Mycobacterium Chimaera Choroiditis

Kongwattananon, Wijak; Brod, Roy D.; Kodati, Shilpa

doi:10.1016/j.oret.2020.12.027

Cited by 3 publications

(1 citation statement)

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“…Similarly, to a TB infection, if other organs are infected, additional organ-specific symptoms can occur [ 5 , 13 , 16 , 17 ]. In particular, it has been shown that the infection has a very strong proclivity for the eyes [ 7 , 8 , 9 , 10 , 18 ]. If not promptly diagnosed and treated, M. chimaera infections often become life-threatening [ 5 , 7 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Differences between Mycobacterium chimaera and tuberculosis Using Ocular Multimodal Imaging: A Systematic Review

Zweifel

Foa

Wiest

et al. 2021

JCM

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Due to their non-specific diagnostic patterns of ocular infection, differential diagnosis between Mycobacterium (M.) chimaera and tuberculosis can be challenging. In both disorders, ocular manifestation can be the first sign of a systemic infection, and a delayed diagnosis might reduce the response to treatment leading to negative outcomes. Thus, it becomes imperative to distinguish chorioretinal lesions associated with M. chimaera, from lesions due to M. tuberculosis and other infectious disorders. To date, multimodal non-invasive imaging modalities that include ultra-wide field fundus photography, fluorescein and indocyanine green angiography, optical coherence tomography and optical coherence tomography angiography, facilitate in vivo examination of retinal and choroidal tissues, enabling early diagnosis, monitoring treatment response, and relapse detection. This approach is crucial to differentiate between active and inactive ocular disease, and guides clinicians in their decisional-tree during the patients’ follow-up. In this review, we summarized and compared the available literature on multimodal imaging data of M. chimaera infection and tuberculosis, emphasizing similarities and differences in imaging patterns between these two entities and highlighting the relevance of multimodal imaging in the management of the infections.

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Section: Introductionmentioning

confidence: 99%

Differences between Mycobacterium chimaera and tuberculosis Using Ocular Multimodal Imaging: A Systematic Review

Zweifel

Foa

Wiest

et al. 2021

JCM

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Recurrent Choroidal Neovascular Membrane as the Initial Presentation of Mycobacterium chimaera -Associated Serpiginoid Choroiditis

Babu,

Padmapriya,

Gowda

et al. 2024

Ocular Immunology and Inflammation

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Long-Term Clinical and Multimodal Imaging Findings in Patients with Disseminated Mycobacterium Chimaera Infection

Zweifel

Wiest

Toro

et al. 2021

JCM

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Background: To analyze long-term ophthalmic clinical and multimodal imaging findings of disseminated Mycobacterium (M.) chimaera infection after cardiothoracic surgery among the Swiss Cohort. Methods: Systemic and multimodal ophthalmic imaging and clinical findings including rate of recurrence were reviewed and correlated to a previously proposed classification system of choroidal lesions and classification of ocular disease. Main Outcomes Measures: long-term clinical and multimodal ocular imaging findings of M. chimaera. Results: Twelve patients suffering from systemic infection from M. chimaera were included. Mean age at the first ophthalmic examination was 59 years (range from 48 to 66 years). Mean duration of the follow-up was 22.63 ± 17.8 months. All patients presented with bilateral chorioretinal lesions at baseline; 5 patients had additional signs, including optic disc swelling (2), choroidal neovascularization (1), retinal neovascularization (1) and cilioretinal vascular occlusion (1). Four recurrence events after discontinuation or adjustment of the antibiotic treatment were observed. Progressive choroiditis was seen in 5 patients under treatment, 4 of them deceased. Conclusions: Expertise from ophthalmologists is not only relevant but also critical for the assessment of the adverse drug effect of antimycobacterial treatment along with monitoring therapeutic response and identifying recurrences.

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Mycobacterium Chimaera Choroiditis

Cited by 3 publications

References 0 publications

Differences between Mycobacterium chimaera and tuberculosis Using Ocular Multimodal Imaging: A Systematic Review

Differences between Mycobacterium chimaera and tuberculosis Using Ocular Multimodal Imaging: A Systematic Review

Recurrent Choroidal Neovascular Membrane as the Initial Presentation of Mycobacterium chimaera -Associated Serpiginoid Choroiditis

Long-Term Clinical and Multimodal Imaging Findings in Patients with Disseminated Mycobacterium Chimaera Infection

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