Mycobacterium kansasii infection with dermatologic manifestations

Abstract

A patient with cutaneous lesions as a manifestation of systemic infection with Mycobacterium kansasii is described. To our knowledge, this is the fourth reported case of a patient with dermatologic lesions secondary to M kansasii infection. A brief review of the classification and clinical presentations of atypical mycobacteria is given.

Disseminated Mycobacterium kansasii infection with cutaneous lesions in an immunocompetent patient

“…Eight cases of disseminated skin infection were identified among 1735 previous studies of M. kansasii disease reported from 1956 to February 2017 in the PubMed database (Fraser et al, 1975;Hirsh and Saffold, 1976;Tempero and Smith, 1981;Kramers et al, 1992;Mandal et al, 1992;Kotb et al, 2001;Nomura et al, 2009;Han et al, 2010). The case presented herein is the second case of disseminated M. kansasii disease involving the skin in a previously healthy patient, with the first case reported in 2001 (Kotb et al, 2001).…”

Mycobacteria other than Mycobacterium tuberculosis are not present in erythema induratum/nodular vasculitis: a case series and literature review of the clinical and histologic findings

“…Central hyperkeratosis with parakeratosis and epidermal necrosis with multinucleated keratinocytes and acantholytic cells may be seen. An intense mixed inflammatory infiltrate containing eosinophils may be present in the dermis 30 . The histologic picture may depend on the stage of infection and the immune status of the host with immunocompromised patients, showing neutrophilic inflammation with occasional abscess formation, whereas immunocompetent hosts show a granulomatous infiltrate with or without necrosis 24 .…”

Primary Cutaneous Mycobacterium kansasii Infection in a Child

“…Cutaneous infection by M. kansasii is rare. To our knowledge, 45 patients have been described, with ages ranging from 16 to 84 years (6–33). In 72% of those cases, an immunologic disorder resulting from chemotherapy, autoimmune disease, AIDS, renal or cardiac transplantation, or other predisposing factors (14) was identified.…”

“…Cutaneous M. kansasii infections are rare. The first case was described by Mayberry et al (6) in 1965, and an additional 44 cases have been reported since then (7–33). Furthermore, none of these patients with cutaneous M. kansasii infection were children.…”