MyD88 Associated ROS Generation Is Crucial for Lactobacillus Induced IL-12 Production in Macrophage

Ichikawa, Shintaro; Miyake, Mika; Fujii, Ryota; Konishi, Yutaka

doi:10.1371/journal.pone.0035880

Cited by 28 publications

(24 citation statements)

References 52 publications

(52 reference statements)

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“…Downstream of the TLR signaling, the MyD88 adapter molecule is known to be crucial for the secretion of proinflammatory cytokines, such as IL-12 and IL-18 (29,30). MyD88 is involved in the downstream signaling of TLR4 and TLR9.…”

Section: Discussionmentioning

confidence: 99%

Low doses of ionizing radiation induce immune-stimulatory responses in isolated human primary monocytes

El‐Saghire

Michaux

Thierens

et al. 2013

International Journal of Molecular Medicine

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Abstract. The health effects arising from exposure to low doses of ionizing radiation are of particular concern, mainly due to the increased application of diagnostic and therapeutic X-ray modalities. The mechanisms behind the cell and tissue responses to low doses remain to be elucidated. Accumulating evidence suggests that low doses of ionizing radiation induce activation of the immune response; however, the processes involved have yet to be adequately investigated. Monocytes are key players in the induction of an immune response. Within the context of this study, we investigated the activation of toll-like receptors (TLRs), mitogen-activated protein kinases (MAPKs) and NF-κB signaling in isolated human primary monocytes in response to low doses (0.05 and 0

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Section: Discussionmentioning

confidence: 99%

Low doses of ionizing radiation induce immune-stimulatory responses in isolated human primary monocytes

El‐Saghire

Michaux

Thierens

et al. 2013

International Journal of Molecular Medicine

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“…Recently it has been noted that the activity of LAB stimulating the immune system is important (14,15,(20)(21)(22)(23). Yogurt is an example of fermented food with LAB.…”

Section: Screening Lab Activating Innate Immunity As a Yogurt Startermentioning

confidence: 99%

Lactic acid bacteria activating innate immunity improve survival in bacterial infection model of silkworm

Nishida¹,

Ono

Sekimizu

2016

DD&T

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“…IFN-␥ signaling has been shown to modulate NO and ROS production (21)(22)(23)(24). These two phagosomal enzymes are indicators of the innate inflammatory response to microbial infection.…”

Section: Myd88mentioning

confidence: 99%

“…Both MyD88 and Card9 are required for differentiation and development of Th1 and Th17 immunity in Coccidioides-infected lungs (18,19). MyD88-and Card9-mediated signal pathways also facilitate microbe-induced production of reactive oxygen species (ROS) and nitric oxide (NO) (20)(21)(22)(23). However, in the case of pulmonary disease, we and others have shown that inducible NO synthase (iNOS) and NADPH oxidase 2 (NOX2), two enzymes required for ROS and NO production, have limited influence on the control of Coccidioides infection of lung tissue (24)(25)(26).…”

mentioning

confidence: 99%

Card9- and MyD88-Mediated Gamma Interferon and Nitric Oxide Production Is Essential for Resistance to Subcutaneous Coccidioides posadasii Infection

2016

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Coccidioidomycosis is a potentially life-threatening respiratory disease which is endemic to the southwestern United States and arid regions of Central and South America. It is responsible for approximately 150,000 infections annually in the United States alone. Almost every human organ has been reported to harbor parasitic cells of Coccidioides spp. in collective cases of the disseminated form of this mycosis. Current understanding of the mechanisms of protective immunity against lung infection has been largely derived from murine models of pulmonary coccidioidomycosis. However, little is known about the nature of the host response to Coccidioides in extrapulmonary tissue. Primary subcutaneous coccidioidal infection is rare but has been reported to result in disseminated disease. Here, we show that activation of MyD88 and Card9 signal pathways are required for resistance to Coccidioides infection following subcutaneous challenge of C57BL/6 mice, which correlates with earlier findings of the protective response to pulmonary infection. MyD88 ؊/؊ and Card9 ؊/؊ mice recruited reduced numbers of T cells, B cells, and neutrophils to the Coccidioides-infected hypodermis compared to wild-type mice; however, neutrophils were dispensable for resistance to skin infection. Further studies have shown that gamma interferon (IFN-␥) production and activation of Th1 cells characterize resistance to subcutaneous infection. Furthermore, activation of a phagosomal enzyme, inducible nitric oxide synthase, which is necessary for NO production, is a requisite for fungal clearance in the hypodermis. Collectively, our data demonstrate that MyD88-and Card9-mediated IFN-␥ and nitric oxide production is essential for protection against subcutaneous Coccidioides infection.T wo species of Coccidioides, C. immitis and C. posadasii, are soilborne molds and the etiologic agents of coccidioidomycosis, a potentially life-threatening human respiratory disease that is also known as San Joaquin Valley fever. This pulmonary mycosis is endemic to the southwestern United States and certain arid regions of Mexico, as well as Central and South America (1). Recent evidence has revealed that C. posadasii occurs in Washington State, well north of the previously documented boundary of regions of endemicity for coccidioidal infections in the United States (2). Coccidioides is a diphasic pathogen, characterized by a saprobic phase that produces dry, air-dispersed, infectious spores from vegetative mycelia and a parasitic cycle which is unique among the medically important fungi (3). Inhaled spores grow isotropically in the lungs of the mammalian host to form the first generation of parasitic cells (spherule initials). The spherule initials continue to enlarge and differentiate into multinucleate spherules (Ͼ80 m in diameter). The cytoplasm of these coenocytes undergoes a process of segmentation by invagination of the inner spherule wall layer, followed by the formation of a multitude of endospores, each 2 to 10 m in diameter. Endospores also undergo isotropic...

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MyD88 Associated ROS Generation Is Crucial for Lactobacillus Induced IL-12 Production in Macrophage

Cited by 28 publications

References 52 publications

Low doses of ionizing radiation induce immune-stimulatory responses in isolated human primary monocytes

Low doses of ionizing radiation induce immune-stimulatory responses in isolated human primary monocytes

Lactic acid bacteria activating innate immunity improve survival in bacterial infection model of silkworm

Card9- and MyD88-Mediated Gamma Interferon and Nitric Oxide Production Is Essential for Resistance to Subcutaneous Coccidioides posadasii Infection

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