Nail involvement in histiocytosis X. A 12-year retrospective study

Langerhans cell histiocytosis presenting as fingernail changes

“…As described in the literature, the histologic findings of the lesions in the nail unit of our patient are similar to those described in the cutaneous lesions, which comprise atypical Langerhans cells 5, 6…”

Langerhans Cell Histiocytosis With Involvement of Nails and Lungs in an Adolescent

“…In 6 cases, the outcome was noted to be poor. 5,20,22,23 Involvement of the lungs besides the systemic disease was the remarkable point in these 6 patients similar to our case with recurrent disease. In another 2 reports regarding skin, nail, and lung involvement, the follow-up period was 4 months in 1 of the patients and no follow-up data were available in the second one.…”

Langerhans cell histiocytosis with prominent nail involvement

“…To our knowledge, 21 previous cases of LCH with nail changes have been reported in the literature (Table 1). [4][5][6][9][10][11][12][13][14][15][16][17][18][19][20] As in other studies, 4,14,16,18,19 histopathologic differences between skin and nail lesions of LCH were not observed in our patient, but secondary change of acute inflammatory crusting was seen in the nail specimen.…”

“…Among the largest pediatric series, including 32 patients in the United States and 124 patients in Mexico, no cases of patients with LCH and nail involvement were identified. To our knowledge, 21 previous cases of LCH with nail changes have been reported in the literature (Table ) . As in other studies, histopathologic differences between skin and nail lesions of LCH were not observed in our patient, but secondary change of acute inflammatory crusting was seen in the nail specimen.…”