[N‐methyl‐11C]MeAIB, a tracer for system A amino acid transport: preparation from [11C]methyl triflate and HPLC metabolite analysis of plasma samples after intravenous administration in man

Relationship between [ 14 C]MeAIB uptake and amino acid transporter family gene expression levels or proliferative activity in a pilot study in human carcinoma cells: Comparison with [ 3 H]methionine uptake

“…Stability studies have shown that more than 95% of [ 11 C]MeAIB remained unchanged in human plasma 30 minutes after administration. Since it is an unnatural amino acid, it also cannot be used for protein synthesis [17]. Therefore, [ 11 C]MeAIB imaging may more accurately represent the uptake of amino acid transporter system A compared to [ 11 C]MET.…”

“…Compared with [ 11 C]MET, [ 11 C]MeAIB is metabolically stable [17] and it has been studied both pre-clinically and clinically. For example, [ 11 C]MeAIB has been shown to be useful in the measurement of amino acid uptake into skeletal muscle and in the diagnosis of malignant lymphoma and head and neck cancers [18][19][20].…”

Relationship between [ 14 C]MeAIB uptake and amino acid transporter family gene expression levels or proliferative activity in a pilot study in human carcinoma cells: Comparison with [ 3 H]methionine uptake

“…Stability studies have shown that more than 95% of [ 11 C]MeAIB remained unchanged in human plasma 30 minutes after administration. Since it is an unnatural amino acid, it also cannot be used for protein synthesis [17]. Therefore, [ 11 C]MeAIB imaging may more accurately represent the uptake of amino acid transporter system A compared to [ 11 C]MET.…”

“…Compared with [ 11 C]MET, [ 11 C]MeAIB is metabolically stable [17] and it has been studied both pre-clinically and clinically. For example, [ 11 C]MeAIB has been shown to be useful in the measurement of amino acid uptake into skeletal muscle and in the diagnosis of malignant lymphoma and head and neck cancers [18][19][20].…”

Good manufacturing practice production of the system A amino acid transport tracer [11C]MeAIB on a commercial synthesis module

“…Production of [ 11 C]methyl triflate ([ 11 C]MeOTf) on the GE Tracerlab FX C Pro was performed with manufacturer's specified chemicals. The labeling precursor, α ‐amino‐isobutyric acid methyl ester hydrochloride, was prepared according to Någren et al . and was crystallized from 100% sterile ethanol.…”

Synthesis of N-alkyl-Cα,α-dimethylglycine derivatives

“…24 Me-Aib has been labelled with carbon-11 for PET studies on System A amino acid transport in vivo, and 11 CMe-Aib has been shown to be metabolically stable in humans. 25 Me-Aib has also been reported to reduce hepatic collagen content of rats in a model of CCl 4 -induced liver injury, and in vitro studies indicated that Me-Aib directly reduced collagen synthesis. 26 Due to the interest in biological applications of Me-Aib a few methods for their synthesis have been reported.…”

Relationship between [ 14 C]MeAIB uptake and amino acid transporter family gene expression levels or proliferative activity in a pilot study in human carcinoma cells: Comparison with [ 3 H]methionine uptake

“…Stability studies have shown that more than 95% of [ 11 C]MeAIB remained unchanged in human plasma 30 minutes after administration. Since it is an unnatural amino acid, it also cannot be used for protein synthesis [17]. Therefore, [ 11 C]MeAIB imaging may more accurately represent the uptake of amino acid transporter system A compared to [ 11 C]MET.…”

“…Compared with [ 11 C]MET, [ 11 C]MeAIB is metabolically stable [17] and it has been studied both pre-clinically and clinically. For example, [ 11 C]MeAIB has been shown to be useful in the measurement of amino acid uptake into skeletal muscle and in the diagnosis of malignant lymphoma and head and neck cancers [18][19][20].…”

Good manufacturing practice production of the system A amino acid transport tracer [11C]MeAIB on a commercial synthesis module

“…Production of [ 11 C]methyl triflate ([ 11 C]MeOTf) on the GE Tracerlab FX C Pro was performed with manufacturer's specified chemicals. The labeling precursor, α ‐amino‐isobutyric acid methyl ester hydrochloride, was prepared according to Någren et al . and was crystallized from 100% sterile ethanol.…”

Synthesis of N-alkyl-Cα,α-dimethylglycine derivatives

“…24 Me-Aib has been labelled with carbon-11 for PET studies on System A amino acid transport in vivo, and 11 CMe-Aib has been shown to be metabolically stable in humans. 25 Me-Aib has also been reported to reduce hepatic collagen content of rats in a model of CCl 4 -induced liver injury, and in vitro studies indicated that Me-Aib directly reduced collagen synthesis. 26 Due to the interest in biological applications of Me-Aib a few methods for their synthesis have been reported.…”

Relationship between [ 14 C]MeAIB uptake and amino acid transporter family gene expression levels or proliferative activity in a pilot study in human carcinoma cells: Comparison with [ 3 H]methionine uptake

“…Stability studies have shown that more than 95% of [ 11 C]MeAIB remained unchanged in human plasma 30 minutes after administration. Since it is an unnatural amino acid, it also cannot be used for protein synthesis [17]. Therefore, [ 11 C]MeAIB imaging may more accurately represent the uptake of amino acid transporter system A compared to [ 11 C]MET.…”

“…Compared with [ 11 C]MET, [ 11 C]MeAIB is metabolically stable [17] and it has been studied both pre-clinically and clinically. For example, [ 11 C]MeAIB has been shown to be useful in the measurement of amino acid uptake into skeletal muscle and in the diagnosis of malignant lymphoma and head and neck cancers [18][19][20].…”

Good manufacturing practice production of the system A amino acid transport tracer [11C]MeAIB on a commercial synthesis module

“…Production of [ 11 C]methyl triflate ([ 11 C]MeOTf) on the GE Tracerlab FX C Pro was performed with manufacturer's specified chemicals. The labeling precursor, α ‐amino‐isobutyric acid methyl ester hydrochloride, was prepared according to Någren et al . and was crystallized from 100% sterile ethanol.…”

Synthesis of N-alkyl-Cα,α-dimethylglycine derivatives

“…24 Me-Aib has been labelled with carbon-11 for PET studies on System A amino acid transport in vivo, and 11 CMe-Aib has been shown to be metabolically stable in humans. 25 Me-Aib has also been reported to reduce hepatic collagen content of rats in a model of CCl 4 -induced liver injury, and in vitro studies indicated that Me-Aib directly reduced collagen synthesis. 26 Due to the interest in biological applications of Me-Aib a few methods for their synthesis have been reported.…”