Myelotoxicity and kidney dysfunction related to the use of trimethoprim-sulfamethoxazole for the treatment of Pneumocystis jirovecii pneumonia: a case report of severe adverse events with a common drug
Isabel Cristina Melo Mendes,
Roxana Flores Mamani,
David Richer Araujo Coelho
et al.
Abstract:Trimethoprim-sulfamethoxazole (TMP-SMX) is the primary therapeutic option for
Pneumocystis jirovecii
pneumonia (PCP). Gastrointestinal symptoms and cutaneous rash are common side effects, with hyperkalemia being uncommon in patients without kidney dysfunction, and myelotoxicity being even rarer. We present the case of a male patient with hypertension and a recent diagnosis of non-Hodgkin lymphoma, undergoing rituximab treatment for two months. He was admitted to the intensive care unit d… Show more
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