Myocardial perfusion assessment in humans using steady‐pulsed arterial spin labeling

Capron, Thibaut; Troalen, Thomas; Robert, Benjamin; Jacquier, Alexis; Bernard, Monique; Kober, Frank

doi:10.1002/mrm.25479

Cited by 19 publications

(29 citation statements)

References 30 publications

(40 reference statements)

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“…In addition, MT effects are known to be greater when the duration between the tag pulse and read-out acquisition is substantially short (Capron et al, 2014). In our method, the TI time between Time-SLIP tag pulse and the read-out acquisition, is relatively long ranging from 103 to 1400 ms.…”

Section: Discussionmentioning

confidence: 97%

Non-contrast myocardial perfusion using a novel 4D magnetic resonance arterial spin labeling technique: Initial experience

Miyazaki

Zhou

Hoshino

et al. 2015

Microvascular Research

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Section: Discussionmentioning

confidence: 97%

Non-contrast myocardial perfusion using a novel 4D magnetic resonance arterial spin labeling technique: Initial experience

Miyazaki

Zhou

Hoshino

et al. 2015

Microvascular Research

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“…The time course of SPIL resembles the recently introduced steady‐pulsed ASL (spASL) approach to cardiac perfusion . However, SPIL and spASL differ in their geometry, specifically, in where labeling takes place.…”

Section: Discussionmentioning

confidence: 98%

Steady pulsed imaging and labeling scheme for noninvasive perfusion imaging

Qin

et al. 2015

Magnetic Resonance in Med

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Purpose A Steady Pulsed Imaging and Labeling (SPIL) scheme is proposed to obtain high-resolution multi-slice perfusion images of mice brain using standard preclinical MRI equipment. Methods The SPIL scheme repeats a pulsed arterial spin labeling (PASL) module together with a short mixing time to extend the temporal duration of the generated PASL bolus to the total experimental time. Multi-slice image acquisition takes place during the mixing times. The mixing time is also used for magnetization recovery following image acquisition. The new scheme is able to yield multi-slice perfusion images rapidly. The perfusion kinetic curve can be measured by a multi-pulsed imaging and labeling (MPIL) scheme, i.e., acquiring single-slice ASL signals before reaching steady-state in the SPIL sequence. Results When applying the SPIL method to normal mice, and to mice with unilateral ischemia, high-resolution multi-slice (5 slices) CBF images could be obtained in 8 minutes. Perfusion data from ischemic mice showed clear CBF reductions in in ischemic regions. The SPIL method was also applied to postmortem mice, showing that the method is free from magnetization transfer (MT) confounds. Conclusions The new SPIL scheme provides for robust measurement of CBF with multi-slice imaging capability in small animals.

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“…It would be interesting in future work to compare results between this free breathing FAIR technique and spASL introduced by Capron et al, which was also applied during free breathing, since in their study the authors compared the spASL data with FAIR ASL data acquired during breath holding and therefore limited to six label‐control pairs.…”

Section: Discussionmentioning

confidence: 99%

“…However, scan efficiency was compromised because of a 50% navigator acceptance rate, and therefore scan time was prolonged. Capron et al have also described a free breathing steady pulsed ASL (spASL) technique together with a retrospective image exclusion criterion using a contour‐based cross correlation algorithm, that resulted in discarding approximately 20% of the acquired data . However, this was only applied to spASL and not to FAIR ASL.…”

Section: Introductionmentioning

confidence: 99%

Optimal repetition time for free breathing myocardial arterial spin labeling

et al. 2019

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Arterial spin labeling (ASL) offers a noninvasive and repeatable measurement of tissue blood flow, but its application in the human heart is still challenging. The aim of this study was to improve the scan efficiency of flow-sensitive alternating inversion recovery (FAIR) ASL using a single inversion time. First, by evaluating a free breathing acquisition without navigators. Second, by shortening TR to acquire more ASL pairs.A FAIR ASL with balanced steady state free precession (bSSFP) readout was implemented at 3 T and tested in 14 healthy volunteers. Three cardiac-triggered ASL scans with different TRs were compared while maintaining a constant acquisition time.These scans were named by the trigger pulse (TP) that started each acquisition: every two (TP1), four (TP2) and six (TP3) cardiac cycles. Two studies were performed on different days to assess the reproducibility of TP2 and TP3 scans. Perfusion response during passive leg raising was also evaluated. Student t-test and nonparametric equivalent were computed for perfusion differences. Bland-Altman and coefficient of variation (CV) were calculated for the reproducibility assessment.Mean myocardial blood flow (MBF) values measured at rest were: 1.47 ± 0.91 ml/g/min (TP1), 1.95 ± 0.93 ml/g/min (TP2) and 1.94 ± 1.41 ml/g/min (TP3). Intrasession CV was 17.15% (TP2) and 24.17% (TP3) and intersession CV was 36.86% (TP2) and 18.38% (TP3). Mean MBF was found to increase with passive stress by 0.22 ± 0.41 ml/g/min for TP2 (P = 0.037).Mean MBF values were consistent with the literature, although in the high end of the normal range. The lower MBF values measured in TP1 scans are attributable to saturation of blood outside the slice because of shorter TR. Free breathing FAIR cardiac ASL without navigators is feasible. A TR of approximately four seconds (TP2) offers the best alternative with similar mean ASL and tSNR than longer TR acquisitions.

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Myocardial perfusion assessment in humans using steady‐pulsed arterial spin labeling

Abstract: spASL was able to quantify MBF in healthy subjects under free breathing. Because quantification with ASL is more direct than with first-pass perfusion MRI, it appears particularly suited for pathologies with diffuse microvascular alterations, MBF reserve, and follow-up studies.

Cited by 19 publications

References 30 publications

Non-contrast myocardial perfusion using a novel 4D magnetic resonance arterial spin labeling technique: Initial experience

Non-contrast myocardial perfusion using a novel 4D magnetic resonance arterial spin labeling technique: Initial experience

Steady pulsed imaging and labeling scheme for noninvasive perfusion imaging

Optimal repetition time for free breathing myocardial arterial spin labeling

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