ye benzer olup içeriğinde gümüş NP'leri bulundurmaktadır. 48,49 Başka bir çalışmada, tedavide NSF uygulamanın basit ve ekonomik olduğu bildirilmiştir. 49,50 HA İÇİN NANOfARMASÖTİK YAKLAŞIMLAR Literatürde, HA NP'lerin dişlerin mineral yapısına benzerliği, yüksek biyoaktiviteye ve biyouyumlulukları en büyük avantajları olarak değerlendirilmektedir.…”

Section: Tri̇kalsi̇yum Si̇li̇katunclassified

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Remineralization Agents and Nanopharmaceutical Approaches That Have an Important Place in Dental Therapies and Preventive Dentistry: Traditional Review

ÖZTÜRK¹,

ARSLAN²

2023

J Lit Pharm Sci

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Section: Tri̇kalsi̇yum Si̇li̇katunclassified

Remineralization Agents and Nanopharmaceutical Approaches That Have an Important Place in Dental Therapies and Preventive Dentistry: Traditional Review

ÖZTÜRK¹,

ARSLAN²

2023

J Lit Pharm Sci

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Section: Introductionmentioning

confidence: 99%

“…Mesoporous bioactive glasses (MBGs) are promising materials for regenerative medicine, due to their favorable properties, including biocompatibility, osteoinduction, and degradability [ 9 , 10 , 11 ]. These key properties, along with their surface area, pore structure, and pore volume, are highly recommended for tissue regeneration [ 9 , 10 , 11 , 12 , 13 ]. However, systematic studies on the performance of MBG/CPC composite bone cement covering a wide range of possible drug-loading compositions are lacking [ 12 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, systematic studies on the performance of MBG/CPC composite bone cement covering a wide range of possible drug-loading compositions are lacking [ 12 , 13 , 14 , 15 , 16 ]. The key features of MBGs are a highly ordered channel-like pore systems in the 5–20 nm range, a large pore volume, and significantly increased specific surface area to facilitate cell adhesion, proliferation, and drug impregnation; they also show enhanced biodegradation [ 10 , 11 , 12 , 13 ]. By controlling MBG degradation, ion and drug release can be controlled to modulate tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

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Injectability, Processability, Drug Loading, and Antibacterial Activity of Gentamicin-Impregnated Mesoporous Bioactive Glass Composite Calcium Phosphate Bone Cement In Vitro

Chu

Huang

et al. 2022

Biomimetics

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Calcium phosphate cement (CPC) is similar to bone in composition and has plasticity, while mesoporous bioactive glass (MBG) has the advantage of releasing Si, which can promote osteogenic properties and drug loading capacity. A sol–gel-prepared MBG micro-powder (mMBG) and further impregnated antibiotic gentamicin sulfate (Genta@mMBG: 2, 3, and 4 mg/mL) antibiotic were added to CPC at different weight ratios (5, 10, and 15 wt.%) to study CPC’s potential clinical applications. Different ratios of mMBG/CPC composite bone cement showed good injectability and disintegration resistance, but with increasing mMBG addition, the working/setting time and compressive strength decreased. The maximum additive amount was 10 wt.% mMBG due to the working time of ~ 5 min, the setting time of ~ 10 min, and the compressive strength of ~51 MPa, indicating that it was more suitable for clinical surgical applications than the other groups. The 2Genta@mMBG group loaded with 2 mg/mL gentamicin had good antibacterial activity, and the 10 wt.% 2Genta@mMBG/CPC composite bone cement still had good antibacterial activity but reduced the initial release of Genta. 2Genta@mMBG was found to have slight cytotoxicity, so 2Genta@mMBG was composited into CPC to improve the biocompatibility and to endow CPC with more advantages for clinical application.

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Primary human osteoblast and mesenchymal stem cell responses to apatite/tricalcium phosphate bone cement modified with polyacrylic acid and bioactive glass

Thaitalay

Thongsri

Dangviriyakul

et al. 2023

J Biomedical Materials Res

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In this work, three different modified cements, control apatite/beta-tricalcium phosphate cement (CPC), polymeric CPC (p-CPC), and bioactive glass added polymeric cement (p-CPC/BG) were evaluated regarding their physical properties and the responses of primary human osteoblast cells (HObs) and mesenchymal stem cells (MSCs). Although polyacrylic acid (PAA) increased compressive strength and Young's modulus of the cement, it could cause poor apatite phase formation, a prolonged setting time, and a lower degradation rate. Consequently, bioactive glass (BG) was added to PAA/cement to improve its physical properties, such as compressive strength, Young's modulus, setting time, and degradation. For in vitro testing, HObs viability was assessed under two culture systems with cement-preconditioned medium (indirect) and with cement (direct). HObs viability was examined in direct contact with cements treated by different prewashing conditions. HObs presented a more well spread morphology on cement soaked in medium overnight, as compared to other cements with no treatment and washing in PBS. In addition, the proliferation, differentiation, and total collagen production of both HObs and MSCs adhered to the cement were detected. Cells showed excellent proliferation on PAA/cement and PAA/BG/cement. Furthermore, the higher released Si ion and lower acidosis of PAA/BG/cementconditioned medium resulted in an increase in osteogenic differentiation (HObs and MSCs) and enhanced collagen production (HObs in osteogenic medium and MSCs in control medium). Therefore, our findings suggest that BG incorporated PAA/apatite/ β-TCP cement could be a promising formula for bone repair applications.apatite bone cement, bioactive glass, calcium phosphate cement, osteoblast, polyacrylic acid, polymeric calcium phosphate cement, stem cells | INTRODUCTIONOsteoporosis, one of the common diseases of the aging population, is one orthopedic issue that frequently requires treatment with a bone replacement material. 1 Synthetic bone graft substitutes are attractive due to the limited availability of autografts and their associated costs. 2,3 Calcium phosphate cements (CPCs) are one of the most promising biomaterials for bone grafting applications due to their

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Nano-bioactive glass incorporated polymeric apatite/tricalcium phosphate cement composite supports proliferation and osteogenic differentiation of human adipose-derived stem/stromal cells

Cited by 5 publications

References 65 publications

Remineralization Agents and Nanopharmaceutical Approaches That Have an Important Place in Dental Therapies and Preventive Dentistry: Traditional Review

Remineralization Agents and Nanopharmaceutical Approaches That Have an Important Place in Dental Therapies and Preventive Dentistry: Traditional Review

Injectability, Processability, Drug Loading, and Antibacterial Activity of Gentamicin-Impregnated Mesoporous Bioactive Glass Composite Calcium Phosphate Bone Cement In Vitro

Primary human osteoblast and mesenchymal stem cell responses to apatite/tricalcium phosphate bone cement modified with polyacrylic acid and bioactive glass

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