N-Terminal Pro-B–Type Natriuretic Peptide Plasma Levels as a Potential Biomarker for Cardiac Damage After Radiotherapy in Patients With Left-Sided Breast Cancer

D’Errico, Maria Patrizia; Grimaldi, Luca; Petruzzelli, Maria Fonte; Gianicolo, Emilio Antonio Luca; Tramacere, Francesco; Monetti, Antonio; Placella, Roberto; Pili, Giorgio; Andreassi, Maria Grazia; Sicari, Rosa; Portaluri, Maurizio

doi:10.1016/j.ijrobp.2011.03.058

Cited by 84 publications

(57 citation statements)

References 26 publications

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“…These findings support the notion that subtle forms of myocardial damage not detectable by reduction of LV function can be revealed by circulating biomarkers [36].…”

Section: Imaging Studies Cardiovascular Biomarkers and Radiotherapysupporting

confidence: 86%

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Ionizing radiation and atherosclerosis: Current knowledge and future challenges

2013

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“…These findings support the notion that subtle forms of myocardial damage not detectable by reduction of LV function can be revealed by circulating biomarkers [36].…”

Section: Imaging Studies Cardiovascular Biomarkers and Radiotherapysupporting

confidence: 86%

“…Importantly, higher values of N-terminal pro-Betype natriuretic peptide (NT-proBNP) were found in women with left-sided breast cancer after radiotherapy when compared with non-irradiated leftsided breast cancer patients [36].…”

Section: Imaging Studies Cardiovascular Biomarkers and Radiotherapymentioning

confidence: 99%

Ionizing radiation and atherosclerosis: Current knowledge and future challenges

2013

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“…Soluble corin is detected in human plasma, and its levels are decreased in patients with heart failure (21). In addition, high levels of the pro-form of plasma natriuretic peptides have also been found in cardiovascular disease patients (23). In agreement with these studies, our results demonstrated that corin and the active forms of natriuretic peptides were decreased in response to IR in myocardial cells.…”

Section: Discussionsupporting

confidence: 91%

Involvement of corin downregulation in ionizing radiation-induced senescence of myocardial cells

Kim

Lee

Jung

et al. 2014

International Journal of Molecular Medicine

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Abstract. Radiation-induced heart disease (RIHD) is becoming an increasing concern for patients and clinicians alike due to the use of radiotherapy for the treatment of breast cancer, Hodgkin's lymphoma, pediatric cancer and tumors of the thorax. However, the mechanisms underlying this phenomenon remain largely unknown. As the senescent cell fraction following irradiation is known to increase, in the present study, we investigated whether ionizing radiation (IR) causes the onset of heart disease by inducing cellular senescence in cardiomyocytes. In the present study, we evaluated the effects of IR on HL-1 and H9C2 cells, cells predominantly used in in vitro myocardial cell models. We found that the exposure of the HL-1 and H9C2 cells to IR induced reactive oxygen species (ROS)-mediated cellular senescence, as shown by staining of senescence-associated β-galactosidase (SA-β-gal). The levels of ROS in irradiated cells were determined using the fluorescent dye, 2' , 7'-dichlorodihydrofluorescein diacetate (DCF-DA). Notably, the expression of corin, a cardiac protease that is essential for the proteolytic cleavage of natriuretic peptides, was significantly decreased following the exposure of the cells to IR. Importantly, the knockdown of corin by RNA interference enhanced IR-induced senescence. On the contrary, the overexpression of natriuretic peptides reversed the IR-induced senescence. Taken together, our data suggest that defects in corin function and the inhibition of natriuretic peptides following exposure to IR may contribute to the development of RIHD through the acceleration of cellular senescence.

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“…[23][24][25][26][27] For example, using single-photon emission computed tomography, volume-dependent myocardial perfusion defects have been demonstrated following left breast irradiation. These abnormalities remain prevalent more than 5 years following RT and correlate with both cardiac symptoms and early wall motion abnormalities.…”

Section: Discussionmentioning

confidence: 99%