MYC amplifies mitotic perturbations elicited by LXY18 to enable synthetic lethality
Julia Kalashova,
Chenglu Yang,
Yan Long
et al.
Abstract:The MYC oncoprotein represents an intriguing target for cancer treatment, but its therapeutic potential has been hindered by the absence of specific pharmacological inhibitors. In this study, we demonstrate that the phenoxy quinoline compound LXY18 selectively targets and eliminates cells overexpressing MYC, leaving non-transformed cells unharmed. This synthetic lethality arises from an acute induction of multipolarity, resulting in a persistent arrest in early mitosis followed by cell death in mitosis or afte… Show more
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