MYB Transcription Factors as Regulators of Phenylpropanoid Metabolism in Plants

Liu, Jingying; Osbourn, Anne; Ma, Pengda

doi:10.1016/j.molp.2015.03.012

Cited by 735 publications

(589 citation statements)

References 175 publications

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“…Of them, the roles of R1 MYB, R2-MYB, R2R3-MYB TFs in regulation of the synthesis of different phenylpropanoid-derived compounds have been extensively studied in many plants such as Arabidopsis, maize, rice, soybean and other plants. 17 In the current analysis, the metabolic genes associated with the reporter metabolites were significantly enriched with putative cis-elements such as MYB-box-like, MYB-box related-like, GARE-like and pyrimidine-box-like associated with the different types of R1MYB, R2MYB and R2R3 MYB in response to both blue and red lights. The enrichment of these elements is supported by the upregulation of Os02g0685200 and Os02g0706400 in blue light, signifying their role in the regulation of the synthesis of different phenolic compounds.…”

Section: Transcriptional Regulation Of Phenolic Compounds Accumulationmentioning

confidence: 62%

Light-specific transcriptional regulation of the accumulation of carotenoids and phenolic compounds in rice leaves

Mohanty

Lim

Kim

et al. 2016

Plant Signaling & Behavior

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Section: Transcriptional Regulation Of Phenolic Compounds Accumulationmentioning

confidence: 62%

Light-specific transcriptional regulation of the accumulation of carotenoids and phenolic compounds in rice leaves

Mohanty

Lim

Kim

et al. 2016

Plant Signaling & Behavior

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“…It is currently established that R2R3-type MYB and basic helix-loop-helix (bHLH) TF families are the most important transcriptional regulators of flavonoid biosynthesis (Xu et al 2015;Liu et al 2015). The transcriptional regulation of anthocyanin and proanthocyanidin biosynthesis has been more extensively studied, and it has been shown that it is mainly exerted by the action of so-called MBW regulation complexes consisting of the R2R3-MYB and bHLH TFs in conjunction with the WD-repeat proteins (WDR).…”

Section: Regulation Of Flavonoid Biosynthesis In Plants: a Comparisonmentioning

confidence: 99%

Regulation of stilbene biosynthesis in plants

Dubrovina

Kiselev

2017

Planta

134

126

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Main conclusion This review analyzes the advances in understanding the natural signaling pathways and environmental factors regulating stilbene biosynthesis. We also discuss the studies reporting on stilbene content and repertoire in plants.Stilbenes, including the most-studied stilbene resveratrol, are a family of phenolic plant secondary metabolites that have been the subject of intensive research due to their valuable pharmaceutical effects and contribution to plant disease resistance. Understanding the natural mechanisms regulating stilbene biosynthesis in plants could be useful for both the development of new plant protection strategies and for commercial stilbene production. In this review, we focus on the environmental factors and cell signaling pathways regulating stilbene biosynthesis in plants and make a comparison with the regulation of flavonoid biosynthesis. This review also analyzes the recent data on stilbene biosynthetic genes and summarizes the available studies reporting on both stilbene content and stilbene composition in different plant families.

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“…Notably, some genes in the phenolic acid biosynthetic branch (Liu et al, 2015) were also differentially expressed in the Dy mutants ( Fig. 6; Supplemental Table S3A).…”

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confidence: 98%

Characterization of a New Pink-Fruited Tomato Mutant Results in the Identification of a Null Allele of the SlMYB12 Transcription Factor

et al. 2016

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The identification and characterization of new tomato (Solanum lycopersicum) mutants affected in fruit pigmentation and nutritional content can provide valuable insights into the underlying biology, as well as a source of new alleles for breeding programs. To date, all characterized pink-pigmented tomato fruit mutants appear to result from low SlMYB12 transcript levels in the fruit skin. Two new mutant lines displaying a pink fruit phenotype (pf1 and pf2) were characterized in this study. In the pf mutants, SlMYB12 transcripts accumulated to wild-type levels but exhibited the same truncation, which resulted in the absence of the essential MYB activation domain coding region. Allelism and complementation tests revealed that both pf mutants were allelic to the y locus and showed the same recessive null allele in homozygosis: Dy. A set of molecular and metabolic effects, reminiscent of those observed in the Arabidopsis (Arabidopsis thaliana) myb11 myb12 myb111 triple mutant, were found in the tomato Dy mutants. To our knowledge, these have not been described previously, and our data support the idea of their being null mutants, in contrast to previously described transcriptional hypomorphic pink fruit lines. We detected a reduction in the expression of several flavonol glycosides and some associated glycosyl transferases. Transcriptome analysis further revealed that the effects of the pf mutations extended beyond the flavonoid pathway into the interface between primary and secondary metabolism. Finally, screening for Myb-binding sites in the candidate gene promoter sequences revealed that 141 of the 152 co-down-regulated genes may be direct targets of SlMYB12 regulation.

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MYB Transcription Factors as Regulators of Phenylpropanoid Metabolism in Plants

Cited by 735 publications

References 175 publications

Light-specific transcriptional regulation of the accumulation of carotenoids and phenolic compounds in rice leaves

Light-specific transcriptional regulation of the accumulation of carotenoids and phenolic compounds in rice leaves

Regulation of stilbene biosynthesis in plants

Characterization of a New Pink-Fruited Tomato Mutant Results in the Identification of a Null Allele of the SlMYB12 Transcription Factor

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