David R. Fooksman, Michel C. Nussenzweig, Michael L. Dustin
Antibody secreting cell (ASC) expansion and survival are important processes in optimizing vaccines and controlling autoimmunity. The microenvironment of the medullary cords is positioned to control these key processes. Previously, we imaged and characterized ASC differentiation and migration by intravital microscopy in the lymph node (LN) by transferring and activating B cells expressing YFP only in the ASC compartment. In this study, we observed that YFP+ ASCs in the medullary cords migrated along myelomono…
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