N-Terminal pro-brain natriuretic peptide in systemic sclerosis: new insights

Elshamy, Hebat-Allah A.; Ibrahim, Saad M.; Farouk, Hanan Mohamed; Moustafa, Afaf A.; Aly, Iman Mohamed; Osman, Wesam M.

doi:10.1684/ejd.2011.1423

Cited by 12 publications

(7 citation statements)

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“…Of note, endostatin-derived peptides have exhibited antifibrotic properties and were able to prevent and reverse dermal TGFβ-induced fibrosis in both ex vivo human skin and in vivo mouse models (42). Similarly, NT-proBNP has a more established link with vascular abnormalities in SSc, particularly with PAH, cardiac damage, and mortality (43), but previous studies have also shown a positive correlation of NT-proBNP with MRSS scores (44)(45)(46).…”

Section: Discussionmentioning

confidence: 99%

Large‐Scale Characterization of Systemic Sclerosis Serum Protein Profile: Comparison to Peripheral Blood Cell Transcriptome and Correlations With Skin/Lung Fibrosis

Bellocchi

Jin

Goldmuntz

et al. 2021

Arthritis & Rheumatology

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Objective. To provide a large-scale assessment of serum protein dysregulation in diffuse cutaneous systemic sclerosis (dcSSc) and to investigate serum protein correlates of SSc fibrotic features. Methods. We investigated serum protein profiles of 66 participants with dcSSc at baseline who were enrolled in the Scleroderma: Cyclophosphamide or Transplant Trial and 66 age-and sex-matched healthy control subjects. A panel of 230 proteins, including several cytokines and chemokines, was investigated. Whole blood gene expression profiling in concomitantly collected samples was performed. Results. Among the participants with dcSSc, the mean disease duration was 2.3 years. All had interstitial lung disease (ILD), and none were being treated with immunosuppressive agents at baseline. Ninety proteins were differentially expressed in participants with dcSSc compared to healthy control subjects. Similar to previous global skin transcript results, hepatic fibrosis, granulocyte and agranulocyte adhesion, and diapedesis were the top overrepresented pathways. Eighteen proteins correlated with the modified Rodnan skin thickness score (MRSS). Soluble epidermal growth factor receptor was significantly down-regulated in dcSSc and showed the strongest negative correlation with the MRSS, being predictive of the score's course over time, whereas α 1-antichymotrypsin was significantly upregulated in dcSSc and showed the strongest positive correlation with the MRSS. Furthermore, higher levels of cancer antigen 15-3 correlated with more severe ILD, based on findings of reduced forced vital capacity and higher scores of disease activity on high-resolution computed tomography. Only 14 genes showed significant differential expression in the same direction in serum protein and whole blood RNA gene expression analyses. Conclusion. Diffuse cutaneous SSc has a distinct serum protein profile with prominent dysregulation of proteins related to fibrosis and immune cell adhesion/diapedesis. The differential expression for most serum proteins in SSc is likely to originate outside the peripheral blood cells.

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Section: Discussionmentioning

confidence: 99%

Large‐Scale Characterization of Systemic Sclerosis Serum Protein Profile: Comparison to Peripheral Blood Cell Transcriptome and Correlations With Skin/Lung Fibrosis

Bellocchi

Jin

Goldmuntz

et al. 2021

Arthritis & Rheumatology

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“…Second, cGMP is also produced by the natriuretic peptide (NP)/ particulate guanylyl cyclase (pGC) pathway, but sGC stimulators do not activate that pathway [44]. However, the contribution of the NP/pGC pathway to cGMP production is unknown, given that the levels of serum natriuretic peptides such as BNP in SSc patients tend to be higher than those in healthy individuals, and PDE5 inhibitors might be more potent cGMP-induction agents than sGC stimulators [45]. In light of these points, the combination of a sGC stimulator and PDE5…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Sildenafil attenuates the fibrotic phenotype of skin fibroblasts in patients with systemic sclerosis

Higuchi

Kawaguchi

Takagi

et al. 2015

Clinical Immunology

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“…According to our results, measuring of BNP in SSc patients could also be useful in the detection of disease severity ( Figure 2 ). Interestingly, Elshamy et al (42) demonstrated that NT-proBNP has potential in estimating SSc severity. Our results expand these previous findings by confirming that BNP can also be used for the same purposes.…”

Section: Discussionmentioning

confidence: 99%

B-Type Natriuretic Peptide as a Marker of Different Forms of Systemic Sclerosis

Nešković

Ristić

Petronijević

et al. 2018

Journal of Medical Biochemistry

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SummaryBackgroundSystemic sclerosis (SSc) is an autoimmune connective tissue disease which affects various tissues and organs, including skin, lungs, kidneys, gastrointestinal tract and cardiovascular system. Cardiac involvement is the most commonly recognized problem and a significant cause of morbidity. The brain natriuretic peptide (BNP) is a previously known marker of elevated cardiovascular risk in SSc, but the levels of BNP in various forms of SSc have not been investigated so far.AimThe aim of our study was to evaluate the influence of SSc on the function of the right ventricle and the right atrium using the echocardiographic parameters. Moreover, we examined the levels of BNP in different forms of SSc as well as the association of disease severity with the plasma concentrations of BNP.MethodsWe included 42 patients with newly diagnosed SSc and patients whose disease had been diagnosed earlier. SSc patients and non-SSc control patients were examined by using echocardiography and the concentrations of BNP were determined.ResultsWe analyzed differences in the parameters of right ventricle (RV) function and right atrium (RA) function between SSc patients and healthy controls. The two groups had similar distribution of gender, but SSc patients were significantly older than controls. RV wall thickness was increased in SSc patients (p<0.001), while right ventricular end-systolic area (RVESA; p=0.408) and right ventricular end-diastolic area (RVEDA; p=0.368) did not differ among the examinees. In contrast, RA minor-axis dimension (p=0.001) and the tricuspid annular plane systolic excursion (TAPSE) (p=0.001) were significantly higher in SSc patients. Also, we analyzed differences in brain natriuretic peptide (BNP) concentrations between diffuse cutaneous systemic sclerosis (DSSc) and limited cutaneous systemic sclerosis (LSSc) patients. DSSc patients had significantly higher concentrations of BNP. We found that levels of BNP were in significant positive correlations with age (p=0.007), disease duration (p=0.023), C reactive protein (CRP) (p=0.032), right ventricle fractional area change (FAC) (p=0.022), pulmonary vascular resistance (PVR) and Rodnan score (p=0.019).ConclusionsGiven the obtained results, the laboratory determination of BNP could be useful in differentiating different forms of systemic sclerosis as well as in predicting the severity of the disease and future cardiovascular complications.

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N-Terminal pro-brain natriuretic peptide in systemic sclerosis: new insights

Cited by 12 publications

References 0 publications

Large‐Scale Characterization of Systemic Sclerosis Serum Protein Profile: Comparison to Peripheral Blood Cell Transcriptome and Correlations With Skin/Lung Fibrosis

Large‐Scale Characterization of Systemic Sclerosis Serum Protein Profile: Comparison to Peripheral Blood Cell Transcriptome and Correlations With Skin/Lung Fibrosis

Sildenafil attenuates the fibrotic phenotype of skin fibroblasts in patients with systemic sclerosis

B-Type Natriuretic Peptide as a Marker of Different Forms of Systemic Sclerosis

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