Myoepithelial carcinoma of intraoral minor salivary glands: a clinicopathological study of 7 cases and review of the literature

Yang, Shaodong; Li, Lü; Zeng, Ming; Zhu, Xiaojie; Zhang, Jiali; Chen, Xinming

doi:10.1016/j.tripleo.2010.02.023

Cited by 51 publications

(54 citation statements)

References 25 publications

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“…MECs are a rare group of tumors that account for 1-4% of salivary gland tumors and 0.2-0.32% of minor salivary gland tumors (2). MECs are diagnosed following the criteria of lesions that are composed almost exclusively of tumor cells, with myoepithelial differentiation and clear-cut tumor infiltration into adjacent tissue (6).…”

Section: Discussionmentioning

confidence: 99%

“…MECs account for 1-4% of all salivary gland tumors and arise predominantly from the major glands (1). Occasionally, MECs occur in the intraoral minor salivary glands and most frequently involve the palate (2). In the 2005 edition of the World Health Organization (WHO) histological classification of salivary gland tumors, MECs were considered to be low-grade tumors with a low tendency for local recurrence and metastasis (3).…”

Section: Introductionmentioning

confidence: 99%

“…In the 2005 edition of the World Health Organization (WHO) histological classification of salivary gland tumors, MECs were considered to be low-grade tumors with a low tendency for local recurrence and metastasis (3). MECs most commonly affect patients in their third to fifth decades of life, with a slight female predilection (2). The clinical prognosis of MECs is not well characterized, however, certain studies have suggested that MECs should be recognized as high-grade malignancies with a poor prognosis (4).…”

Section: Introductionmentioning

confidence: 99%

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Myoepithelial carcinoma of the vallecula: A case report and review of the literature

Wang

Zhang

2016

Oncology Letters

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Abstract. Myoepithelial carcinoma (MEC) of the vallecula is relatively rare, and there is no specific surgical guideline for resecting MEC in the vallecula. To the best of our knowledge, the current study reports the first case of MEC involving the vallecula of a 48-year-old female patient. In the present study, the lesion was correctly diagnosed as MEC and successfully managed using lateral pharyngotomy and by the construction of a sternohyoid myofascial flap. The patient was free of local recurrence or metastasis 18 months after surgery. The present study briefly reviews the current knowledge concerning the diagnosis and treatment of MECs in the head and neck area and offers suggestions for managing MEC in the vallecula. To conclude, MEC of the vallecula may be successfully managed by surgical treatment without evident post-surgery complications.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Myoepithelial carcinoma of the vallecula: A case report and review of the literature

Wang

Zhang

2016

Oncology Letters

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“…Generally, most MCs showed a low-grade malignancy, although certain reports of MC showed a high-grade malignancy and bad prognosis (2,7,8). As far as the treatment of MC is concerned, experience is limited, with complete surgical excision being mainstay of therapy (8).…”

Section: Discussionmentioning

confidence: 99%

“…MC was first described by Stromeyer et al in 1975, and was included in the World Health Organization (WHO) classification of salivary gland neoplasms as a distinct clinicopathological entity, in 1991. MC is rare, accounting for ~0.4-0.6% of the salivary gland tumors and 1.2-1.5% of carcinomas, as noted in a recent large series (2). It arises predominantly from the parotid glands, while other carcinomas occur in the submandibular or the accessory glands of the oral cavity.…”

Section: Introductionmentioning

confidence: 97%

Myoepithelial carcinoma inside of maxilla bone: A case report

Zhao

Zhu

Huang

2012

Molecular and Clinical Oncology

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Abstract. Myoepithelial carcinoma (MC) is a rare type of carcinoma occurring mainly in the parotid gland, while other carcinomas occur in submandibular or the accessory glands of the oral cavity. They may arise from the glands of the respiratory tract. However, primary MC of the bone is extremely rare. In the present study, a rare case of a 41-year-old woman with MC in the maxilla bone was reported. Following misdiagnosis as a bone cyst, a local excision was performed. The patient then presented with an extremely high malignancy and showed no response to chemoradiation treatment. The bone cyst was thought to be MC, thus early diagnosis with complete surgical excision was highly important. After confirmation of MC, a secondary extensive surgery may be crucial, following the primary local surgical resection.

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Developmental Morphology of the Palatine Glands in Rats: An Electron Microscope Study

Hakami

Hand

2018

The Anatomical Record

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Although minor salivary glands play a significant functional role in the oral cavity, their developmental morphology and cell differentiation has been scarcely studied. This study aimed to describe the development of rat palatine glands with regard to the ultrastructural morphology of the secretory cells and surrounding myoepithelial cells (MECs). Palatine glands from rats at embryonic ages (E) 18 and 20 days, and postnatal days (PN) 0, 3, 7, 10, 13, 21, 30, 42, and 60 were fixed and prepared for morphological analysis and immunocytochemical labeling of alpha‐smooth muscle actin (α‐SMA). At E18, epithelial cords were observed extending from the palatal epithelium and showed negative reactivity to α‐SMA. After luminization at E20, the cells of immature acini accumulated secretory granules of various densities: electron‐dense, electron‐lucent and some empty‐appearing granules. MECs were poorly differentiated at E20 and exhibited only slight α‐SMA expression. At birth, mucous and serous cells were typically located around a common lumen. Thereafter, serous cells began to move to the periphery to form demilunes by PN7. The mucous secretory granules of intermediate electron density became predominant around PN13. At PN21, these granules were dramatically reduced in number and most of the acini in adults contained acinar cells with numerous electron‐lucent granules, and a few serous demilune cells with electron‐dense granules. After birth, MECs progressively accumulated actin microfilaments until prominent α‐SMA expressing MECs invested the acini and the proximal part of the intercalated ducts in the adult. Anat Rec, 301:1820–1833, 2018. © 2018 Wiley Periodicals, Inc.

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Myoepithelial carcinoma of intraoral minor salivary glands: a clinicopathological study of 7 cases and review of the literature

Cited by 51 publications

References 25 publications

Myoepithelial carcinoma of the vallecula: A case report and review of the literature

Myoepithelial carcinoma of the vallecula: A case report and review of the literature

Myoepithelial carcinoma inside of maxilla bone: A case report

Developmental Morphology of the Palatine Glands in Rats: An Electron Microscope Study

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