N-3 PUFAs and their specialized pro-resolving lipid mediators on airway inflammatory response: beneficial effects in the prevention and treatment of respiratory diseases

Abstract

Respiratory diseases include a wide range of pathologies with different clinical manifestations, affecting the normal airways and lung function. An increase in the inflammatory response is considered a characteristic hallmark...

Eicosapentaenoic acid-enriched phospholipids alleviate glucose and lipid metabolism in spontaneously hypertensive rats with CD36 mutation: a precise nutrition strategy

“…Interestingly, EPA and its lipid mediators are known to have an inflammation pro-resolution effect. 33…”

The Role of Omega-3 Polyunsaturated Fatty Acids and Their Lipid Mediators on Skeletal Muscle Regeneration: A Narrative Review

“…There is emerging evidence that bioactive lipids derived from n-3 and n-6 PUFAs play a key role in the initiation and resolution of the inflammatory response [ 12 , 43 ]. After a muscle injury, n-3 and n-6 PUFAs are rapidly released from immune cell membrane phospholipids via phospholipase enzymes and metabolized via enzymatic reactions to the lipid mediators oxylipins and endocannabinoids [ 44 ].…”

“…Oxylipins with anti-inflammatory and proresolving activities are mostly derived from EPA and DHA, including the resolvins (Rv) from EPA (E series) and DHA (D series) and the DHA-derived maresins (Ma) and protectins (Pr), collectively termed “specialized pro-resolving mediators” (SPMs). AA-derived lipoxins also contribute to this group [ 43 ].…”

Mechanistic study of salidroside on ovalbumin-induced asthmatic model mice based on untargeted metabolomics analysis

“…Some lipid mediators such as n-3 polyunsaturated fatty acids (n-3 PUFAs) and eicosapentaenoic acid (EPA) have been reported to have significant ameliorative effects on asthma by reducing airway inflammation. 5 Embelin could alleviate airway inflammation in asthmatic model rats by suppressing the T helper cell (Th2)-mediated response. 6 Safranal alleviated the ovalbumin (OVA)-induced airway inflammatory response in asthmatic mice by inhibiting mast cell activation.…”