Myocardial CT perfusion imaging for ischemia detection

Carrascosa, Patrícia; Capuñay, Carlos

doi:10.21037/cdt.2017.04.07

Cited by 7 publications

(5 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If stress imaging is pursued, a delay of 10–20 min following rest imaging should be implemented to ensure adequate contrast washout. ECG-based tube current modulation is recommended to reduce radiation dose [ 68 ]. In addition to the evaluation of stable chest pain in the outpatient setting, rest-stress CTP protocols may be ideal for the evaluation of acute chest pain in the emergency department, leveraging both the quality data and high NPV of CCTA in the ED with the ability to further evaluate indeterminate lesions and incrementally increase appropriate disposition [ 69 ].…”

Section: Ct Perfusion Protocolsmentioning

confidence: 99%

Myocardial Assessment with Cardiac CT: Ischemic Heart Disease and Beyond

Ramsey

Fentanes

Choi

et al. 2018

Curr Cardiovasc Imaging Rep

View full text Add to dashboard Cite

Purpose of ReviewThe aim of this review is to highlight recent advancements, current trends, and the expanding role for cardiac CT (CCT) in the evaluation of ischemic heart disease, nonischemic cardiomyopathies, and some specific congenital myocardial disease states.Recent FindingsCCT is a highly versatile imaging modality for the assessment of numerous cardiovascular disease states. Coronary CT angiography (CCTA) is now a well-established first-line imaging modality for the exclusion of significant coronary artery disease (CAD); however, CCTA has modest positive predictive value and specificity for diagnosing obstructive CAD in addition to limited capability to evaluate myocardial tissue characteristics.SummaryCTP, when combined with CCTA, presents the potential for full functional and anatomic assessment with a single modality. CCT is a useful adjunct in select patients to both TTE and CMR in the evaluation of ventricular volumes and systolic function. Newer applications, such as dynamic CTP and DECT, are promising diagnostic tools offering the possibility of more quantitative assessment of ischemia. The superior spatial resolution and volumetric acquisition of CCT has an important role in the diagnosis of other nonischemic causes of cardiomyopathies.

show abstract

Section: Ct Perfusion Protocolsmentioning

confidence: 99%

Myocardial Assessment with Cardiac CT: Ischemic Heart Disease and Beyond

Ramsey

Fentanes

Choi

et al. 2018

Curr Cardiovasc Imaging Rep

View full text Add to dashboard Cite

show abstract

“…In this study, there was overexpression of MTA1 in tumor tissues in elderly NSCLC patients with spicule sign, pleural indentation sign and lymph node metastasis sign in CT images, indicating that patients with high expression of MTA1 are more prone to spicule sign, pleural indentation sign and lymph node metastasis sign. CT perfusion imaging technique can continuously scan the lesion area after high-pressure intravenous injection of contrast agent, thereby reflecting the hemodynamics of tumor tissues (22,23). In this study, there were no obvious differences in BV, BF and TTP between high expression MTA1 group and low expression MTA1 group.…”

Section: Discussionmentioning

confidence: 54%

Associations of MTA1 expression with CT features, pathology and prognosis of elderly patients with non-small cell lung cancer

Han

Feng

et al. 2020

Oncol Lett

View full text Add to dashboard Cite

Associations of metastasis-associated protein 1 (MTA1) expression with computed tomography (CT) features, pathology and prognosis of elderly patients with non-small cell lung cancer (NSCLC), and its clinical significance were explored. A total of 98 elderly patients with NSCLC were selected and underwent CT examination. The expression of MTA1 in carcinoma tissues and para-carcinoma normal tissues was detected via immunohistochemistry, and its associations with CT features, pathology and prognosis were analyzed. The results manifested that the expression of MTA1 in carcinoma tissues was significantly higher than that in para-carcinoma normal tissues, and it was associated with the degree of differentiation, stage and lymph node metastasis (P<0.05). Besides, the high expression of MTA1 was also related to the spicule sign, pleural indentation and lymph node metastasis (P<0.05) as well as the CT perfusion parameter capillary permeability (PMB) (P<0.05), but not to blood volume (BV), blood flow (BF) or time to peak (TTP). Moreover, the patients with high expression of MTA1 had significantly shorter survival time and a remarkably lower 5-year survival rate than those with low expression of MTA1 (P<0.05). In conclusion, MTA1 plays a certain role in the occurrence and development of NSCLC in elderly patients and has an association with their prognosis, which can provide references for the treatment and prognosis of NSCLC, with important clinical significance.

show abstract

“…In this work we aim to evaluate the use of ECGI imaging to detect ischemic lesion using a virtual ventricle-torso model. While ECGI may not provide an alternative to conventional imaging techniques (Daly and Kwong, 2013; Carrascosa and Capunay, 2017; Carvalho et al, 2017), it is important to fully evaluate the ECGI technique to assess its strengths and weaknesses and assess how much information could be potentially recovered.…”

Section: Introductionmentioning

confidence: 99%

ECG Imaging to Detect the Site of Ventricular Ischemia Using Torso Electrodes: A Computational Study

Kara

Alday

et al. 2019

Front. Physiol.

View full text Add to dashboard Cite

Electrocardiography provides some information useful for ischemic diagnosis. However, more recently there has been substantial growth in the area of ECG imaging, which by solving the inverse problem of electrocardiography aims to produce high-resolution mapping of the electrical and magnetic dynamics of the heart. Most inverse studies use the full resolution of the body surface potential (BSP) to reconstruct the epicardial potentials, however using a limited number of torso electrodes to interpolate the BSP is more clinically relevant and has an important effect on the reconstruction which must be quantified. A circular ischemic lesion on the right ventricle lateral wall 27 mm in radius is reconstructed using three Tikhonov methods along with 6 different electrode configurations ranging from 32 leads to 1,024 leads. The 2nd order Tikhonov solution performed the most accurately (~80% lesion identified) followed by the 1st (~50% lesion identified) and then the 0 order Tikhonov solution performed the worst with a maximum of ~30% lesion identified regardless of how many leads were used. With an increasing number of leads the solution produces less error, and the error becomes more localised around the lesion for all three regularisation methods. In noisy conditions, the relative performance gap of the 1st and 2nd order Tikhonov solutions was reduced, and determining an accurate regularisation parameter became relatively more difficult. Lesions located on the left ventricle walls were also able to be identified but comparatively to the right ventricle lateral wall performed marginally worse with lesions located on the interventricular septum being able to be indicated by the reconstructions but not successfully identified against the error. The quality of reconstruction was found to decrease as the lesion radius decreased, with a lesion radius of <20 mm becoming difficult to correctly identify against the error even when using >512 torso electrodes.

show abstract

Myocardial CT perfusion imaging for ischemia detection

Cited by 7 publications

References 82 publications

Myocardial Assessment with Cardiac CT: Ischemic Heart Disease and Beyond

Myocardial Assessment with Cardiac CT: Ischemic Heart Disease and Beyond

Associations of MTA1 expression with CT features, pathology and prognosis of elderly patients with non-small cell lung cancer

ECG Imaging to Detect the Site of Ventricular Ischemia Using Torso Electrodes: A Computational Study

Contact Info

Product

Resources

About