N-Substituted calothrixin B derivatives inhibited the proliferation of HL-60 promyelocytic leukemia cells

Hatae, Noriyuki; Satoh, Risa; Chiba, Hitomi; Osaki, Takahiro; Nishiyama, Takashi; Ishikura, Minoru; Abe, Takumi; Hibino, Satoshi; Choshi, Tominari; Okada, Chiaki; Toyota, Eiji

doi:10.1007/s00044-014-1061-6

Cited by 40 publications

(6 citation statements)

References 19 publications

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“…The calothrixins are quinone-based natural products isolated from Calothrix cyanobacteria that show potent antiproliferative properties against several cancer cell lines [ 258 ]. Calothrixin B displayed antiproliferative activity against HCT-116 colon cancer cell line (IC 50 0.32 µM) [ 72 ]. Malyngamides are small amides produced by marine cyanobacteria; malyngamides isolated from Lyngbya majuscule (malyngamide C and 8-epi-malyngamide C) were found to be cytotoxic to HT29 colon cancer cells (IC 50 5.2 μM and 15.4 μM, respectively) [ 71 ].…”

Section: Colorectal Cancer As a Consequence Of Chronic Inflammatormentioning

confidence: 99%

Bioactive Compounds Isolated from Microalgae in Chronic Inflammation and Cancer

et al. 2015

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The risk of onset of cancer is influenced by poorly controlled chronic inflammatory processes. Inflammatory diseases related to cancer development include inflammatory bowel disease, which can lead to colon cancer, or actinic keratosis, associated with chronic exposure to ultraviolet light, which can progress to squamous cell carcinoma. Chronic inflammatory states expose these patients to a number of signals with tumorigenic effects, including nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPK) activation, pro-inflammatory cytokines and prostaglandins release and ROS production. In addition, the participation of inflammasomes, autophagy and sirtuins has been demonstrated in pathological processes such as inflammation and cancer. Chemoprevention consists in the use of drugs, vitamins, or nutritional supplements to reduce the risk of developing or having a recurrence of cancer. Numerous in vitro and animal studies have established the potential colon and skin cancer chemopreventive properties of substances from marine environment, including microalgae species and their products (carotenoids, fatty acids, glycolipids, polysaccharides and proteins). This review summarizes the main mechanisms of actions of these compounds in the chemoprevention of these cancers. These actions include suppression of cell proliferation, induction of apoptosis, stimulation of antimetastatic and antiangiogenic responses and increased antioxidant and anti-inflammatory activity.

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Section: Colorectal Cancer As a Consequence Of Chronic Inflammatormentioning

confidence: 99%

Bioactive Compounds Isolated from Microalgae in Chronic Inflammation and Cancer

et al. 2015

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“…It has shown antitumor activity against human HeLa cancer cells at nanomolar concentrations [ 28 ]. Besides this, calothrixin B displayed antiproliferative activity against the HCT-116 colon cancer cell line with an IC 50 value of 0.32 µM [ 29 ]. Recently, a series of calothrixin B analogs have been synthesized that inhibit cancer cell growth by extensive DNA damage followed by apoptotic cell death.…”

Section: Anticancer Potential Of Bioactive Compounds From Cyanobacmentioning

confidence: 99%

Cyanobacteria as Natural Therapeutics and Pharmaceutical Potential: Role in Antitumor Activity and as Nanovectors

et al. 2021

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Cyanobacteria (blue-green microalgae) are ubiquitous, Gram-negative photoautotrophic prokaryotes. They are considered as one of the most efficient sources of bioactive secondary metabolites. More than 50% of cyanobacteria are cultivated on commercial platforms to extract bioactive compounds, which have bene shown to possess anticancer activity. The chemically diverse natural compounds or their analogues induce cytotoxicity and potentially kill a variety of cancer cells via the induction of apoptosis, or altering the activation of cell signaling, involving especially the protein kinase-C family members, cell cycle arrest, mitochondrial dysfunctions and oxidative damage. These therapeutic properties enable their use in the pharma and healthcare sectors for the betterment of future generations. This review provides a baseline overview of the anti-cancerous cyanobacterial bioactive compounds, along with recently introduced nanomaterials that could be used for the development of new anticancer drugs to build a healthy future for mankind.

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“…Cell viability was assessed using the WST-1 assay method 30 for HL-60 and the MTT assay method 31 for HCT-116. GEM, IRI, and their degradation mixtures after the ozone treatment were applied to the cell suspensions according to the previous procedures, 32 and as such the concentrations of the drugs were 10 and 100 µM. The concentrations of the degradation mixtures are expressed based on the amounts of their parent drugs before the ozonation.…”

Section: Cytotoxicity Testmentioning

confidence: 99%

Degradation and inactivation efficacy of ozone water for antineoplastic drugs in hospital settings

Kato

Mitome

Shigematsu

et al. 2021

J Oncol Pharm Pract

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Purpose Occupational exposure to antineoplastic drugs in hospital settings is recognized to be hazardous, and as such environmental decontamination including degradation and inactivation of such drugs is recommended. To data, although various agents such as oxidants have been reported to be useful for decontamination, simpler, safer, and more convenient methods are required. In this study, the degradation and inactivation efficacy of ozone water, which has newly been introduced for decontamination of antineoplastic drugs in spills, was investigated for formulations of gemcitabine, irinotecan, and paclitaxel. Methods Antineoplastic formulations (medicinal ingredient: ∼1.5 μmol) were mixed with 50 mL of ozone water (>4 mg/L). The reactions were monitored by high-performance liquid chromatography, and the degradation mixtures were analyzed by 1H nuclear magnetic resonance spectroscopy in order to obtain the structural information of the degradation products. The formulations of gemcitabine and irinotecan and those degradation mixtures were evaluated for their mutagenicity using the Ames test and cytotoxicity against human cancer cells. Results gemcitabine and irinotecan were found to be readily degraded by the ozone treatment, and their active sites were suggested to be degraded. In contrast, paclitaxel was hard to be decomposed, possibly owing to the consumption of ozone by the polyoxyethylene castor oil added as a pharmaceutical additive of the formulation. No significant mutagenic changes of Salmonella typhimurium strains used for the Ames test were observed for the samples within the concentration ranges examined. The ozone treatment showed obvious increases in cell viability for gemcitabine formulation, and mild increases for irinotecan formulation. Conclusions Ozone water was shown to be effective as a decomposition agent for the antineoplastic drug formulations examined, although the efficacy depends on the chemical structures of the drugs and the pharmaceutical additives. It was also suggested that ozone treatment has a tendency to decrease the toxicity of the antineoplastic drug formulations. As such, further studies are required in order to clarify the effects and application limitations of ozone water.

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N-Substituted calothrixin B derivatives inhibited the proliferation of HL-60 promyelocytic leukemia cells

Cited by 40 publications

References 19 publications

Bioactive Compounds Isolated from Microalgae in Chronic Inflammation and Cancer

Bioactive Compounds Isolated from Microalgae in Chronic Inflammation and Cancer

Cyanobacteria as Natural Therapeutics and Pharmaceutical Potential: Role in Antitumor Activity and as Nanovectors

Degradation and inactivation efficacy of ozone water for antineoplastic drugs in hospital settings

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