n–3 polyunsaturated fatty acids supplementation decreases asymmetric dimethyl arginine and arachidonate accumulation in aging spontaneously hypertensive rats

Raimondi, Laura; Lodovici, Maura; Visioli, Francesco; Sartiani, Laura; Cioni, L.; Alfarano, Chiara; Banchelli, G.; Pirisino, R.; Cecchi, Emanuele; Cerbai, Elisabetta; Mugelli, Alessandro

doi:10.1007/s00394-004-0528-5

Cited by 22 publications

(17 citation statements)

References 33 publications

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“…21 It is possible that EPA's ADMA reduction effect may have been particularly emphasized in our study, because each of the subject patients had backgrounds of cerebral infarction, many of which were accompanied by hypertension and DM. Moreover, in the study in which EPA was administered to spontaneously hypertensive rats, the reduction in the level of ADMA was greater in the EPA-administered group than it was in the group that was administered olive oil, 22 supporting the fact that EPA reduces ADMA.…”

Section: Discussionmentioning

confidence: 92%

Effects of Eicosapentaenoic Acid on Asymmetric Dimethylarginine in Patients in the Chronic Phase of Cerebral Infarction: A Preliminary Study

Hagiwara

Nishiyama

Katayama

2011

Journal of Stroke and Cerebrovascular Diseases

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Section: Discussionmentioning

confidence: 92%

Effects of Eicosapentaenoic Acid on Asymmetric Dimethylarginine in Patients in the Chronic Phase of Cerebral Infarction: A Preliminary Study

Hagiwara

Nishiyama

Katayama

2011

Journal of Stroke and Cerebrovascular Diseases

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“…Plasma levels of ADMA are significantly higher in SHRs at 4 weeks (prehypertensive stage), 12 weeks (hypertensive stage), and 24 weeks (hypertensive endorgan damage stage) [34] . A significantly higher concentration of plasma ADMA also exists in aging (16-month-old) male SHRs [38] . These findings indicate that a reduced NO bioavailability is associated with hypertension and end-organ damage [36] and that ADMA is a risk factor for ED [38] .…”

Section: Similar Pathogenesis Of Ed and Asymmetric Dimethylarginine Imentioning

confidence: 97%

“…A significantly higher concentration of plasma ADMA also exists in aging (16-month-old) male SHRs [38] . These findings indicate that a reduced NO bioavailability is associated with hypertension and end-organ damage [36] and that ADMA is a risk factor for ED [38] . The information obtained from SHRs suggests a low bioavailability of NO and impairment of the L -arginine-NO pathway in humans [23] .…”

Section: Similar Pathogenesis Of Ed and Asymmetric Dimethylarginine Imentioning

confidence: 97%

Aging Male Spontaneously Hypertensive Rat as an Animal Model for the Evaluation of the Interplay between Contrast-Induced Acute Kidney Injury and Cardiorenal Syndrome in Humans

Zhang

Fallahzadeh

McCullough³

2016

Cardiorenal Med

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Background:Although there are some animal models for biomarkers of contrast-induced acute kidney injury (CI-AKI), for cardiorenal syndrome (CRS) and for acute renal failure, the interplay between CI-AKI and CRS has yet to be evaluated. Insight into the pathogenesis of CRS is urgently needed from animal models in order to foster the discovery and implementation of novel biomarkers for this disease. Specially designed animal models for type 1 and 3 CRS, particularly CI-AKI, have not yet emerged. Summary: We hypothesize that the aging male spontaneously hypertensive rat (SHR) is likely to be a suitable model. The SHR model is able to mimic risk factors for preclinical CRS that appears in the clinical setting, specifically hypertension, age, preexisting damage and dysfunction of the heart and kidney, endothelial dysfunction, increased level of reactive oxygen species, decreased level and bioavailability of nitric oxide (NO), impairment of the L -arginine-NO pathway, and insulin resistance. In the SHR, CI-AKI results in a different profile of AKI biomarkers than is seen with preexisting chronic kidney injury. Key Messages: The SHR model can be used to evaluate the interaction between CI-AKI and CRS type 1 and 3 and to verify neutrophil gelatinase-associated lipocalin (NGAL) as a reliable CI-AKI biomarker for clinical application. Further research is warranted with a large number of aging male SHRs to prove NGAL as a sensitive, specific, highly predictive, early biomarker for CI-AKI.

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“…24) It has been well reported that a 20:4n-6 decline would be caused by 22:6n-3 administration in vivo. [25][26][27][28] In the present study, the hepatic 20:4n-6 decline in newborn rats resulted from indirect diet intervention by supplementing the experimental diets fed to the dams. The D6D mRNA expression level showed that D6D was significantly low in the newborn pups fed by the dams that had received the DHA diet, which may account for the decline of 20:4n-6 in the newborn liver.…”

Section: Discussionmentioning

confidence: 99%

The Metabolism and Distribution of Docosapentaenoic Acid (n-6) in the Liver and Testis of Growing Rats

Tam

Sawada²,

Yan

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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To investigate the metabolism and distribution of docosapentaenoic acid (22:5n-6, DPA) in the liver and testis of growing rats, 22:5n-6 was administered to their dams. Newborn rats with a low hepatic arachidonic acid (20:4n-6, AA) level were generated by administrating a diet rich in docosahexaenoic acid (22:6n-3, DHA) but n-6 fatty acid (FA) free to pregnant dams. After parturition, 22:5n-6 or linoleic acid (18:2n-6, LA) was administered with a high level of 22:6n-3 to the dams until weaning. At weaning, the hepatic 20:4n-6 level was significantly highest in the DPA-DHA but not LA-DHA diet-fed animals. The hepatic delta-6 desaturase (D6D) mRNA abundance was significantly lower in both the LA-DHA and DPA-DHA diet-fed animals, connoted with the 20:4n-6 content recovered by 22:5n-6 that did not involve D6D and supporting the occurrence of retroconversion in the liver of the growing rats. The low D6D level in the 3-week-old testis was not in proportion to the elevated 22:5n-6 level, implying that early testicular 22:5n-6 accumulation might require supply from the circulation system.

show abstract

n–3 polyunsaturated fatty acids supplementation decreases asymmetric dimethyl arginine and arachidonate accumulation in aging spontaneously hypertensive rats

Cited by 22 publications

References 33 publications

Effects of Eicosapentaenoic Acid on Asymmetric Dimethylarginine in Patients in the Chronic Phase of Cerebral Infarction: A Preliminary Study

Effects of Eicosapentaenoic Acid on Asymmetric Dimethylarginine in Patients in the Chronic Phase of Cerebral Infarction: A Preliminary Study

Aging Male Spontaneously Hypertensive Rat as an Animal Model for the Evaluation of the Interplay between Contrast-Induced Acute Kidney Injury and Cardiorenal Syndrome in Humans

The Metabolism and Distribution of Docosapentaenoic Acid (n-6) in the Liver and Testis of Growing Rats

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