Myasthenic Syndrome with Associated Neuropathy

Neurogenic muscle involvement in myasthenia gravis: A clinical and histopathological study

“…The generalized muscular atrophy observed in these patients, therefore, cannot be directly related to the myasthenia. Similar cases have been described by Steidl et al (1962) and Lowenberg-Scharenberg (1962), who did not, however, present detailed post mortem findings in the spinal cord and peripheral nerves. re (5) It is virtually certain that acetylcholine, besides transmitting the impulse, exerts a trophic influence on the muscle.…”

“…described a patient with bilateral lingual atrophy. Oppenheim (1901) mentioned in his monograph But in a number of subsequent publications the that he found muscular atrophy in a number of occurrence of muscular atrophy proved to be a his patients, along with greatly diminished controversial subject, and patients in this category were therefore described as suffering from: myasthenic syndrome with pseudomyopathy (Alajouanine, Lemaire, and Bourgignon, 1954); myasthenic syndrome with progressive muscular dystrophy (Striippler, 1955); myasthenic syndrome with associated neuropathy (Steidl, Oswald, and Kottke, 1962); myasthenic syndrome with polymyositis (Jesel, Stoebner, Zenglin, and Isch, 1969); ophthalmoplegia and myasthenic syndrome (Bonduelle, Bouygues, and Puech, 1954); myopathy with myasthenia gravis (Griffin, Nattrass, and Posk, 1956); myasthenia gravis with myopathic atrophy (Hosotte, 1951); descending dystrophy or myasthenia gravis (Hausmanova-Petrusewicz, Falkieviczowa, Jedrzejewska, Kaimieniecka, and Fidianska, 1965). Some publications on polymyositis (Christensen and Levison, 1950;Cbers, 1956, case 6) seem to refer to patients with myasthenia gravis.…”

Denervation of Muscle in Myasthenia Gravis

“…Groups of small muscle fibers have been observed in patients with myasthenia gravis by Russell,5 Steidl et al,6 Lowenberg-Scharenberg,7 and Fenichel and Shy.1 One patient in the series of Fenichel and Shy had large groups of small fibers. In addi-tion to the similarity of their muscle bi¬ opsies, there was a clinical resemblance between our patient and that patient, who was a 37-year-old woman with symptoms of myasthenia gravis for 27 years.…”

Neurogenic muscle atrophy in myasthenia gravis

“…In previous reports of neurogenic atrophy in myasthenic muscle (Steidl, Oswald, and Kottke, 1962;Fenichel and Shy, 1963;Brody and Engel, 1964;Fenichel, 1966;Hughes and Brownell, 1968) the affected muscle fibres have shown either a diffusely scattered or a 'grouped' pattern of distribution. Both patterns were seen in our case 2.…”