volume 90, issue 4, P743-750 2011
DOI: 10.1002/jnr.22819
View full text
Anthony Falluel-Morel, Lulu Lin, Katie Sokolowski, Elizabeth McCandlish, Brian Buckley, Emanuel DiCicco-Bloom

Abstract: Mercury is an environmental toxicant that can disrupt brain development. However, while progress has been made in defining its neurotoxic effects, we know far less about available therapies that can effectively protect brain in exposed individuals. We previously developed an animal model in which we defined the sequence of events underlying neurotoxicity: Methylmercury (MeHg) injection in postnatal rat acutely induced inhibition of mitosis and stimulated apoptosis in the hippocampus, that later resulted in in…

expand abstract