Mycosis fungoides associated with dystrophic xanthomatosis

McCadden, M. E.

doi:10.1001/archderm.123.1.91

Cited by 6 publications

(2 citation statements)

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“…Xanthomatous changes in the papillary dermis, similar to that in VX, have been described in association with several diseases, including mycosis fungoides,[17] epithelial nevi,[1819] and dystrophic epidermolysis bullosa. [2021] The changes may histologically resemble true VX and are considered to be a form of dystrophic xanthomatosis that possibly arises due to repeated epidermal or dermal damage, with accumulation of lipids within macrophages.…”

Section: Discussionmentioning

confidence: 99%

Verruciform xanthoma: Report of five cases

Joshi

Ovhal

2012

Indian J Dermatol

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We describe five cases of verruciform xanthoma (VX). The patients, all males, presented with single warty verrucous lesions of 0.5–2 cm size that had been diagnosed clinically as viral warts (four cases) and leukoplakia (one case). Two patients had the lesion in the oral cavity, two on the genital mucosa, and one on the scrotal skin. Histopathology was diagnostic, with verrucous and papillomatous epidermal hyperplasia with the silhouette of a viral wart but with numerous foamy histiocytes packed in the elongated dermal papillae. Columns of deep parakeratosis and neutrophils in the upper spinous layers, with a dermal plasma cell infiltrate were the other histopathologic findings. Excision of the lesions was curative, without recurrences, in the two patients who had lesions in the oral cavity; follow-up was not available in the cases with genital lesions. VX is an uncommon but distinctive clinicopathologic entity affecting the oral and genital mucosa that may be mistaken for benign, premalignant, and malignant conditions. VX can be diagnosed with certainty only on histopathologic examination.

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Section: Discussionmentioning

confidence: 99%

Verruciform xanthoma: Report of five cases

Joshi

Ovhal

2012

Indian J Dermatol

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“…In such instances, they usually corresponded to nodules undergoing degeneration or regression after treatment. Histologically, these lesions are characterized by a diffuse dermal infiltration with lipid-laden macrophages without an evident lymphomatous infiltrate [2, 4, 27, 28, 29, 30, 31, 32]. Only in rare circumstances has xanthomatosis been noted to develop in lesions of CD30+ cutaneous lymphoid proliferations [3, 27, 33].…”

Section: Discussionmentioning

confidence: 99%

Dystrophic Xanthomatosis in Primary CD30-Positive Cutaneous T-Cell Lymphoma

et al. 2005

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The development of xanthomatous changes in lesions of primary cutaneous T-cell lymphomas (CTCL) is a rare event. It is usually observed in regressing skin tumours or plaques spontaneously or after a specific treatment. The pathogenetic mechanisms implicated in these changes are poorly understood. We are reporting 2 cases of extensive dystrophic xanthomatous changes, developing in regressing lesions of primary cutaneous CD30-positive T-cell lymphoproliferative disorders. Previously reported cases of primary CTCL developing secondary (dystrophic) xanthomata are reviewed.

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