Myocardial ischemia and infarction can be detected by microwave spectroscopy. II. Biophysical reconstruction

Semenov, Serguei; Svenson, Robert H.; Dezern, Kathy R.; Quinn, Michael; Thompson, Martha E.; Tatsis, Giorgos

doi:10.1109/iembs.1996.647455

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“…The ion conductivity part at high frequencies was reconstructed fiom measured dielectric properties at the microwave spectrum. This reconstruction was performed based on a multicomponent model, the myocardial dielectric properties in the microwave spectrum were described in a complex form as free water, bound water and protein relaxations with corresponding volume fractions and ion conductivity [2].…”

Section: Introductionmentioning

confidence: 99%

Dielectric properties of canine acute and chronic myocardial infarction at a cell relaxation spectrum. II. Theory

Semenov

Svenson

Simonova³

et al. 1997

Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent M

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A new model of bulk myocardium dielectric properties as a composition of membrane covered cells modelled as infinite cylinders has been developed. This model utilizes the complex values of dielectric properties of the intracellular, extracellular media and the cellular membrane. The model was used to analyze the myocardial resistivity above and below the cell membrane relaxation spectrum in normal myocardium and in acute and chronic infarction. This myocardium cell model gives reasonable qualitative explanation not only for the spectrum of normal myocardial resistance but also for observed changes in the spectrum of myocardial resistance in acute ischemia and chronic infarction based on the "volume fraction hypothesis".The contributions of intracellular, extracellular and cell membrane resistances to bulk myocardial resistance are frequency dependent. At frequencies below 0.2MHz the intracellular contribution to bulk resistance is much smaller compared to the extracellular resistance and does not exceed 10-15%. At frequencies higher than O.5MHz the measured bulk resistance reflects extracellular and intracellular resistances at about the same order. The contribution of the cell membrane resistance is much smaller compared to the intracellular and extracellular resistances and does not exceed 0.1 % at frequency near 1Hz for normal myocardium . .

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Section: Introductionmentioning

confidence: 99%