Myelin Oligodendrocyte Glycoprotein (MOG) Antibody Disease in a 11 Year Old with COVID-19 Infection

Khan, Archana; Panwala, Hiren; Ramadoss, Divya; Khubchandani, Raju

doi:10.1007/s12098-020-03656-7

Cited by 25 publications

(29 citation statements)

References 4 publications

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“…To our best knowledge, there have been nine reported cases of SARS-CoV-2 associated MOG-ON ( Table 1 ). 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 Eight of nine were newly diagnosed MOG-ON. Only one report was a case with relapsing MOG-ON after COVID-19 infection.…”

Section: Discussionmentioning

confidence: 99%

Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis with COVID-19 infection: A case report and literature review

Assavapongpaiboon

Apinyawasisuk

Jariyakosol

2022

American Journal of Ophthalmology Case Reports

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Section: Discussionmentioning

confidence: 99%

Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis with COVID-19 infection: A case report and literature review

Assavapongpaiboon

Apinyawasisuk

Jariyakosol

2022

American Journal of Ophthalmology Case Reports

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“…In a review of 43 cases of inflammatory disease of the CNS following SARS-CoV-2 infection, only 2 were known to be positive for anti-MOG antibodies (3). Table summarizes the reported cases of MOG antibodyassociated diseases after SARS-CoV-2 infection, including this case (2,(16)(17)(18)(19). So far, six such cases (including this case) have been reported, five in adults and one in a child.…”

Section: Discussionmentioning

confidence: 92%

SARS-CoV-2-related Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease: A Case Report and Literature Review

et al. 2022

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We herein report a case of MOG antibody-associated disease after SARS-CoV-2 infection. A 24-year-old woman developed unilateral optic neuritis 3 weeks after contracting COVID-19, followed by intracranial demyelinating lesions and myelitis. Since serum anti-MOG antibody was positive, we diagnosed MOG antibody-associated disease. Immunotherapy with steroids resulted in the rapid improvement of neurological symptoms. This is a suggestive case, as there are no reports of MOG antibody-associated disease with multiple neurological lesions occurring after COVID-19. The response to immunotherapy was favorable. This case suggests that it is important to measure anti-MOG antibodies in patients who develop inflammatory neurological disease after COVID-19.

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“…Zhou et al reported the first case of a 26-year-old who presented with dry cough and acute vision loss, to be ultimately diagnosed with COVID-19-associated, MOG-positive optic neuritis [ 26 ]. The first pediatric patient was recently published by Khat et al of an 11-year-old male with bilateral optic neuritis and CSF MOG positivity [ 27 ]. Rarely, COVID-19 infection can also serve as a trigger for anti-MOG disease relapse [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Para and Post-COVID-19 CNS Acute Demyelinating Disorders in Children: A Case Series on Expanding the Spectrum of Clinical and Radiological Characteristics

Khair¹,

Nikam²,

Husain³

et al. 2022

Cureus

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Viral infections can serve as a trigger for variable autoimmune, antibody-mediated demyelinating disorders. There is accumulating evidence that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, causing coronavirus disease 2019 (COVID-19) infection and responsible for the current worldwide pandemic, can lead to a cascade of immune-mediated brain and spinal cord demyelinating injuries. However, such observation in the pediatric age group was only reported in very few patients. Thus, the heterogeneous spectrum of this phenomenon in children is still unfolding. We are reporting a case series of five pediatric patients with a variety of acute central nervous system (CNS) demyelinating disorders in the context of acute or recent COVID-19 infection. A 16-year-old female with anti-myelin oligodendrocyte glycoprotein (MOG) disorder, an eight-year-old male with acute disseminated encephalomyelitis (ADEM), a 13-year-old female with neuromyelitis optica spectrum disorder (NMOSD), and two 14 and 13-year-old females with new-onset multiple sclerosis (MS) are reported, all of whom presented acutely following COVID-19 infection. We propose that para and post-infectious CNS demyelinating disorders can potentially follow acute COVID-19 infection in children. Considering SARS-CoV-2 testing as a part of diagnostic workup is possibly useful. Awareness of the presence of this phenomenon can help in the recognition and management of those patients.

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Myelin Oligodendrocyte Glycoprotein (MOG) Antibody Disease in a 11 Year Old with COVID-19 Infection

Cited by 25 publications

References 4 publications

Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis with COVID-19 infection: A case report and literature review

Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis with COVID-19 infection: A case report and literature review

SARS-CoV-2-related Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease: A Case Report and Literature Review

Para and Post-COVID-19 CNS Acute Demyelinating Disorders in Children: A Case Series on Expanding the Spectrum of Clinical and Radiological Characteristics

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