1986
DOI: 10.1055/s-2007-1020402 View full text |Buy / Rent full text
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Abstract: This study was undertaken to evaluate the potential role of a perioperative calcium-channel blocker (Diltiazem) infusion in improving myocardial preservation. Forty consecutive CAD patients were randomly assigned to a control (C; n = 20) and a treated (D; n = 20) group. In patients in the latter group diltiazem was continuously infused at 0.5 to 2.0 mcg/kg/min i.v. from anesthesia induction until the aortic cross-clamping, and from myocardial reperfusion till the 48th postoperative hour. During the preCPB phas… Show more

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“…According to results of various studies, another calcium channel antagonist, diltiazem, combines systemic and coronary vasodi lation [7][8][9] with myocardial protection [10][11][12] and antiarrhythmic effects [13][14][15][16][17], It is well demonstrated that diltiazem has a direct effect on supraventricular tachycardias by its known influence on the atrioventricular conduction [13][14][15][16]18]. Diltiazem given parenterally is in up to 95% of patients successful in breaking the tachycardia and in restoring a regular sinus rhythm [19][20][21], Because it re presents the most frequent form of arrhyth mias in coronary surgery, the suppression of supraventricular tachycardias is of special clinical importance.…”
Section: Introductionmentioning
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“…According to results of various studies, another calcium channel antagonist, diltiazem, combines systemic and coronary vasodi lation [7][8][9] with myocardial protection [10][11][12] and antiarrhythmic effects [13][14][15][16][17], It is well demonstrated that diltiazem has a direct effect on supraventricular tachycardias by its known influence on the atrioventricular conduction [13][14][15][16]18]. Diltiazem given parenterally is in up to 95% of patients successful in breaking the tachycardia and in restoring a regular sinus rhythm [19][20][21], Because it re presents the most frequent form of arrhyth mias in coronary surgery, the suppression of supraventricular tachycardias is of special clinical importance.…”
Section: Introductionmentioning