Myocardial high energy phosphate metabolism during ventricular fibrillation with total circulatory arrest

Insights From the Ventricular Fibrillation Waveform Into the Mechanism of Survival Benefit From Bystander Cardiopulmonary Resuscitation

“…Ventricular fibrillation waveform measures have been associated with myocardial physiological status (adenosine triphosphate stores), suggesting that bystander CPR may work to improve survival through a primary cardiac mechanism. 31 , 32 Although perhaps not surprising, the current results help validate experimental research demonstrating CPR mechanisms related to coronary perfusion and oxygen delivery and their influence on myocardial energetics. 33 , 34 , 35 The VF waveform measures mediated between a quarter to half of the survival benefit, depending on the specific measure.…”

Insights From the Ventricular Fibrillation Waveform Into the Mechanism of Survival Benefit From Bystander Cardiopulmonary Resuscitation

“…Ventricular fibrillation waveform measures have been associated with myocardial physiological status (adenosine triphosphate stores), suggesting that bystander CPR may work to improve survival through a primary cardiac mechanism. 31 , 32 Although perhaps not surprising, the current results help validate experimental research demonstrating CPR mechanisms related to coronary perfusion and oxygen delivery and their influence on myocardial energetics. 33 , 34 , 35 The VF waveform measures mediated between a quarter to half of the survival benefit, depending on the specific measure.…”

Moderate Kidney Dysfunction Independently Increases Sudden Cardiac Arrest Risk: A Community‐Based Study

“…Furthermore, they often have anemia, which limits cell energy and makes the cardiac myocytes more vulnerable to global myocardial energy depletion, contributing to nonshockable rhythms. 42 , 46 Moreover, SCA cases with moderate CKD had worse outcomes, with lower survival rates to hospital discharge compared with those with normal or mild CKD. This finding can be explained by the higher proportion of nonshockable rhythms, which were associated with poorer outcomes, and by the additional burden of CKD, which involves electrolyte and fluid imbalances.…”

Moderate Kidney Dysfunction Independently Increases Sudden Cardiac Arrest Risk: A Community-Based Study

“…Furthermore, CKD patients often have anemia, which limits cell energy and makes the cardiac myocytes more vulnerable to global myocardial energy depletion, contributing to non-shockable rhythms. 29,33 Moreover, SCA cases with moderate CKD had worse outcomes, with lower survival rates to hospital discharge compared to those with normal or mild CKD. This finding can be explained by the higher proportion of non-shockable rhythms, which were associated with poorer outcomes, and by the additional burden of CKD, which involves electrolyte and fluid imbalances.…”

Insights From the Ventricular Fibrillation Waveform Into the Mechanism of Survival Benefit From Bystander Cardiopulmonary Resuscitation

“…Ventricular fibrillation waveform measures have been associated with myocardial physiological status (adenosine triphosphate stores), suggesting that bystander CPR may work to improve survival through a primary cardiac mechanism. 31 , 32 Although perhaps not surprising, the current results help validate experimental research demonstrating CPR mechanisms related to coronary perfusion and oxygen delivery and their influence on myocardial energetics. 33 , 34 , 35 The VF waveform measures mediated between a quarter to half of the survival benefit, depending on the specific measure.…”

Moderate Kidney Dysfunction Independently Increases Sudden Cardiac Arrest Risk: A Community‐Based Study

“…Furthermore, they often have anemia, which limits cell energy and makes the cardiac myocytes more vulnerable to global myocardial energy depletion, contributing to nonshockable rhythms. 42 , 46 Moreover, SCA cases with moderate CKD had worse outcomes, with lower survival rates to hospital discharge compared with those with normal or mild CKD. This finding can be explained by the higher proportion of nonshockable rhythms, which were associated with poorer outcomes, and by the additional burden of CKD, which involves electrolyte and fluid imbalances.…”

Moderate Kidney Dysfunction Independently Increases Sudden Cardiac Arrest Risk: A Community-Based Study

“…Furthermore, CKD patients often have anemia, which limits cell energy and makes the cardiac myocytes more vulnerable to global myocardial energy depletion, contributing to non-shockable rhythms. 29,33 Moreover, SCA cases with moderate CKD had worse outcomes, with lower survival rates to hospital discharge compared to those with normal or mild CKD. This finding can be explained by the higher proportion of non-shockable rhythms, which were associated with poorer outcomes, and by the additional burden of CKD, which involves electrolyte and fluid imbalances.…”

Insights From the Ventricular Fibrillation Waveform Into the Mechanism of Survival Benefit From Bystander Cardiopulmonary Resuscitation

“…Ventricular fibrillation waveform measures have been associated with myocardial physiological status (adenosine triphosphate stores), suggesting that bystander CPR may work to improve survival through a primary cardiac mechanism. 31 , 32 Although perhaps not surprising, the current results help validate experimental research demonstrating CPR mechanisms related to coronary perfusion and oxygen delivery and their influence on myocardial energetics. 33 , 34 , 35 The VF waveform measures mediated between a quarter to half of the survival benefit, depending on the specific measure.…”

Moderate Kidney Dysfunction Independently Increases Sudden Cardiac Arrest Risk: A Community‐Based Study

“…Furthermore, they often have anemia, which limits cell energy and makes the cardiac myocytes more vulnerable to global myocardial energy depletion, contributing to nonshockable rhythms. 42 , 46 Moreover, SCA cases with moderate CKD had worse outcomes, with lower survival rates to hospital discharge compared with those with normal or mild CKD. This finding can be explained by the higher proportion of nonshockable rhythms, which were associated with poorer outcomes, and by the additional burden of CKD, which involves electrolyte and fluid imbalances.…”

Moderate Kidney Dysfunction Independently Increases Sudden Cardiac Arrest Risk: A Community-Based Study

“…Furthermore, CKD patients often have anemia, which limits cell energy and makes the cardiac myocytes more vulnerable to global myocardial energy depletion, contributing to non-shockable rhythms. 29,33 Moreover, SCA cases with moderate CKD had worse outcomes, with lower survival rates to hospital discharge compared to those with normal or mild CKD. This finding can be explained by the higher proportion of non-shockable rhythms, which were associated with poorer outcomes, and by the additional burden of CKD, which involves electrolyte and fluid imbalances.…”