Mycosis fongoïde après transplantation cardiaque

Bodard, Q.; Litrowski, N.; Carré, Dominique; Midhat, M.; Chenal, Pierre; Bravard, P.

doi:10.1016/j.annder.2017.05.008

Cited by 3 publications

(8 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MF among SOTRs is rarely described, with approximately 34 cases reported since 1992 [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. An incidence rate of 1.903 patients with MF per 1,000 SOTRs was observed in the present study, which is [24,25].…”

Section: Discussionsupporting

confidence: 49%

“…Although this finding may only reflect the increased transplantation rate of other organs than the kidney with time [32], the nature of the transplanted organ and the different immunosuppression protocols can also have its contribution. The median interval between first transplantation and the diagnosis of MF according to the literature was 6 years [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21], compared to 8 years in the present study. In previous reports, all but 1 were adult patients [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21].…”

Section: Discussionmentioning

confidence: 56%

“…The median interval between first transplantation and the diagnosis of MF according to the literature was 6 years [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21], compared to 8 years in the present study. In previous reports, all but 1 were adult patients [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. In contrast, in the present study, 4/10 were younger than 18 years, which may also be explained by a referral bias, as pediatric posttransplant patients are under surveillance at specific centers in Israel with high awareness for MF.…”

Section: Discussionmentioning

confidence: 56%

“…The reported cases of MF/SS in SOTRs had heterogeneous characteristics and course of disease, and the approach toward alterations of the immunosuppression in the setup of lymphoma, given to prevent organ rejection, was not uniform [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. In the present study, the characteristics, management, and course of MF in SOTRs are presented, with a specific focus on the therapeutic approach for MF, and on the management of the immunosuppressive treatments given to these patients.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Mycosis Fungoides in Solid-Organ Transplant Recipients: A Multicenter Retrospective Cohort Study

Amitay-Laish,

Didkovsky,

Davidovici

et al. 2023

Dermatology

View full text Add to dashboard Cite

Background: Mycosis fungoides (MF) in solid-organ transplant recipients (SOTR) is rare, with limited data on disease characteristics. Objective: To study the characteristics of MF in SOTR with an emphasis on the immunosuppressive therapy. Methods: A retrospective cohort of patients diagnosed with MF, who were also SOTR, followed at 3 cutaneous lymphoma outpatient-clinics, between 1/2010-02/2022. Results: Ten patients were included, (7 male; median ages at transplantation and at-diagnosis of MF were, 33 and 48 years, respectively; 40% were diagnosed before the age of 18 years). Median time from transplantation to diagnosis of MF was 8 years, (range 0.5-22). Transplanted organs and immunosuppressive treatments included: liver, (n=5; 4 treated with tacrolimus, 1 with tacrolimus and prednisone), kidney (n=3), liver and kidney (n=1), and heart (n=1), all treated with mycophenolic acid, tacrolimus, and prednisone. Nine had early-stage MF, [IA-4, IB-5; 40% with early-folliculotropic MF], treated with skin-directed-therapies, in 2 combined with acitretin, achieving partial/complete response. One patient had advanced-stage MF (IIIA) with folliculotropic erythroderma, treated with-ultraviolet A and narrowband-ultraviolet B with acitretin, achieving partial response. Immunosuppression was modified in 3. At last follow-up, (median 4 years, range 1-8), no stage-progression was observed; 5 had no evidence of disease, 5 had active disease-(IA/IB-4, III-1). Conclusions: MF in SOTR is usually diagnosed at an early-stage, with over representation of folliculotropic MF, and of children. Immunosuppressive therapy alterations, not conducted in most patients, should be balanced against the risk of organ compromise/rejection. Disease-course was similar to MF in immunocompetent patients, during the limited time of follow-up.

show abstract

Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mycosis Fungoides in Solid-Organ Transplant Recipients: A Multicenter Retrospective Cohort Study

Amitay-Laish,

Didkovsky,

Davidovici

et al. 2023

Dermatology

View full text Add to dashboard Cite

show abstract

“…Kaposi sarcoma (associated with human herpes simplex virus 8) and cutaneous anaplastic large-cell lymphoma (ALCL) usually occur early after transplantation, while other tumors such as NMSC, Merkel cell carcinoma, malignant melanoma or adnexal tumors manifest later in time ( 7 , 38 , 39 ). Rarely, cutaneous T-cell lymphoma ( Mycosis fungoides ) and multiple atypical fibroxanthomas can occur ( 40 - 42 ). The incidence of most of these tumors, including NMSC, increases in time after transplantation, with patients having a 6.7% higher risk of developing NMSC at 10 years and 20.4% higher risk at 20 years after organ transplantation ( 43 ).…”

Section: Discussionmentioning

confidence: 99%