Myrciaria Glazioviana Leaves Anti-Inflammatory Antinociceptive And Hepatoprotection Potential and Chemical Profile by Mass Spectrometry

Abstract

Plants represent an ancient source of medicines for humanity and an important source of active substances. Myrciaria glazioviana belongs to Myrtaceae family with antibacterial and antifungal activities describled. The objective of this study is to evaluate the anti-inflammatory and antinociceptive activity of the dichloromethane extract of the leaves of M. glazioviana through in vivo models (Carrageenan-induced paw edema model and abdominal constriction test induced by acetic acid, respectively) and to identify compunds present in the crude extract by mass spectrometry. Histopathological analyzes of the animal samples used in the studies were also performed. It was possible to observe the presence of antinociceptive, antiinflammatory and hepatoprotective activities in M. glazioviana extract, as well as the presence of phenols and flavonoids in its composition and Gallic acid and Quinic acid were identified.