Myope CNV

Voykov, Bogomil; Ziemssen, Focke

doi:10.1055/s-0031-1281583

Cited by 5 publications

(3 citation statements)

References 22 publications

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“…1 Many fundus diseases can lead to the formation of CNV, of which age-related macular degeneration (AMD) and pathological myopia (PM) are the two main causes. 2,3 At present, intravitreal injection of anti-vascular endothelial growth factor (VEGF) drugs has become an important way to treat CNV. 4 These drugs can inhibit the growth of CNV by binding and blocking VEGF receptors, reducing vascular permeability and the fluid area below the RPE layer.…”

Section: Introductionmentioning

confidence: 99%

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Morphological prognosis prediction of choroid neovascularization from longitudinal SD‐OCT images

et al. 2023

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BackgroundChoroid neovascularization (CNV) has no obvious symptoms in the early stage, but with its gradual expansion, leakage, rupture, and bleeding, it can cause vision loss and central scotoma. In some severe cases, it will lead to permanent visual impairment.PurposeAccurate prediction of disease progression can greatly help ophthalmologists to formulate appropriate treatment plans and prevent further deterioration of the disease. Therefore, we aim to predict the growth trend of CNV to help the attending physician judge the effectiveness of treatment.MethodsIn this paper, we develop a CNN‐based method for CNV growth prediction. To achieve this, we first design a registration network to rigidly register the spectral domain optical coherence tomography (SD‐OCT) B‐scans of each subject at different time points to eliminate retinal displacements of longitudinal data. Then, considering the correlation of longitudinal data, we propose a co‐segmentation network with a correlation attention guidance (CAG) module to cooperatively segment CNV lesions of a group of follow‐up images and use them as input for growth prediction. Finally, based on the above registration and segmentation networks, an encoder‐recurrent‐decoder framework is developed for CNV growth prediction, in which an attention‐based gated recurrent unit (AGRU) is embedded as the recurrent neural network to recurrently learn robust representations.ResultsThe registration network rigidly registers the follow‐up images of patients to the reference images with a root mean square error (RMSE) of 6.754 pixels. And compared with other state‐of‐the‐art segmentation methods, the proposed segmentation network achieves high performance with the Dice similarity coefficients (Dsc) of 85.27%. Based on the above experiments, the proposed growth prediction network can play a role in predicting the future CNV morphology, and the predicted CNV has a Dsc of 83.69% with the ground truth, which is significantly consistent with the actual follow‐up visit.ConclusionThe proposed registration and segmentation networks provide the possibility for growth prediction. In addition, accurately predicting the growth of CNV enables us to know the efficacy of the drug against individuals in advance, creating opportunities for formulating appropriate treatment plans.

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Section: Introductionmentioning

confidence: 99%

“…With the expansion or leakage of CNV, retinal pigment epithelium (RPE) layer detachment, and vitreous or retinal hemorrhage will be caused, resulting in serious visual loss 1 . Many fundus diseases can lead to the formation of CNV, of which age‐related macular degeneration (AMD) and pathological myopia (PM) are the two main causes 2,3 …”

Section: Introductionmentioning

confidence: 99%

Morphological prognosis prediction of choroid neovascularization from longitudinal SD‐OCT images

et al. 2023

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“…The term PM is applied if additional characteristic morphological signs are visible on funduscopy that may be associated with visual impairment [7, 8]. Particularly myopic choroidal neovascularization (mCNV) constitutes a high risk for visual loss [9-11]. As a result, quality of life and ability to work may be impaired.…”

Section: Introductionmentioning

confidence: 99%

Design and Baseline Characteristics of the HELP Study: An Extended and Long-Term Observation of Pathological Myopia in Caucasians

et al. 2018

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Purpose: To assess the natural disease progression of high myopia in Caucasians considered at risk for the development of myopic choroidal neovascularization (mCNV). Methods: Subjects were recruited in 25 clinical sites between June 2014 and June 2016. Main inclusion criteria included axial length of ≥26 mm, best-corrected visual acuity ≥0.05 decimal equivalent and presence of at least one out of five predefined morphological disease risk criteria. These were (1) subfoveal choroidal thinning < 50 µm, (2) enhanced choroidal curvature length > 6,300 µm, (3) lacquer cracks, (4) patchy atrophy > 5 mm² and (5) preexisting mCNV in the fellow eye (German Clinical Trial Register DRKS00007761). Results: A total of 150 participants (66% females) with a mean age of 57.2 (±12.7) years (range 21.9–86.2 years) were included. The disease criteria most frequently encountered were choroidal thinning (33.3%) and lacquer cracks (32.7%). Enhanced choroidal curvature length was detected in only 8 subjects and always occurred in combination with other disease criteria. Presence of patchy atrophy was found to be more common in older subjects (p = 0.0012) and also associated with a more severe disease manifestation. Conclusion: The baseline data of this study indicate that enhanced choroidal curvature might be less common in Caucasians than in Asian populations. Further, disease severity in patients with high myopia is relatively high in the presence of patchy atrophy.

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Morphologische Charakteristika der myopen choroidalen Neovaskularisation

Inhoffen

Ziemssen

2012

Ophthalmologe

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Choroidal neovascularization due to pathological myopia (mCNV) differs in important characteristics from lesions seen in age-related macular degeneration (ARMD). Myopic CNV is associated with typical phenomena, such as lacquer cracks or patchy atrophy drusen or pigment epithelium detachment are rare occurrences. The dimensions of mCNV and the extent of leakage are substantially smaller. The heterogeneous combination of thinning and concomitant staphyloma often complicates the early detection of neovascular lesions. Diagnosis and evaluation of the clinical progress are only possible using the combination of different imaging modalities, e.g. funduscopy, fluorescein angiography (FLA) and spectral domain optical coherence tomography (SD-OCT). Special forms, such as periconal mCNV or dome-shaped variants exhibit a typical progression and response to therapy. In the course of the disease a progressive pigmentation and secondary atrophy occur and later, depigmentation of the mCNV complicates the demarcation of the original mCNV within the zone of atrophy. Extensive information and counselling seem to be mandatory in order to allow a better self-assessment. Sometimes, patients notice the first symptoms of recurrent mCNV activity before confirmation is possible by objective diagnostics.

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Myope CNV

Cited by 5 publications

References 22 publications

Morphological prognosis prediction of choroid neovascularization from longitudinal SD‐OCT images

Morphological prognosis prediction of choroid neovascularization from longitudinal SD‐OCT images

Design and Baseline Characteristics of the HELP Study: An Extended and Long-Term Observation of Pathological Myopia in Caucasians

Morphologische Charakteristika der myopen choroidalen Neovaskularisation

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