MYH9 and APOL1 Gene Polymorphisms and the Risk of CKD in Patients with Lupus Nephritis from an Admixture Population

Colares, Vinícius Sardão; Titan, Silvia Maria de Oliveira; Pereira, Alexandre da Costa; Malafronte, Patrícia; Cardena, M.M.S.G.; Santos, Sidney Emanuel Batista dos; Santos, P. Marques Dos; Fridman, Cíntia; Barros, Rui Toledo; Woronik, Viktoria

doi:10.1371/journal.pone.0087716

Cited by 26 publications

(28 citation statements)

References 30 publications

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“…In fact, this synergistic effect may play a role in the pathogenic characteristics of a gene. For instance, previous studies ( 22 , 23 ) showed that many haplotypes can increase the individual disease risk.…”

Section: Introductionmentioning

confidence: 99%

Association between polymorphisms in the APOB gene and hyperlipidemia in the Chinese Yugur population

Han

et al. 2017

Braz J Med Biol Res

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We investigated the influence of apolipoprotein B gene (APOB) variants on the risk of hyperlipidemia (HL) in 631 middle-aged and elderly members of the Chinese Yugur population (HL, n=336; normolipidemia, n=295). APOB polymorphisms were identified using mass spectrometry, and five single nucleotide polymorphisms (rs1042034, rs2163204, rs512535, rs676210, and rs679899) and serum lipids were further analyzed. rs1042034 and rs676210 were significantly associated with HL (P<0.05). Compared with the GG or AA genotype, individuals with AG and AG+AA in rs1042034 and with AG and AG+GG in rs676210 had a 1.67-fold (95%CI=1.20–2.33),1.63-fold (95%CI=1.19–2.24), 1.72-fold (95%CI=1.24–2.40), and 1.67-fold (95%CI=1.21–2.291) increased risk of high HL, respectively. rs2163204 was in strong linkage disequilibrium with rs1042034, rs676210, and rs679899, and strong disequilibrium was observed between rs1042034 and rs676210 (D′>0.9). Compared with the GTGAA haplotype, haplotypes ATGGA and ATAGG were more strongly associated with HL [odds ratio (OR)=1.46, 95%CI=0.02–2.11; OR=1.63, 95%CI=1.03–2.60, respectively]. The risk factors age (P=0.008), body mass index (P<0.0001), GA+GG genotype in rs676210 (P=0.009), and alcohol consumption (P=0.056) contributed strongly to HL development. The A allele of rs1042034 and the G allele of rs676210 may thus predispose middle-aged and elderly members of the Chinese Yugur population to HL in combination with other genetic or nutritional factors, and could be used as new genetic markers for HL screening.

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Section: Introductionmentioning

confidence: 99%

Association between polymorphisms in the APOB gene and hyperlipidemia in the Chinese Yugur population

Han

et al. 2017

Braz J Med Biol Res

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“…However, it was proposed that the gene APOL1 is more intensely associated with CKD than the MYH9 gene [36,37]. But to the best of our knowledge, these are reported from the different parts of the world, especially by analysing the data obtained from the populations of African, African-Americans, Brazilians and European-Americans [35,[38][39][40]. However, there are no reports existing in the literature describing the role of APOL1 or MYH9 genes or their genetic polymorphisms in CKD of Indian population [41,42].…”

Section: This Article Is Part Of the Topical Collection On Medicinementioning

confidence: 94%

“…On the other hand, there are several reports suggesting the role of genetic polymorphisms in the genes APOL1 and MYH9 and their role in CKD. From the literature survey, we observed that the genes APOL1 and MYH9 cosegregate with each other [35]. However, it was proposed that the gene APOL1 is more intensely associated with CKD than the MYH9 gene [36,37].…”

Section: This Article Is Part Of the Topical Collection On Medicinementioning

confidence: 99%

Uddanam Kidney Nephropathy Under the Light of Metagenomics Perspective

Arun

Reddy

Akhter

2018

SN Compr. Clin. Med.

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In this work, we proposed a research hypothesis which mainly focuses on the role of gut microbiota, in relation with chronic kidney disease, existing in the village of Uddanam belonging to the State of Andhra Pradesh, India. Earlier studies conducted on various physical and chemical parameters, such as food, water, soil and pesticides, could not find the exact cause of the aetiology of the disease. As there were no physical and chemical causative factors identified, this disease was hence named as mysterious Uddanam kidney nephropathy of unknown origins. There are few scientific pieces of evidence available in the literature, which suggests the role of gut microbiome dysbiosis and its impact on kidney disease. Such kinds of scientific studies which deal with the analysis of microbial communities of the gut region and identification of dysbiosis were not performed in the case of Uddanam kidney nephropathy. Thus, through this paper, we propose a hypothesis to analyse and establish the relationship between the gut dysbiosis and renal failure by performing the metagenomics study between the patients and the normal individuals. To the best of our knowledge, there are no reports available to date on the dysbiosis of the gut microbiome and its impact on Uddanam nephropathy and hence this research hypothesis is thus proposed.

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“…In a mixed Brazilian population, MYH9 gene polymorphisms (but not APOL1) were associated with a risk of progression of CKD [36]. In African American patients with SLE, APOL1 G1 and G2 risk alleles were strongly associated with end-stage renal disease (ESRD) even after adjustment for age, sex and ancestry [37].…”

Section: Ethnicity and Outcome Of Sle And Lnmentioning

confidence: 99%

Lupus Nephritis: A Different Disease in European Patients?

Tesař

Hrušková²

2015

Kidney Dis

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Background: Lupus nephritis (LN) is still associated with significant mortality and substantial risk of progression to end-stage renal failure. Its outcome is related to the class and severity of LN and response to treatment, and it is poorer in patients with renal relapses. Ethnicity has a relatively well-defined impact on the outcome of the patients and their response to treatment and must always be taken into consideration in treatment decisions. Summary: In this article, we provide a review of the impact of ethnicity on the prevalence of systemic lupus erythematosus (SLE), the proportion of patients with SLE developing LN, outcomes of SLE and LN and response of LN to treatment. In European patients, the prevalence of SLE and the proportion of SLE patients with LN are lower and the outcome of LN is better than in nonwhite populations. European patients may respond better to some modes of treatment [e.g. cyclophosphamide (CYC) or rituximab] and may be less frequently refractory to treatment compared to black patients with LN. Although these differences may be largely genetically driven, socioeconomic factors (poverty, education, insurance, access to health care and adherence to treatment) may also play a significant role in some disadvantaged patients. Key Message: Treatment of LN may be different in patients with different ethnicity. Less aggressive disease in European patients may better respond to less aggressive treatment. Treatment of LN in nonwhite patients may require newer (more effective) therapeutic approaches, but targeting negative socioeconomic factors might be even more effective. Facts from East and West: (1) The prevalence of SLE is lower among Caucasians than other ethnicities. A higher prevalence is observed among Asians and African Americans, while the highest prevalence is found in Caribbean people. The prevalence of LN in Asian SLE patients is much higher than in Caucasians as well. However, the 10-year renal outcome and renal survival rate appear to be better in Asians. (2) Polymorphisms of genes involved in the immune response, such as Fcγ receptor, integrin alpha M, TNF superfamily 4, myotubularin-related protein 3 and many others, might be partly responsible for the differences in prevalence between the different ethnic groups. European ancestry was shown to be associated with a decrease in the risk of LN even after adjustment for genes most associated with renal disease. (3) Access to health care is a key determinant of disease progression, treatment outcome and the management of complications such as infections, particularly in South Asia, and might also explain disparities between clinical outcomes. (4) The efficacy of low-dose CYC combined with corticosteroids for induction treatment of LN was proved in European Caucasian patients. This treatment is also used in Asia, although no formal evaluation of efficacy and safety in comparison with other treatment regimens exists in this population. The efficacy of mycophenolate mofetil (MMF) is similar to that of CYC, and similar between Asi...

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MYH9 and APOL1 Gene Polymorphisms and the Risk of CKD in Patients with Lupus Nephritis from an Admixture Population

Cited by 26 publications

References 30 publications

Association between polymorphisms in the APOB gene and hyperlipidemia in the Chinese Yugur population

Association between polymorphisms in the APOB gene and hyperlipidemia in the Chinese Yugur population

Uddanam Kidney Nephropathy Under the Light of Metagenomics Perspective

Lupus Nephritis: A Different Disease in European Patients?

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