Myofibroblasts in the stroma of oral squamous cell carcinoma are associated with poor prognosis

Kellermann, Michele Gassen; Sobral, Lays Martin; Silva, S. D. Da; Zecchin, Karina G.; Graner, Edgard; Lopes, Márcio Ajudarte; Nishimoto, Inês Nobuko; Kowalski, Luiz Paulo; Coletta, Ricardo D.

doi:10.1111/j.1365-2559.2007.02873.x

Cited by 112 publications

(186 citation statements)

References 7 publications

(18 reference statements)

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“…In studies that evaluated the transdifferentiation of fibroblasts to myofibroblasts in OSCC (19,20,21,22) , in two of them, the non-neoplastic epithelium adjacent to invasive SCCs was considered as normal tissue and both studies failed to demonstrate myofibroblasts in the approximal connective tissue,while these investigations showed an increased amount of myofibroblasts in the stroma of SCCs, which is in accordance with the results obtained in this study. None of the two studies had included oral epithelial dysplasia in their samples (19,21).…”

Section: Discussionsupporting

confidence: 80%

“…Dysplasia was not included in their study sample. Kellermann et al (2007) in a correspondence article reported the prognostic significance of myofibroblasts in SCC of the tongue, normal controls and premalignant leukoplakias with histological dysplasia. Similar to the current study, no myofibroblasts were found in the stroma of normal mucosa and epithelial dysplasia; however they were detected at the invasive front of the SCCs.…”

Section: Discussionmentioning

confidence: 99%

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Immunohistochemical Distribution of Myofibroblasts in Oral Squamous Cell Carcinoma, Verrucous Carcinoma and Oral Epithelial Dysplasia”

Majeed¹,

Yass²,

Sarkis³

2014

Iraqi dent. j.

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Background: Squamous cell carcinoma (SCC) is the most frequent type of oral malignancy that exhibits certain histological variations and is associated with a high mortality rate .Verrucous carcinoma (VC) is considered to be an uncommon exophytic distinctive low-grade well differentiated pathological variant of OSCC. Several studies have shown that the microenvironment or stroma of neoplastic tissues plays an active role in tumor progression. Concurrent with the conversion of non-diseased epithelial tissue to pre-cancerous epithelium to carcinoma, the stroma also changes from normal to primed (activated or tumor associated). Objective: The aim of this study was to compare the distribution of myofibroblasts in normal oral mucosa, oral epithelial dysplasia, verrucous carcinoma, and different histological grades of OSCC. Materials and methods: Twenty four formalin -fixed, paraffin -embedded tissue blocks (10 cases oral squamous cell carcinoma, 8 cases oral epithelial dysplasia and 6 cases verrucous carcinoma) were included in this study. An immunohistochemical analysis was performed using anti alpha -smooth muscle actin (a-SMA) monoclonal antibody. Results: All cases of OSCC, intraoral dysplasia and verruous carcinoma, and normal oral mucosa showed positive reaction of actin in the stromal smooth muscles surrounding blood and lymphatic vessels. All OSCCs demonstrated stromal immunostaining for a-SMA with different scores indicating the presence of myofibroblast. There were no myofibroblasts in the stroma of normal mucosa, epithelial dysplasia or verrucuos carcinoma samples indicated by negative a-SMA expression in them. Conclusion:The lack of myofibroblasts in normal, dysplastic oral epithelium and VC and their appearance in OSCC, suggests that the genetically altered epithelium (carcinomatous epithelium), besides the invasive behaviour of OSCC may have an inductive effect on the adjacent stroma to produce myofibroblasts.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Distribution of Myofibroblasts in Oral Squamous Cell Carcinoma, Verrucous Carcinoma and Oral Epithelial Dysplasia”

Majeed¹,

Yass²,

Sarkis³

2014

Iraqi dent. j.

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“…The intense SMA expression at the tumouradvancing front, was significantly associated with the N-stage and presence of nodal metastasis and its patterns are in keeping with previous studies (Kellermann et al, 2007;Surowiak et al, 2007;Marsh et al, 2011;Thode et al, 2011). The distribution of SMA immunoreactivity in the tumour stroma varies widely between different tumours and between different areas in the same tumour, and reflects heterogeneity (Vered et al, 2010).…”

Section: Discussionsupporting

confidence: 73%

“…Recent studies have also shown that the presence of activated fibroblasts, otherwise known as myofibroblasts, in the tumourassociated stroma are of high prognostic value in OSCC (Kellermann et al, 2007;Vered et al, 2010;Marsh et al, 2011). Myofibroblasts are usually demonstrated by the presence of alpha smooth muscle actin (SMA) expression, and their presence has also been shown to predict for disease recurrence across a number of tumour types (Surowiak et al, 2007;Tsujino et al, 2007).…”

mentioning

confidence: 99%

SERPINE1 and SMA expression at the invasive front predict extracapsular spread and survival in oral squamous cell carcinoma

Dhanda

Triantafyllou

Lilogou

et al. 2015

British Journal of Oral and Maxillofacial Surgery

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“…The induction of myofibroblasts by OSCC derived factors, that in turn promote carcinomatous proliferation, leading to neoplastic growth, has been demonstrated [12,13]. Studies have been conducted individually to evaluate the role of myofibroblasts in OSMF and OSCC.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Myofibroblasts By Expression of Alpha Smooth Muscle Actin: A Marker in Fibrosis, Dysplasia and Carcinoma

Rao

Narasimhan

Narashiman

et al. 2014

JCDR

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Myofibroblasts in the stroma of oral squamous cell carcinoma are associated with poor prognosis

Cited by 112 publications

References 7 publications

Immunohistochemical Distribution of Myofibroblasts in Oral Squamous Cell Carcinoma, Verrucous Carcinoma and Oral Epithelial Dysplasia”

Immunohistochemical Distribution of Myofibroblasts in Oral Squamous Cell Carcinoma, Verrucous Carcinoma and Oral Epithelial Dysplasia”

SERPINE1 and SMA expression at the invasive front predict extracapsular spread and survival in oral squamous cell carcinoma

Evaluation of Myofibroblasts By Expression of Alpha Smooth Muscle Actin: A Marker in Fibrosis, Dysplasia and Carcinoma

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