2016
DOI: 10.18632/aging.101140
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Abstract: The naked mole-rat (NMR) Heterocephalus glaber is an exceptionally long-lived rodent, living up to 32 years in captivity. This extended lifespan is accompanied by a phenotype of negligible senescence, a phenomenon of very slow changes in the expected physiological characteristics with age. One of the many consequences of normal aging in mammals is the devastating and progressive loss of skeletal muscle, termed sarcopenia, caused in part by respiratory enzyme dysfunction within the mitochondria of skeletal musc… Show more

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Cited by 25 publications
(20 citation statements)
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References 42 publications
(46 reference statements)
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“…Two mitochondrial genes ( ND5 and ATP8 ) in the OXPHOS pathway were exclusively identified to be under positive selection in the naked mole rat, suggesting that mitochondria play a role in subterranean hypoxia-tolerance. Various studies have investigated hypoxia-tolerance in the naked mole rat ( Fang et al, 2014 ; Park et al, 2017 ), but its mitochondrial energetics remains largely unexplored, which are likely critical to its hypoxia-tolerance and extraordinary lifespan ( Stoll et al, 2016 ).…”
Section: Discussionmentioning
confidence: 99%
“…Two mitochondrial genes ( ND5 and ATP8 ) in the OXPHOS pathway were exclusively identified to be under positive selection in the naked mole rat, suggesting that mitochondria play a role in subterranean hypoxia-tolerance. Various studies have investigated hypoxia-tolerance in the naked mole rat ( Fang et al, 2014 ; Park et al, 2017 ), but its mitochondrial energetics remains largely unexplored, which are likely critical to its hypoxia-tolerance and extraordinary lifespan ( Stoll et al, 2016 ).…”
Section: Discussionmentioning
confidence: 99%
“…Finally, adaptations in genes involved in mitochondrial function may limit damage due to reactive oxygen species and preserve mitochondria throughout lifespan. The mitochondria of long-lived naked mole rats exhibit low rates of hydrogen peroxide production from complex I of the electron transport chain (Lambert et al, 2007) and maintain stable activity of complex IV, which preserves healthy muscle throughout lifespan (Stoll et al, 2016). Interestingly, the short-lived African killifish also exhibits variants under positive selection in components of mitochondrial complex I (e.g., NADH dehydrogenase 1 beta subcomplex 5 [NDUFB5]) (Sahm et al, 2017).…”
Section: Aging and Longevity Through The Lens Of Evolutionmentioning
confidence: 99%
“…Some of the changes at the cellular level, seen in aged muscle cells include accumulation of intra or extracellular lipids; misfolding of structural and contractile proteins, and mitochondrial dysfunction [ 10 ]. Current evidence suggests that the decreases in mitochondrial respiratory enzymes, especially complex IV [ 11 ]. the decrease in the mitochondrial content and also increases in Carbonic anhydrases associated with mitochondria [ 12 ] appear to be key factors in the process of muscle aging, as demonstrated by a reduction in both mtDNA copies, and tricarboxylic acid cycle enzymes activity [ 2 ] [ 13 ].…”
Section: Introductionmentioning
confidence: 99%