Nails in sarcoidosis: response to treatment

Nail Sarcoidosis with and without Systemic Involvement: Report of Two Cases

“…In contrast, nail changes are more unusual, ranging from 1 in 400 to 3 in 188 cases, and they are often associated with chronic systemic disease [1,2,4,5]. …”

Nail dystrophy and bony involvement in chronic sarcoidosis

“…15 Differential diagnoses include lichen planus, dermatophytes, histoplasmosis, coccidiomycosis, tuberculosis, amyloidosis, psoriasis, intake of emetine hydrochloride and tetracycline hydrochloride, trauma, and granuloma annulare. 2 A punch biopsy of the proximal nailfold or nail bed is advised for diagnostic purposes. Previous treatment options for nail dystrophy in sarcoidosis included systemic treatment with 10 mg/d of prednisone and 200 mg/d of hydroxychloroquine sulfate, 2 high-potency topical steroids application once daily, 13 and steroid injections into the nailfold.…”

Sarcoidosis

“…[91][92][93][94] Nail sarcoidosis Nail manifestations caused by sarcoidosis include subungual hyperkeratosis, pitting, clubbing, onychorrhexis, trachyonychia, splinter hemorrhages, paronychia, pterygium, onycholysis, nail plate thinning, dactylitis, longitudinal ridging, and nail bed discoloration. [95][96][97] A review of 33 cases of nail sarcoidosis reported that bone cysts were present on radiographic imaging in almost half of the cases and that all had systemic involvement. 95 Therefore, radiologic examination and evaluation for systemic disease is warranted in individuals with sarcoidosis nail dystrophy.…”

“…[95][96][97] A review of 33 cases of nail sarcoidosis reported that bone cysts were present on radiographic imaging in almost half of the cases and that all had systemic involvement. 95 Therefore, radiologic examination and evaluation for systemic disease is warranted in individuals with sarcoidosis nail dystrophy. 70 …”