Myoinositol: Does It Improve Sperm Mitochondrial Function and Sperm Motility?

Condorelli, Rosita A.; Vignera, Sandro La; Bellanca, Salvatore; Vicari, Enzo; Calogero, Aldo E.

doi:10.1016/j.urology.2012.03.005

Cited by 113 publications

(100 citation statements)

References 21 publications

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“…Interestingly, recent data suggest that the sperm motility of patients with abnormal sperm parameters can be enhanced by incubation with myoinositol, and this seems to be paralleled by an increase in the proportion of sperm with high MMP (Condorelli et al 2012).…”

Section: Mitochondrial Functionality and Sperm Qualitymentioning

confidence: 99%

Mitochondria functionality and sperm quality

Amaral¹,

Lourenço²,

Marques³

et al. 2013

Reproduction

433

332

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Although mitochondria are best known for being the eukaryotic cell powerhouses, these organelles participate in various cellular functions besides ATP production, such as calcium homoeostasis, generation of reactive oxygen species (ROS), the intrinsic apoptotic pathway and steroid hormone biosynthesis. The aim of this review was to discuss the putative roles of mitochondria in mammalian sperm function and how they may relate to sperm quality and fertilisation ability, particularly in humans. Although paternal mitochondria are degraded inside the zygote, sperm mitochondrial functionality seems to be critical for fertilisation. Indeed, changes in mitochondrial integrity/functionality, namely defects in mitochondrial ultrastructure or in the mitochondrial genome, transcriptome or proteome, as well as low mitochondrial membrane potential or altered oxygen consumption, have been correlated with loss of sperm function (particularly with decreased motility). Results from genetically engineered mouse models also confirmed this trend. On the other hand, increasing evidence suggests that mitochondria derived ATP is not crucial for sperm motility and that glycolysis may be the main ATP supplier for this particular aspect of sperm function. However, there are contradictory data in the literature regarding sperm bioenergetics. The relevance of sperm mitochondria may thus be associated with their role in other physiological features, particularly with the production of ROS, which in controlled levels are needed for proper sperm function. Sperm mitochondria may also serve as intracellular Ca 2C stores, although their role in signalling is still unclear.

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Section: Mitochondrial Functionality and Sperm Qualitymentioning

confidence: 99%

Mitochondria functionality and sperm quality

Amaral¹,

Lourenço²,

Marques³

et al. 2013

Reproduction

433

332

View full text Add to dashboard Cite

show abstract

“…In conclusion, myoinositol plays a key role in the male reproductive system by regulating the osmolality of the seminal plasma, as well as sperm motility and acrosome reaction (Condorelli et al 2011). Condorelli et al (2012) suggested that myoinositol significantly increased the percentage of spermatozoa with progressive motility based on 2 h incubation of human spermatozoa with 2 mg mL À1 myoinositol. The increase in progressive motility of spermatozoa was associated with a significant increase in the percentage of spermatozoa with high mitochondrial membrane potential.…”

Section: Biological Functions and Canonical And Metabolic Pathways Ofmentioning

confidence: 99%

Implication of transcriptome profiling of spermatozoa for stallion fertility

Suliman

Becker

Wimmers

2018

Reprod. Fertil. Dev.

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Abstract. Poor fertility of breeding stallions is a recognised problem in the equine industry. The aim of the present study was to detect molecular pathways using two groups of stallions that differed in pregnancy rates as well as in the proportion of normal and motile spermatozoa. RNA was isolated from spermatozoa of each stallion and microarray data were analysed to obtain a list of genes for which transcript abundance differed between the groups (P #0.05, fold change $1.2). In all, there were 437 differentially expressed (DE) genes between the two groups (P # 0.05, fold change $1.2). Next, the DE genes were analysed using Database for Annotation, Visualisation, and Integrated Discovery (DAVID). Finally, ingenuity pathways analysis (IPA) was used to identify top biological functions and significant canonical pathways associated with the DE genes. Analysis using the DAVID database showed significant enrichment in the gene ontology (GO) term 'RNA binding' (P ¼ 0.05) and in the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway cytokinecytokine receptor interaction (P ¼ 0.02). Furthermore, IPA analysis showed interconnected biological functions and canonical pathways involved in the regulation of spermatogenesis and male fertility. In addition, significantly enriched metabolic pathways were identified. In conclusion, the present study has identified, for the first time, molecular processes in stallion spermatozoa that could be associated with stallion fertility.

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“…Furthermore spermatozoa with high MMP are directly linked to fertilization rate, in vivo and in vitro (7). However, the effects of MYO-Ins on phosphatidylserine (PS) externalization, an early marker of apoptosis, on chromatin compactness and on DNA fragmentation, in normozoospermic and OAT patients, were not known (4,8). Low sperm motility is a primary cause of male infertility,…”

mentioning

confidence: 99%

Analysis of MYO-Inositol effect on spermatozoa motility, in hyper viscous ejaculates and in patients with grades II and III varicocele

Scarselli

Lobascio

Terribile

et al. 2016

Arch Ital Urol Androl

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The goal of this study is to evaluate MYOInositol effects on spermatozoa motility, in patients’ ejaculates with severe varicocele or hyper viscosity. The study included normal viscosity ejaculate from 30 patients affected by varicocele and hyper viscosity ejaculate from 33 patients without any testicular pathologies. All selected samples showed sperm concentration > 2 million/ml and progressive motility < 32%. In both groups, the pellet obtained after centrifugation in buffered medium, was divided in two aliquots, both incubated for 15 minutes at 37°C: one with MYO-Inositol and the other one, as control, only in phosphate buffered saline (PBS). Afterwards, the sperm progressive motility was assessed using Computer Assisted Sperm Analysis (CASA system). Incubation with MYO-Inositol improved sperm progressive motility in high viscosity samples compared to control group (38.9% ± 3.0 vs 24.35% ± 2.41, respectively; p ≤ 0.0001). Conversely, no statistically significant difference was observed in total sperm progressive motility in varicocele samples compared with control group (22.7% ± 2.07 vs 26.7% ± 3.31, respectively; p = 0.085). The MYO-Inositol positive effect on spermatozoa motility may depend on the type of sperm damage: heavy structural and biochemical defects which typically affects patients with varicocele are not restored by Inositol. On the contrary, MYOInositol is able to improve sperm motility in semen samples with high viscosity, since those samples show no substantial structural sperm defects.

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Myoinositol: Does It Improve Sperm Mitochondrial Function and Sperm Motility?

Cited by 113 publications

References 21 publications

Mitochondria functionality and sperm quality

Mitochondria functionality and sperm quality

Implication of transcriptome profiling of spermatozoa for stallion fertility

Analysis of MYO-Inositol effect on spermatozoa motility, in hyper viscous ejaculates and in patients with grades II and III varicocele

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