Myoglobinuric Renal Failure due to Drug-induced Rhabdomyolysis

Abstract

<jats:p> 1 Two cases of drug-induced rhabdomyolysis, one of them presenting with acute myoglobinuric renal failure are described. </jats:p><jats:p> 2 The pathogenesis of rhabdomyolysis and renal failure in our cases is discussed with reference to work published by other authors. </jats:p><jats:p> 3 Whereas there seems to be obvious evidence for direct toxic drug-muscle interaction, the mechanism for the development of myoglobinuric renal failure remains unclear. </jats:p>

Comparison of lactated Ringer's solution and 0.9% saline in the treatment of rhabdomyolysis induced by doxylamine intoxication

“…Rhabdomyolysis induced by doxylamine overdose was first reported in 1983, 2 and Koppel et al 3 described complications including rhabdomyolysis in 1987. It has been reported that the incidence of rhabdomyolysis induced by doxylamine overdose was 5-57%, and that rhabdomyolysis can progress to acute renal failure.…”

Diphenhydramine and Dimenhydrinate Poisoning: an Evidence-Based Consensus Guideline for Out-of-Hospital Management

“…Anticholinergic symptoms present in these cases included tachycardia, mydriasis, and dry skin and mucous membranes. Anticholinergic symptoms were not reported in the case by Hampel et al (71). The dose ingested in the case reported by Viertel et al (66) was 1500 mg; the amounts ingested in the remaining cases were not reported.…”

“…The temperatures on admission were documented in three of the other four cases and were reported to be 37.6, 37.1, and 37.2°C) (31,56). Four of the five cases were adults (50,56,71) and one was a 23-month-old (31). Anticholinergic symptoms present in these cases included tachycardia, mydriasis, and dry skin and mucous membranes.…”

“…In the case published by Frankel et al (70), ingestion of doxylamine could not be excluded. In five cases, other causes for rhabdomyolysis were absent (e.g., lack of seizures, severe agitation, severe electrolyte disturbances or acidosis, or the use of physical restraints) (31,50,56,71). In the case reported by Emadian et al (50), the patient's temperature on admission was 39.1°C.…”

Rhabdomyolysis following Status asthmaticus

“…Although it is usually seen in alcohol abusers, seizures, and/or crush injuries [2], the syndrome has rarely been reported following status asth maticus. Some drugs, such as theophylline [3][4][5][6], cortico steroid [7][8][9][10], and other drugs [11] induce skeletal mus cle injury. We report here a case of rhabdomyolysis fol lowing status asthmaticus.…”