Mycosis fungoides with a widespread follicular eruption, comedones and cysts

Oliwiecki, S.; Ashworth, J.

doi:10.1111/j.1365-2133.1992.tb14828.x

Cited by 37 publications

(23 citation statements)

References 10 publications

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“…This presentation has already been identified in previous reports and has been considered highly specific for what was formerly called ''pilotropic MF.'' [7][8][9][10][11][12][13][14][15] In our experience, this acneiform clinical pattern is often associated with extensive areas of alopecia. 13 Other important observations in folliculotropic MF are the occasional presence of peculiar lesions such as excoriated nodules, xanthomatous changes, or pustules, which are very uncommonly found in conventional MF forms.…”

Section: Discussionmentioning

confidence: 99%

Folliculotropic mycosis fungoides: Clinicopathological features and outcome in a series of 20 cases

Muniesa

Estrach

Pujol³

et al. 2010

Journal of the American Academy of Dermatology

105

121

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Section: Discussionmentioning

confidence: 99%

Folliculotropic mycosis fungoides: Clinicopathological features and outcome in a series of 20 cases

Muniesa

Estrach

Pujol³

et al. 2010

Journal of the American Academy of Dermatology

105

121

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“…Follicular hyperkeratoses—comedones, cysts, and follicular plugs—have been reported in patients with mycosis fungoides; 4–14 however, the existence of these hyperkeratoses in parapsoriasis or early mycosis fungoides has not been reported so far.…”

Section: Discussionmentioning

confidence: 99%

Follicular cysts and hyperkeratoses in early mycosis fungoides

Kerkhof

1998

Int J Dermatology

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A 63‐year‐old woman had a 50‐year history of “dry skin.” At the age of 43, she presented for the first time at the Department of Dermatology with follicular hyperkeratotic papules on the upper legs, nates, abdomen, and upper arms ( Fig. 1). Histopathologic investigation revealed follicular hyperkeratoses with a mononuclear infiltrate, partly invading the hair follicles. The condition was diagnosed at first as keratosis pilaris and subsequently as pityriasis rubra pilaris. At the age of 52, the patient was treated with acitretin (35 mg per day as initial dose and 10–25 mg per day as maintenance dose). The condition improved considerably with this treatment, which was continued for 6 months. Following discontinuation of treatment, the condition relapsed after 6 months. 1 Follicular hyperkeratoses on the upper legs At the age of 58, the condition was aggravated with the formation of poikiloderma on the trunk, upper arms, and neck with reticular hyperpigmentations, scaling, and erythema, yellow cysts on the shoulders, back, and face ( Fig. 2), palmoplantar keratoderma, and scarring alopecia with loss of scalp, pubic, and axillary hair. The hair on the arms and trunk was also markedly reduced. Within 1 year, the condition was complicated by indurated erythematosquamous plaques on the trunk, upper arms, and upper legs. 2 Cysts of the neck and face Histopathologic investigation of repeated biopsies taken from the erythematosquamous plaques revealed a dense infiltrate of T lymphocytes (predominantly CD4 positive cells with some hyperchromatic indented nuclei) with epidermotropism of the hair follicles and interfollicular epidermis and some Pautrier microabscesses ( Fig. 3). The epidermis was partly orthokeratotic and parakeratotic. Histopathologic investigation of the epidermal cysts revealed a picture of epidermal cysts filled with horn material and invaded by some lymphocytes. The follicular hyperkeratoses consisted of orthokeratotic material with 3 Histopathologic appearance of an erythematosquamous plaque on the leg, showing a dense lymphocytic infiltrate, with epidermotropism of the interfollicular and follicular epidermis and some hyperchromatic indented nuclei (haematoxylin and eosin, original magnification ×100) lymphocytes invading the follicular wall. No mycosis fungoides cells and no depositions of mucin were observed. General investigation did not reveal pathologic lymph node, liver, or spleen enlargement. Routine blood investigations did not reveal abnormalities, in particular no Sezary cells, negative lues serology, and negative borrelia serology. Antinuclear factor and anti‐double‐stranded DNA were negative. X‐Ray examination of the thorax and computed tomography (CT) scan of the thorax and abdomen did not reveal abnormalities. At the age of 58, the patient had a heart infarction and, for this reason, was treated with metropolol, 100 mg per day, and acetyl salicylic acid, 80 mg per day. Following discontinuation of metropolol, the skin condition did not improve. Treatment with acitretin was reinst...

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“…However, pericystic MFinfiltrate is not a constant finding in the cases reported in the literature [ 12). Mucin deposits in hair follicles can be an additional finding of these cases [9,10,12,14],…”

Section: Discussionmentioning

confidence: 99%

“…The cystic lesions, dating only from 1 year, were observed not only within patches of MF but also on uninvolved skin. The occurrence of multiple eruptive cutaneous cysts in patients with MF is a rare event [8][9][10][11][12][13][14], Clinical data of the cases previously reported in the literature are summarized in table 2. Keratinous cysts can arise either on MF patches and plaques or on uninvolved skin.…”

Section: Discussionmentioning

confidence: 99%

Mycosis fungoides and Eruptive Epidermoid Cysts: A Unique Response of Follicular and Eccrine Structures

Aloi

Tomasini²,

Pippione³

1993

Dermatology

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A case of a patient who developed simultaneously mycosis fungoides (MF) and multiple, tiny eruptive cutaneous cysts on the face, neck and upper part of the trunk is reported. Histologically and immunohistochemically MF infiltrate was recognized not only in the upper part of the dermis and in the epidermis but also around and within the walls of cystic lesions. Furthermore, the eccrine structures were also involved by MF infiltrate. We emphasize that MF infiltrate can affect the follicular and eccrine structures inducing the formation of keratinous cysts. The clinical appearance of the facial lesions may be confused with Favre-Racouchot disease.

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Mycosis fungoides with a widespread follicular eruption, comedones and cysts

Abstract: Summary We describe a patient with a rare variant of mycosis fungoides (MF) presenting as a widespread follicular eruption with cysts and comedones.

Cited by 37 publications

References 10 publications

Folliculotropic mycosis fungoides: Clinicopathological features and outcome in a series of 20 cases

Folliculotropic mycosis fungoides: Clinicopathological features and outcome in a series of 20 cases

Follicular cysts and hyperkeratoses in early mycosis fungoides

Mycosis fungoides and Eruptive Epidermoid Cysts: A Unique Response of Follicular and Eccrine Structures

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