Myeloperoxidase serves as a marker of oxidative stress during single haemodialysis session using two different biocompatible dialysis membranes

Wu, Chia Chao; Chen, Jin Shuen; Wu, Wen-Yih; Liao, Tung Nan; Chu, Pauling; Lin, Shih Hua; Chuang, Chien Huei; Lin, Yuh Feng

doi:10.1093/ndt/gfh764

Cited by 78 publications

(66 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Myeloperoxidase is an important marker of oxidative stress during HD sessions (9,20) and is associated with chronic mild inflammation (21). Interestingly, serum MPO as well as oxAT correlated with female gender in multivariate models in the present study (Tables 1 and 2), whereas another study has not found a significant association between MPO and gender in patients under HD (11).…”

Section: Discussioncontrasting

confidence: 61%

Assessment of Myeloperoxidase and Oxidative α1-Antitrypsin in Patients on Hemodialysis

Honda¹,

Ueda²,

Kojima³

et al. 2009

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Background and objectives: The present study assesses the effects of the oxidative stress marker, myeloperoxidase (MPO), and the possible MPO-related oxidative stress marker, oxidative ␣ 1 -antitrypsin (oxAT), on carotid intima-media thickness (CIMT) and protein-energy wasting (PEW) in patients on hemodialysis (HD).Design, setting, participants, & measurements: Blood samples were obtained from 383 patients before HD to measure WBC count, serum albumin, lipids, high-sensitivity C-reactive protein (CRP), ␣ 1 -antitrypsin (AT), interleukin-6, oxidative LDL-C, MPO, and oxAT. We assessed both CIMT and the geriatric nutritional risk index (GNRI) in this cross-sectional competitive study.Results: Levels of MPO and oxAT correlated. Myeloperoxidase was associated with max-CIMT, and oxAT correlated with max-CIMT and GNRI. Multivariate linear regression models showed that MPO and oxAT were independent predictors of increasing max-CIMT, whereas oxAT, but not MPO, independently correlated with GNRI. In four combined MPO and oxAT groups classified according to median values, a multinomial logistic regression model showed that high MPO together with high oxAT was independently associated with increased max-CIMT. Moreover, the OR for max-CIMT with positive PEW and high MPO was significantly increased in the four groups with combined MPO and PEW.Conclusions: High MPO with high oxAT and high MPO with PEW seem to contribute to plaque formation in patients on HD, whereas elevated MPO or oxAT alone might not predict increasing CIMT. In contrast, a high oxAT value seems to be an independent predictor of PEW in patients on HD.

show abstract

Section: Discussioncontrasting

confidence: 61%

Assessment of Myeloperoxidase and Oxidative α1-Antitrypsin in Patients on Hemodialysis

Honda¹,

Ueda²,

Kojima³

et al. 2009

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

show abstract

“…The results of the present study are in agreement with that of others [9,13] who have also shown a significant rise in MPO after a single dialysis session. MPO is abundantly stored in the primary granulocytes of PMNs and is secreted by activated neutrophils [3].…”

Section: Discussionsupporting

confidence: 93%

“…So far, very few studies [7,8] have demonstrated that dialysis results in neutrophil activation and release of MPO. Also, MPO has been considered as an important pathophysiological factor during the HD process and may serve as a reliable indicator of oxidative stress [9]. Our earlier study carried out on patients with chronic kidney disease who were not on dialysis, has shown that plasma MPO levels declined progressively and significantly with advancing stages of renal failure [10].…”

Section: Introductionmentioning

confidence: 99%

Effect of Hemodialysis on Plasma Myeloperoxidase Activity in End Stage Renal Disease Patients

Rao¹,

Apoorva²,

Anand³

et al. 2012

Ind J Clin Biochem

View full text Add to dashboard Cite

“…Although contradictious results are present, most of other studies support our data. [17][18][19][20] Erythrocytes SOD levels, a parameter of antioxidant defense system, was significantly lower in patients on dialysis therapy than control group and in patients on HD than CAPD (p < 0.001 and p = 0.039, respectively). Statistically no significant difference was observed in levels of GSH-px between patients and control group and between patients on HD and CAPD.…”

Section: Discussionmentioning

confidence: 99%

Parameters of oxidative stress and echocardiographic indexes in patients on dialysis therapy

Kayabaşı

Şit²,

Atay

et al. 2010

Renal Failure

View full text Add to dashboard Cite

Aim: Quantity of oxidative stress (OS) is enhanced in every stage of chronic renal failure (CRF). OS and its effects on echocardiographic indexes in patients on hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) were evaluated. Materials and methods: Thirty-nine patients on CAPD, 32 patients on HD, and 30 healthy individuals with similar demographic features were included. Patients with diabetes mellitus and chronic inflammatory diseases were excluded. Blood samples were collected to examine hematological and biochemical parameters and levels of malonyldialdehyde (MDA), glutathione peroxidase (GSH-px), and superoxide dismutase (SOD) after a 12-hour fasting period in the middle of dialysis week. OS parameters were compared with ejection fraction (EF), interventricular septum diameter (IVSd), left ventricular posterior wall diameter (LVPWd), and left atrium diameter (LAd) determined in M-mod echocardiographic examination. Results: No significant difference was observed between MDA and GSH-px levels of patients and control group; however, SOD levels of patients group were significantly lower (p < 0.0001). SOD levels of patients on HD were lower than that of patients on CAPD (p = 0.039). No correlation was determined between antioxidants and cardiac indexes. Conclusion: SOD levels decreased significantly especially in patients on HD, and it was observed that lower levels of SOD would lead to OS in patients on HD and CAPD when compared to healthy individuals; MDA levels were independently influenced from EF.

show abstract

Myeloperoxidase serves as a marker of oxidative stress during single haemodialysis session using two different biocompatible dialysis membranes

Abstract: The biocompatibility of the dialyser affects oxidative stress production during a single dialysis session. The measurement of MPO may serve as a reliable marker of the degree of oxidative stress induced using dialysis membranes of different biocompatibilities.

Cited by 78 publications

References 16 publications

Assessment of Myeloperoxidase and Oxidative α1-Antitrypsin in Patients on Hemodialysis

Assessment of Myeloperoxidase and Oxidative α1-Antitrypsin in Patients on Hemodialysis

Effect of Hemodialysis on Plasma Myeloperoxidase Activity in End Stage Renal Disease Patients

Parameters of oxidative stress and echocardiographic indexes in patients on dialysis therapy

Contact Info

Product

Resources

About