N-acetylcysteine possesses antidepressant-like activity through reduction of oxidative stress: Behavioral and biochemical analyses in rats

Smaga, Irena; Pomierny, Bartosz; Krzyżanowska, Weronika; Pomierny-Chamioło, Lucyna; Miszkiel, Joanna; Niedzielska, Ewa; Ogorka, Agata Zofia Tabis; Filip, Małgorzata

doi:10.1016/j.pnpbp.2012.06.018

Cited by 73 publications

(66 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Though specific trials for antidepressant effects in depression are still lacking, NAC shows antidepressant-like activity in several preclinical models; studies corroborate the antidepressant-like effects of NAC in rats subjected to the forced swimming test (Ferreira et al 2008) and in mice subjected to the tail suspension test (Linck et al 2012). Additionally, the chronic administration of NAC resulted in a dose-dependent reduction in immobility time in bulbectomized rats and resulted in a significant increase in cellular antioxidant mechanisms (superoxide dismutase activity) in the frontal cortex, hippocampus, and striatum (Smaga et al 2012). Arent and colleagues (2012) demonstrated that NAC and DFX, alone or in combination, reversed the stressinduced sweet food consumption decrease and oxidative stress in rats submitted to chronic mild stress.…”

Section: Discussionmentioning

confidence: 78%

Behavioral Responses in Rats Submitted to Chronic Administration of Branched-Chain Amino Acids

et al. 2013

View full text Add to dashboard Cite

Maple syrup urine disease (MSUD) is an inborn metabolism error caused by a deficiency of branched-chain a-keto acid dehydrogenase complex activity. This blockage leads to an accumulation of the branched-chain amino acids (BCAA) leucine, isoleucine, and valine, as well as their corresponding a-keto and a-hydroxy acids. Previous reports suggest that MSUD patients are at high risk for chronic neuropsychiatric problems. Therefore, in this study, we assessed variables that suggest depressive-like symptoms (anhedonia as measured by sucrose intake, immobility during the forced swimming test and body and adrenal gland weight) in rats submitted to chronic administration of BCAA during development. Furthermore, we determined if these parameters were sensitive to imipramine and N-acetylcysteine/deferoxamine (NAC/DFX). Our results demonstrated that animals subjected to chronic administration of branched-chain amino acids showed a decrease in sucrose intake without significant changes in body weight. We also observed an increase in adrenal gland weight and immobility time during the forced swimming test. However, treatment with imipramine and NAC/DFX reversed these changes in the behavioral tasks. In conclusion, this study demonstrates a link between MSUD and depression in rats. Moreover, this investigation reveals that the antidepressant action of NAC/DFX and imipramine might be associated with their capability to maintain pro-/anti-oxidative homeostasis.

show abstract

Section: Discussionmentioning

confidence: 78%

Behavioral Responses in Rats Submitted to Chronic Administration of Branched-Chain Amino Acids

et al. 2013

View full text Add to dashboard Cite

show abstract

“…As for the enzymes, the activity of GSH-Px [45,46,[54][55][56][57], GSH-R [44,52] and GSH-S-transferase [52] was found to be decreased. A reduction of the TAC was seen in the cerebellum and nucleus accumbens in the bulbectomized rats, while an increase of this parameter was observed in the prefrontal cortex [61]. Lowered SOD activity was seen in several animal models [40,41,44,[47][48][49]51,52,[54][55][56][57]61,62], and its down-regulation seemed to be a general mechanism caused by exposure to chronic stress (see also [58,60]).…”

Section: Animal Studiesmentioning

confidence: 99%

“…A reduction of the TAC was seen in the cerebellum and nucleus accumbens in the bulbectomized rats, while an increase of this parameter was observed in the prefrontal cortex [61]. Lowered SOD activity was seen in several animal models [40,41,44,[47][48][49]51,52,[54][55][56][57]61,62], and its down-regulation seemed to be a general mechanism caused by exposure to chronic stress (see also [58,60]). The CAT activity either decreased following sleep deprivation [41,48,49,[51][52][53]62] or increased [40,58] (Table 1).…”

Section: Animal Studiesmentioning

confidence: 99%

Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism

Smaga

Niedzielska

Gawlik

et al. 2015

Pharmacological Reports

Self Cite

221

123

View full text Add to dashboard Cite

The pathophysiology of psychiatric diseases, including depression, anxiety, schizophrenia and autism, is far from being fully elucidated. In recent years, a potential role of the oxidative stress has been highlighted in the pathogenesis of neuropsychiatric disorders. A body of clinical and preclinical evidence indicates that psychiatric diseases are characterized by higher levels of oxidative biomarkers and with lower levels of antioxidant defense biomarkers in the brain and peripheral tissues. In this article, we review current knowledge on the role of the oxidative stress in psychiatric diseases, based on clinical trials and animal studies, in addition, we analyze the effects of drug-induced modulation of oxidative balance and explore pharmacotherapeutic strategies for oxidative stress reduction.

show abstract

“…NAC is a glutathione precursor that has been shown to be involved in oxidative homeostasis, dopamine modulations and to interact with several inflammatory markers [80]. Preclinical studies with these agents have yielded promising results so far, with evidence supporting an antidepressant-like effect in animal studies [81,82,83,84,85]. …”

Section: The Future Of Research On Inflammation In Mddmentioning

confidence: 99%

Targeting the Inflammatory Pathway as a Therapeutic Tool for Major Depression

Noto¹,

Rizzo²,

Mansur³

et al. 2014

Neuroimmunomodulation

View full text Add to dashboard Cite

In the last decades convergent findings from several lines of evidence has revealed a robust association between major depressive disorder (MDD) and inflammatory pathways. Despite this, the translation of these findings into new and better treatments for MDD has not occurred. The objective of this study is to comprehensively review what is already known with reasonable certainty on inflammatory pathways in MDD, to clarify some points that have been insufficiently studied and to discuss the implications of these findings for future studies targeting inflammatory pathways as a therapeutic tool for individuals with MDD.

show abstract

N-acetylcysteine possesses antidepressant-like activity through reduction of oxidative stress: Behavioral and biochemical analyses in rats

Cited by 73 publications

References 49 publications

Behavioral Responses in Rats Submitted to Chronic Administration of Branched-Chain Amino Acids

Behavioral Responses in Rats Submitted to Chronic Administration of Branched-Chain Amino Acids

Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism

Targeting the Inflammatory Pathway as a Therapeutic Tool for Major Depression

Contact Info

Product

Resources

About