Myasthenia Gravis

Cogan's Lid Twitch Sign in a Child with Congenital Myasthenia

“…Cogan's lid twitch sign was first described by an American Ophthalmologist, David Glendenning Cogan in 1965. 1 This sign is seen in myasthenia gravis with 50 to 99% sensitivity and 75 to 100% specificity 2 and also reported in dorsal midbrain lesions and Miller Fisher syndrome. 3,4 The sign is elicited by asking the patient to look downward for 10 to 15 seconds and to return to the primary gaze, and the sign is present when brief twitches of the affected eyelid are seen.…”

Cogan's Lid Twitch Sign in a Child with Congenital Myasthenia

“…Cogan's lid twitch sign was first described by an American Ophthalmologist, David Glendenning Cogan in 1965. 1 This sign is seen in myasthenia gravis with 50 to 99% sensitivity and 75 to 100% specificity 2 and also reported in dorsal midbrain lesions and Miller Fisher syndrome. 3,4 The sign is elicited by asking the patient to look downward for 10 to 15 seconds and to return to the primary gaze, and the sign is present when brief twitches of the affected eyelid are seen.…”

Validity of Forced Eyelid Closure Test: A Novel Clinical Screening Test for Ocular Myasthenia Gravis

“…In 1965, Cogan (8) first introduced CLT as a characteristic eyelid sign of myasthenia gravis and proposed fatigability followed by increased gain and then a rapid recovery of extraocular muscles including LPS as an explanation for this phenomenon. When the patient’s eyes return to primary position after the period of LPS relaxation on downgaze, the eyelid shoots upward excessively for a brief moment exposing the upper limbus due to rapid recovery of Ach levels in the context of compensatory gain before returning to resting position, and appears as a twitch.…”

Myogenic Palsies

“…(2) Cogan's lid twitch sign (Cogan 1965), which can be demonstrated by first asking the patient to look down for 15 seconds and then to make a fast refixation movement to the primary position. Lid movement follows eye movement on down-gaze, but when the eye returns to the primary position the lid momentarily moves above its previous level (the lid twitch) before returning to its ptotic position.…”

Cogan's Lid Twitch Sign in a Child with Congenital Myasthenia

“…Cogan's lid twitch sign was first described by an American Ophthalmologist, David Glendenning Cogan in 1965. 1 This sign is seen in myasthenia gravis with 50 to 99% sensitivity and 75 to 100% specificity 2 and also reported in dorsal midbrain lesions and Miller Fisher syndrome. 3,4 The sign is elicited by asking the patient to look downward for 10 to 15 seconds and to return to the primary gaze, and the sign is present when brief twitches of the affected eyelid are seen.…”

Validity of Forced Eyelid Closure Test: A Novel Clinical Screening Test for Ocular Myasthenia Gravis

“…In 1965, Cogan (8) first introduced CLT as a characteristic eyelid sign of myasthenia gravis and proposed fatigability followed by increased gain and then a rapid recovery of extraocular muscles including LPS as an explanation for this phenomenon. When the patient’s eyes return to primary position after the period of LPS relaxation on downgaze, the eyelid shoots upward excessively for a brief moment exposing the upper limbus due to rapid recovery of Ach levels in the context of compensatory gain before returning to resting position, and appears as a twitch.…”

Myogenic Palsies

“…(2) Cogan's lid twitch sign (Cogan 1965), which can be demonstrated by first asking the patient to look down for 15 seconds and then to make a fast refixation movement to the primary position. Lid movement follows eye movement on down-gaze, but when the eye returns to the primary position the lid momentarily moves above its previous level (the lid twitch) before returning to its ptotic position.…”

Cogan's Lid Twitch Sign in a Child with Congenital Myasthenia

“…Cogan's lid twitch sign was first described by an American Ophthalmologist, David Glendenning Cogan in 1965. 1 This sign is seen in myasthenia gravis with 50 to 99% sensitivity and 75 to 100% specificity 2 and also reported in dorsal midbrain lesions and Miller Fisher syndrome. 3,4 The sign is elicited by asking the patient to look downward for 10 to 15 seconds and to return to the primary gaze, and the sign is present when brief twitches of the affected eyelid are seen.…”

Validity of Forced Eyelid Closure Test: A Novel Clinical Screening Test for Ocular Myasthenia Gravis

“…In 1965, Cogan (8) first introduced CLT as a characteristic eyelid sign of myasthenia gravis and proposed fatigability followed by increased gain and then a rapid recovery of extraocular muscles including LPS as an explanation for this phenomenon. When the patient’s eyes return to primary position after the period of LPS relaxation on downgaze, the eyelid shoots upward excessively for a brief moment exposing the upper limbus due to rapid recovery of Ach levels in the context of compensatory gain before returning to resting position, and appears as a twitch.…”

Myogenic Palsies

“…(2) Cogan's lid twitch sign (Cogan 1965), which can be demonstrated by first asking the patient to look down for 15 seconds and then to make a fast refixation movement to the primary position. Lid movement follows eye movement on down-gaze, but when the eye returns to the primary position the lid momentarily moves above its previous level (the lid twitch) before returning to its ptotic position.…”