Naloxone in Clonidine Toxicity

Use of Naloxone for Clonidine Intoxication in the Pediatric Age Group

“…[11][12][13] Positive responses to naloxone, consisting of improvement in heart rate, increased respiratory rate, or increased blood pressure, have been reported. [11][12][13] Positive responses to naloxone, consisting of improvement in heart rate, increased respiratory rate, or increased blood pressure, have been reported.…”

Comparison of Clinical, Hematologic, Biochemical Findings in Amitraz Poisoning and the Effect of Naloxone to the Treatment: Experimental Study

“…Bazı çalışmalarda nalokson ile tedavide önemli yanıtlar alınmıştır, ancak yanıt alınamayan çalışmalar da vardır. [5][6][7] Köpekler üze-rinde yapılan bir deneysel çalışmada 27 yohimbin ve diğer dört antagonistin etkileri incelenmiştir. 3 mg/kg amitraz damar içi yoldan verildikten 5 dakika sonra 0,1 mg/kg yohimbin, 3,3 mg/kg tolazolin, 1 mg/kg prazosin, 0,04 mg/kg atropin ve 1 mg/kg nalokson verilmiş ve mekikten sakınma (shuttleavoidance) yanıtlarına bakılmıştır.…”

Clonidine overdose in childhood: Implications of increased prescribing

“…[5] There have been several other single case reports documenting successful naloxone therapy, however, it should be noted that naloxone therapy remains controversial. [5,9,14–16] It has been suggested that hypertension is more likely to occur after the use of naloxone. [5,9]…”

“…[5] We speculate that part of this difference may relate to our use of naloxone, which has been advocated as a specific antidote for the CNS effects of clonidine. [5,9,14,15] Five of our patients were treated with naloxone and four are likely to have avoided mechanical ventilation because of its use. These patients received a bolus dose of 50–100 mcg/kg followed by an infusion.…”