Myelin Regeneration in Multiple Sclerosis: Targeting Endogenous Stem Cells

Huang, Jeffrey K.; Fancy, Stephen P.J.; Zhao, Chao; Rowitch, David H.; ffrench‐Constant, Charles; Franklin, Robin J.M.

doi:10.1007/s13311-011-0065-x

Cited by 50 publications

(32 citation statements)

References 88 publications

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“…In the present study, there was also an observed decrease in the amount of myelin after crushing (15 kgf), which is comparable with the density of nerve fibers diminished as reported by Oliveira et al [28]. Based on these facts, we suggest the use of this therapy as a possible treatment for diseases and injuries that lead to a loss of myelin, for example, multiple sclerosis, which is prevalent in young adults and affects 2.5 million people [29, 37]. The number of capillaries present in injured nerves was not altered by irradiation with LLLT after 10 and 21 days [35].…”

Section: Discussionsupporting

confidence: 85%

Application of a Low-Level Laser Therapy and the Purified Protein from Natural Latex (Hevea brasiliensis) in the Controlled Crush Injury of the Sciatic Nerve of Rats: A Morphological, Quantitative, and Ultrastructural Study

Días

Issa

Iyomasa

et al. 2013

BioMed Research International

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This study analyzed the effects of a low-level laser therapy (LLLT, 15 J/cm2, 780 nm wavelength) and the natural latex protein (P1, 0.1%) in sciatic nerve after crush injury (15 Kgf, axonotmesis) in rats. Sixty rats (male, 250 g) were allocated into the 6 groups (n = 10): CG—control group; EG—nerve exposed; IG—injured nerve without treatment; LG—crushed nerve treated with LLLT; PG—injured nerve treated with P1; and LPG—injured nerve treated with LLLT and P1. After 4 or 8 weeks, the nerve samples were processed for morphological, histological quantification and ultrastructural analysis. After 4 weeks, the myelin density and morphological characteristics improved in groups LG, PG, and LPG compared to IG. After 8 weeks, PG, and LPG were similar to CG and the capillary density was higher in the LG, PG, and LPG. In the ultrastructural analysis the PG and LPG had characteristics that were similar to the CG. The application of LLLT and/or P1 improved the recovery from the nerve crush injury, and in the long term, the P1 protein was the better treatment used, since only the application of LLLT has not reached the same results, and these treatments applied together did not potentiate the recovery.

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Section: Discussionsupporting

confidence: 85%

Application of a Low-Level Laser Therapy and the Purified Protein from Natural Latex (Hevea brasiliensis) in the Controlled Crush Injury of the Sciatic Nerve of Rats: A Morphological, Quantitative, and Ultrastructural Study

Días

Issa

Iyomasa

et al. 2013

BioMed Research International

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“…It is not completely understood why remyelination occurs so robustly in the periphery and so poorly in the CNS, though one hypothesis is that the environment after injury is hostile to OL terminal differentiation. In accordance with this hypothesis, a common feature of CNS lesions from patients with multiple sclerosis is an abundance of pre-myelinating OLs that fail to terminally differentiate (Huang et al, 2011). It is exciting to speculate on the use of both existing and to-be-developed zebrafish demyelination and remyelination models in genetic and small molecule screens, which could prove to be very important tools for elucidating molecular mechanisms that can promote or inhibit regeneration in the CNS of mammals (Buckley et al, 2008).…”

Section: Oligodendrocyte Development and Myelinationmentioning

confidence: 89%

The scales and tales of myelination: using zebrafish and mouse to study myelinating glia

Ackerman

Monk

2016

Brain Research

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Myelin, the lipid-rich sheath that insulates axons to facilitate rapid conduction of action potentials, is an evolutionary innovation of the jawed-vertebrate lineage. Research efforts aimed at understanding the molecular mechanisms governing myelination have primarily focused on rodent models; however, with the advent of the zebrafish model system in the late twentieth century, the use of this genetically tractable, yet simpler vertebrate for studying myelination has steadily increased. In this review, we compare myelinating glial cell biology during development and regeneration in zebrafish and mouse and enumerate the advantages and disadvantages of using each model to study myelination.

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“…112,113 For reasons discussed above, emphasis has been placed on the targeting of pathways that regulate differen tiation of OPCs into remyelinating oligo dendrocytes. This focus does not suggest that approaches to enhance OPC recruitment through migration and proliferation are obsolete but, rather, reflects the most recent research activity.…”

Section: Targets To Promote Remyelinationmentioning

confidence: 99%

Neuroprotection and repair in multiple sclerosis

et al. 2012

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Multiple sclerosis (MS) is an inflammatory demyelinating disease that is considered by many people to have an autoimmune aetiology. In recent years, new data emerging from histopathology, imaging and other studies have expanded our understanding of the disease and may change the way in which it is treated. Conceptual shifts have included: first, an appreciation of the extent to which the neuron and its axon are affected in MS, and second, elucidation of how the neurobiology of axon-glial and, particularly, axon-myelin interaction may influence disease progression. In this article, we review advances in both areas, focusing on the molecular mechanisms underlying axonal loss in acute inflammation and in chronic demyelination, and discussing how the restoration of myelin sheaths via the regenerative process of remyelination might prevent axon degeneration. An understanding of these processes could lead to better strategies for the prevention and treatment of axonal loss, which will ultimately benefit patients with MS.

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Myelin Regeneration in Multiple Sclerosis: Targeting Endogenous Stem Cells

Cited by 50 publications

References 88 publications

Application of a Low-Level Laser Therapy and the Purified Protein from Natural Latex (Hevea brasiliensis) in the Controlled Crush Injury of the Sciatic Nerve of Rats: A Morphological, Quantitative, and Ultrastructural Study

Application of a Low-Level Laser Therapy and the Purified Protein from Natural Latex (Hevea brasiliensis) in the Controlled Crush Injury of the Sciatic Nerve of Rats: A Morphological, Quantitative, and Ultrastructural Study

The scales and tales of myelination: using zebrafish and mouse to study myelinating glia

Neuroprotection and repair in multiple sclerosis

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