Myelination of the rat retina by transplantation of oligodendrocytes into 4-day-old hosts

Huang, Paul P.; Alliquant, Bernadette; Carmel, Peter W.; Friedman, Eileen

doi:10.1016/0014-4886(91)90018-8

Cited by 25 publications

(10 citation statements)

References 30 publications

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“…The RNFL includes the retinal ganglion cell axons that comprise the optic nerve. As the axons in the RNFL are unmyelinated and have direct synapses into the lateral geniculate nucleus, it represents an appropriate district for the study of the CNS [13]. RNFL values are seen as potential structural markers for axonal loss and for CNS degeneration in different neurological and neurodevelopmental conditions.…”

Section: Introductionmentioning

confidence: 99%

Reduction in retinal nerve fiber layer thickness in tuberous sclerosis complex

et al. 2015

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Since a reduced RNFL thickness might be seen as an indicator of chronic axonal degeneration or lack of appropriate neuronal development, our results support the presence of axonal alterations in TSC and also that white matter disorganization could be much more diffuse than originally thought. Since axonal alterations directly derive from mammalian target of rapamycin (mTOR) overactivation, which occurs early during fetus development, the RNFL thinning we observed could represent one of the facets of such early neurodevelopmental abnormalities.

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Section: Introductionmentioning

confidence: 99%

Reduction in retinal nerve fiber layer thickness in tuberous sclerosis complex

et al. 2015

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“…Using this approach, it has recently been demonstrated that galactocerebroside (Ga1C)-and myelin basic protein (MBP)-positive oligodendrocytes transplanted into the retina of young postnatal rats survive and express MBP (Huang et al, 1991). We have extended this study and have analyzed: 1) whether transplanted oligodendrocyte progenitor cells differentiate into oligodendrocytes inside the retina; 2) whether transplanted cells are able to form morphologically normal myelin sheaths; and 3) whether the intraretinal segments of RGC axons become surrounded by a myelin sheath.…”

Section: Introductionmentioning

confidence: 99%

Transplantation of oligodendrocyte progenitor cells into the rat retina: Extensive myelination of retinal ganglion cell axons

Laeng

Molthagen

et al. 1996

Glia

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“…Unfortunately this prediction cannot be tested by using the X-EB model for which the lesion environment is devoid of astrocytes as well as oligodendrocytes. Thus, resolving this critical issue requires the use of alternative models such myelin mutants (Duncan et al, 1992) or the retina (Blakemore et al, 1986;Huang et al, 1991). The results of these studies are needed before it will be possible to accurately establish the potential value of OECs for transplant-mediated repair of demyelinating lesions of the CNS.…”

Section: Interactions With Astrocytes and Potential Clinical Applicatmentioning

confidence: 98%

Remyelination by transplanted olfactory ensheathing cells

Franklin

2003

The Anatomical Record Part B

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The olfactory ensheathing cells (OECs) of the peripheral olfactory system associate with the axons of the first cranial nerve. These axons are not myelinated by OECs because of their very small diameter. However, when OECs are transplanted into areas where they encounter larger-diameter axons, such as in a model of primary demyelination, these cells assume a myelinating phenotype. Myelinating OECs very closely resemble myelinating Schwann cells by all criteria currently examined, including morphology, ultrastructure, biochemistry, and transcriptional regulation. Indeed, it is currently impossible to reliably distinguish myelinating OECs and myelinating Schwann cells that have been transplanted into experimental models of CNS demyelination. This article describes recent studies on the myelinating properties of transplanted OECs, focusing on their intrinsic myelinating potential and how this can be augmented by the presence of meningeal cells. The relative merits of OECs compared with Schwann cells when transplanted into astrocyte-containing lesions in the CNS are discussed together with their potential role in transplanted-mediated repair of demyelinating disease such as multiple sclerosis.

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Myelination of the rat retina by transplantation of oligodendrocytes into 4-day-old hosts

Cited by 25 publications

References 30 publications

Reduction in retinal nerve fiber layer thickness in tuberous sclerosis complex

Reduction in retinal nerve fiber layer thickness in tuberous sclerosis complex

Transplantation of oligodendrocyte progenitor cells into the rat retina: Extensive myelination of retinal ganglion cell axons

Remyelination by transplanted olfactory ensheathing cells

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