Myelopathy in Marfan's syndrome

Pelvic pain from a giant presacral Tarlov cyst successfully obliterated using aneurysm clips in a patient with Marfan syndrome

“…24 Many of the Marfan syndrome pathologies related to the spinal meninges, such as dural ectasia, arachnoid cysts, and meningeal cysts, often do not produce any symptoms; however, radicular, myelopathic, and urinary symptoms from such pathologies have been reported in patients with this syndrome. 1,5,14,17,21,23 In addition, spontaneous spinal CSF leaks are much more commonly observed in patients with Marfan syndrome.…”

Pelvic pain from a giant presacral Tarlov cyst successfully obliterated using aneurysm clips in a patient with Marfan syndrome

“…24 Many of the Marfan syndrome pathologies related to the spinal meninges, such as dural ectasia, arachnoid cysts, and meningeal cysts, often do not produce any symptoms; however, radicular, myelopathic, and urinary symptoms from such pathologies have been reported in patients with this syndrome. 1,5,14,17,21,23 In addition, spontaneous spinal CSF leaks are much more commonly observed in patients with Marfan syndrome.…”

Targeted next‐generation sequencing reveals the genetic mechanism of Chinese Marfan syndrome cohort with ocular manifestation

“…MFS is characterized by multiple organ system abnormalities, including skeletal, ophthalmologic, and cardiovascular systems (Bitterman & Sponseller, 2017 ; Pyeritz & McKusick, 1979 ). Symptoms of MFS include increased height, generalized ligamentous and joint laxity, scoliosis, anterior chest deformity, dislocation or subluxation of crystals, myopia, glaucoma, dural ectasia, tooth deformity, widening or atrophic skin texture, aorta idiopathic dilation, cerebrovascular malformation, and pulmonary blebs (Brown et al., 1975 ; Newman & Tilley, 1979 ; Pyeritz & McKusick, 1979 ; Sponseller et al., 1995 ; Weir, 1973 ; Westling et al., 1998 ). It is suggested that the biochemical basis of MFS is the abnormality of connective tissue proteins or ground substances, including collagen primary structure abnormalities and hyaluronic acid synthesis (Appel et al., 1979 ; Byers et al., 1981 ; Pyeritz & McKusick, 1981 ).…”

Pelvic pain from a giant presacral Tarlov cyst successfully obliterated using aneurysm clips in a patient with Marfan syndrome

“…24 Many of the Marfan syndrome pathologies related to the spinal meninges, such as dural ectasia, arachnoid cysts, and meningeal cysts, often do not produce any symptoms; however, radicular, myelopathic, and urinary symptoms from such pathologies have been reported in patients with this syndrome. 1,5,14,17,21,23 In addition, spontaneous spinal CSF leaks are much more commonly observed in patients with Marfan syndrome.…”

Targeted next‐generation sequencing reveals the genetic mechanism of Chinese Marfan syndrome cohort with ocular manifestation

“…MFS is characterized by multiple organ system abnormalities, including skeletal, ophthalmologic, and cardiovascular systems (Bitterman & Sponseller, 2017 ; Pyeritz & McKusick, 1979 ). Symptoms of MFS include increased height, generalized ligamentous and joint laxity, scoliosis, anterior chest deformity, dislocation or subluxation of crystals, myopia, glaucoma, dural ectasia, tooth deformity, widening or atrophic skin texture, aorta idiopathic dilation, cerebrovascular malformation, and pulmonary blebs (Brown et al., 1975 ; Newman & Tilley, 1979 ; Pyeritz & McKusick, 1979 ; Sponseller et al., 1995 ; Weir, 1973 ; Westling et al., 1998 ). It is suggested that the biochemical basis of MFS is the abnormality of connective tissue proteins or ground substances, including collagen primary structure abnormalities and hyaluronic acid synthesis (Appel et al., 1979 ; Byers et al., 1981 ; Pyeritz & McKusick, 1981 ).…”

Pelvic pain from a giant presacral Tarlov cyst successfully obliterated using aneurysm clips in a patient with Marfan syndrome

“…24 Many of the Marfan syndrome pathologies related to the spinal meninges, such as dural ectasia, arachnoid cysts, and meningeal cysts, often do not produce any symptoms; however, radicular, myelopathic, and urinary symptoms from such pathologies have been reported in patients with this syndrome. 1,5,14,17,21,23 In addition, spontaneous spinal CSF leaks are much more commonly observed in patients with Marfan syndrome.…”

Targeted next‐generation sequencing reveals the genetic mechanism of Chinese Marfan syndrome cohort with ocular manifestation

“…MFS is characterized by multiple organ system abnormalities, including skeletal, ophthalmologic, and cardiovascular systems (Bitterman & Sponseller, 2017 ; Pyeritz & McKusick, 1979 ). Symptoms of MFS include increased height, generalized ligamentous and joint laxity, scoliosis, anterior chest deformity, dislocation or subluxation of crystals, myopia, glaucoma, dural ectasia, tooth deformity, widening or atrophic skin texture, aorta idiopathic dilation, cerebrovascular malformation, and pulmonary blebs (Brown et al., 1975 ; Newman & Tilley, 1979 ; Pyeritz & McKusick, 1979 ; Sponseller et al., 1995 ; Weir, 1973 ; Westling et al., 1998 ). It is suggested that the biochemical basis of MFS is the abnormality of connective tissue proteins or ground substances, including collagen primary structure abnormalities and hyaluronic acid synthesis (Appel et al., 1979 ; Byers et al., 1981 ; Pyeritz & McKusick, 1981 ).…”