Myocardial injury in a 100-km ultramarathon

Musha, Haruki; Nagashima, Junzo; Awaya, Toru; Oomiya, Kazuto; Takada, Hideomi; Murayama, Masahiro

doi:10.1016/s0011-393x(97)80085-9

Cited by 14 publications

(10 citation statements)

References 17 publications

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“…It is known that CPK levels increase after great physiological stress [10][11][12][13][14][15][16][17] , indicating intense catabolic state of skeletal muscle. The intensity and duration of physical exercise are commonly associated with CPK increase and there seems to be a predominant effect of duration 16 .…”

Section: Discussionmentioning

confidence: 99%

“…Several studies, such as ours, showed no elevation in TnT, even with significant increases in CKMB [24][25][26][27][28] . Others showed an increase of this marker in a heterogeneous group of athletes [29][30][31][32][33] , although it is not known whether this increase really reflects myocardial damage and what the determinants of alteration are in just some athletes.…”

Section: Passaglia Et Al Effects Of Prolonged Physical Exercisementioning

confidence: 97%

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Efeitos agudos do exercício físico prolongado: avaliação após ultramaratona de 24 horas

Passaglia¹,

Emed²,

Barberato³

et al. 2013

Arq. Bras. Cardiol.

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Section: Discussionmentioning

confidence: 99%

Section: Passaglia Et Al Effects Of Prolonged Physical Exercisementioning

confidence: 97%

Efeitos agudos do exercício físico prolongado: avaliação após ultramaratona de 24 horas

Passaglia¹,

Emed²,

Barberato³

et al. 2013

Arq. Bras. Cardiol.

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“…Some authors have recently suggested that intense endurance exercise may induce subclinical myocardial injury in healthy athletes [20,26]. This assumption, however, was only based on the observation of elevated TnT-c levels after a marathon [20] or ultramarathon [26] without any additional evidence of heart damage (i.e. echocardiographic parameters).…”

Section: Discussionmentioning

confidence: 99%

“…marathon running) [1,6,11,12,14,21,27,28], the exact muscle source of released intracellular components is often difficult to interpret. Moreover, few reports have shown controversial results using more specific markers for detecting myocardial injury such as cardiac troponin T (TnT-c) or I (TnI-c) [1,9,11,12,20,21,25,26,32].…”

Section: Introductionmentioning

confidence: 99%

Short-Term Effects of Marathon Running in Master Runners: No Evidence of Myocardial Injury

Lucía¹,

Moran²,

Pérez³

et al. 1999

Int J Sports Med

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The purpose of this investigation was to analyze the short-term effects of marathon running on serum levels of cardiac markers in a group of master runners (> 60 yrs). Ten marathoners (9 male and 1 female; 63+/-4 yrs) were enrolled in the study. All of them completed the Madrid Marathon (1998). Venous blood was drawn from each subject three times during the study (48 h before the race, immediately after the race, and 24 h post-competition) for the determination of the several biochemical markers, such as total creatine kinase catalytic activity (total CK), mass concentration of creatine kinase isoenzyme MB (CK-MB mass), and cardiac troponin I (Tnl-c). The most important finding was that in each sample (pre- or post-race) serum Tnl-c was below the commonly accepted level of 0.1 ng x m(-1) indicative of myocardial injury. Although further research is needed using more complete methodology, our results suggest that marathon running does not have an acute deleterious effect on the hearts of the elderly.

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“…Furthermore, echocardiographic measurements showed no significant regional abnormalities post‐race. Several studies found evidence of reduced LV function following prolonged exercise (Laslett et al, 1996; Musha et al, 1997; Tanabe et al, 1999; D'Andrea et al, 2002; Neumayr et al, 2002). Other studies, however, found no significant change in several echocardiographic indicators of LV function following endurance exercise (Lucia et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Myocardial response to a triathlon in male athletes evaluated by Doppler tissue imaging and biochemical parameters

Leetmaa¹,

Dam²,

Glintborg³

et al. 2008

Scandinavian Med Sci Sports

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The aim of this study was to examine cardiac dysfunction following ultra-endurance exercise in male athletes. Fourteen athletes (mean+/-SD, age 39+/-8 years) were evaluated before and after the European Championship in Triathlon 2003 using echocardiogram (ECG), cardiac markers [cardiac troponin T (cTnT) and pro-brain natriuretic peptide (pro-BNP)] and echocardiography. Conventional echocardiography techniques and new Doppler tissue imaging (DTI) modalities were applied before and immediately after the competition. Blood samples were drawn 1 week before, immediately after and 12-24 h post-competition. CTnT significantly increased immediately, but decreased to within normal limits 12-24 h post-competition. Pro-BNP was significantly increased immediately post-race (27+/-21 vs 7+/-2 pmol/L pre-race, P < or = 0.007), which 12-24 h later, decreased to 19+/-14 pmol/L (P = 0.07 vs pre-race). During echocardiography, no significant differences were found in regional or global systolic parameters. Early diastolic peak flow velocity (9+/-2, P = 0.04) and E/A ratio (2+/-1, P = 0.004) were increased pre-race and decreased significantly toward normal values. In one athlete, cTnT levels increased significantly and systolic velocities decreased, thus suggesting reversible cardiac fatigue. When using cardiac markers and echocardiographic findings, a triathlon was found to have no significant negative effects on left ventricular function or myocardial tissue in male athletes.

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Myocardial injury in a 100-km ultramarathon

Cited by 14 publications

References 17 publications

Efeitos agudos do exercício físico prolongado: avaliação após ultramaratona de 24 horas

Efeitos agudos do exercício físico prolongado: avaliação após ultramaratona de 24 horas

Short-Term Effects of Marathon Running in Master Runners: No Evidence of Myocardial Injury

Myocardial response to a triathlon in male athletes evaluated by Doppler tissue imaging and biochemical parameters

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